Nocturnal Hypoxemia, But Not Sleep Apnea, Is Associated With a Poor Prognosis in Patients With Pulmonary Arterial Hypertension
Open accessAbstract
BACKGROUND: Sleep apnea (SA) can cause repeated nocturnal arterial oxygen desaturation and result in acute increase in pulmonary arterial pressure (PAP). The presence of SA is associated with a poor prognosis in patients with chronic left-sided heart failure, but little is known for patients with pulmonary arterial hypertension (PAH). METHODS AND RESULTS: =14.7, P<0.001) and that was the only independent variable related to death in multivariate Cox proportional hazards analysis. CONCLUSIONS: SA in patients with PAH was not associated with worse prognosis, unlike left ventricular heart failure, but nocturnal hypoxemia was related to poor prognosis.
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Duration and severity of nocturnal oxygen desaturation is an important risk factor for development of pulmonary arterial hypertension.
“suggesting that duration and severity of nocturnal oxygen desaturation, well known to occur in OSA patients, is an important risk factor for development of PAH.”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [776]
The Abstract (page unavailable) says sleep apnea can cause repeated nocturnal desaturation and that hypoxia can increase pulmonary arterial pressure and promote vascular remodeling. But the study enrolled people who already had PAH; its Prognosis and Outcome sections link nocturnal hypoxemia to poorer survival, not the development of PAH. It does not establish duration or severity of desaturation as a risk factor for developing PAH. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIn those patients, mortality was significantly higher in those with nocturnal hypoxemia, defined as average SpO2 below 90%.
“however, mortality was significantly higher in patients with nocturnal hypoxemia, defined as an average SpO2 < 90%”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [776]
In patients with WHO group I pulmonary arterial hypertension, mortality did not differ significantly between those with and without obstructive sleep apnea.
“A study of WHO group I PAH patients showed there was no significant difference in mortality in patients with and without OSA”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [776]
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- Authors
- Nagaoka, M., Goda, A., Takeuchi, K., Kikuchi, H., Finger, M., Inami, T., Soejima, K., & Satoh, T.
- Affiliations
- Kyorin University (JP)
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2018-11-24
- Volume
- 82
- Issue
- 12
- Pages
- 3076-3081
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W2896471252
- Cited by
- 45
- References
- 24
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 4 · 2020: 4 · 2019: 3
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- pulmonary arterial hypertension, sleep apnea, nocturnal hypoxemia, prognosis, mortality, oxygen desaturation, left heart failure, pulmonary artery pressure
- MeSH terms
- Adult, Hypoxia, Female, Follow-Up Studies, Cardiac Catheterization, Humans, Hypertension, Pulmonary, Male, Middle Aged, Retrospective Studies, Sleep, Sleep Apnea Syndromes, Survival Rate, Disease-Free Survival
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