The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Role of Inflammation in Atrial Fibrillation Pathophysiology and Management
Open accessAbstract
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia, but the methods available for treating AF and its complications (of which the most important is thrombogenesis), as well as for assessing AF risk and underlying pathophysiology, are largely limited. Emerging evidence suggests a significant role of inflammation in the pathogenesis of AF. That evidence includes elevated serum levels of inflammatory biomarkers in AF subjects, the expression of inflammatory markers in cardiac tissues of AF patients and animal models of AF, and beneficial effects of anti-inflammatory drugs in experimental AF paradigms. Inflammation is suggested to be linked to various pathological processes, such as oxidative stress, apoptosis, and fibrosis, that promote AF substrate formation. Inflammation has also been associated with endothelial dysfunction, platelet activation, and coagulation cascade activation, leading to thrombogenesis. Thus, inflammation may contribute to both the occurrence/maintenance of AF and its thromboembolic complications. Here, we review the evidence for a role of inflammation and inflammatory biomarkers in the risk management and treatment of AF. We also summarize the current knowledge of inflammation-dependent cellular and molecular mechanisms in AF pathophysiology and their potential as therapeutic targets.
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Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
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Self-citationAtrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation
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Self-citationAndrade, J., Khairy, P., Dobrev, D., & Nattel, S. (2014) · Circulation Research · doi:10.1161/circresaha.114.303211 · Cited by 1,187
Self-citationAtrial Remodeling and Atrial Fibrillation: Mechanisms and Implications
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Self-citationMechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited
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Inflammation in Atrial Fibrillation
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C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor
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Atrial Remodeling and Atrial Fibrillation
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Self-citation
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Dobrev, D., Heijman, J., Hiram, R., Li, N., & Nattel, S. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00759-w · Cited by 268
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Neefs, J., van den Berg, N. W. E., Limpens, J., Berger, W. R., Boekholdt, S. M., Sanders, P., & de Groot, J. R. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.12.029 · Cited by 111
Svedberg, N., Sundström, J., James, S., Hållmarker, U., Hambraeus, K., & Andersen, K. (2019) · Circulation · doi:10.1161/circulationaha.118.039461 · Cited by 92
Metadata
- Authors
- Harada, M., Van Wagoner, D. R., & Nattel, S.
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2015
- Volume
- 79
- Issue
- 3
- Pages
- 495-502
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W2091365349
- Cited by
- 473
- References
- 80
- FWCI
- 20.97
- Type
- journal article
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
