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Inflammation in Atrial Fibrillation

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Guo, Yutao, Lip, Gregory Y.H., Apostolakis, Stavros·2012·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2012.04.063
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Abstract

Atrial fibrillation (AF) is associated with increased risk for stroke and systemic embolism. There is plausible evidence linking inflammation to the initiation and perpetuation of AF and AF-related thrombosis. Various inflammatory markers (C-reactive protein, tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-8) have been associated with AF. Proposed mechanisms linking inflammation and the prothrombotic AF state include endothelial activation/damage, production of tissue factor from monocytes, increased platelet activation, and increased expression of fibrinogen. The present review aims to provide an update on the association of inflammation and AF, including the impact of inflammatory markers on clinical presentation and outcome of AF patients.

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Metadata

Authors
Guo, Y., Lip, G. Y. H., & Apostolakis, S.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2012-12
Volume
60
Issue
22
Pages
2263-2270
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2012.04.063
OpenAlex
W1971347950
Cited by
863
References
1
FWCI
25.32
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: Inflammation in Atrial Fibrillation. https://app.cochat.ai/papers/10.1016/j.jacc.2012.04.063
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Guo, Y., Lip, G. Y. H., & Apostolakis, S. (2012). Inflammation in Atrial Fibrillation. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2012.04.063

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