Pulsed Electromagnetic Fields Increase Angiogenesis and Improve Cardiac Function After Myocardial Ischemia in Mice
Open accessAbstract
BACKGROUND: Previous studies have shown that pulsed electromagnetic fields (PEMF) stimulate angiogenesis and may be a potential treatment strategy to improve cardiac function after myocardial infarction (MI). This study explored the effects and its related mechanisms of PEMF in MI mice. METHODS AND RESULTS: -eNOS), and increased the mRNA level of VEGF and hypoxia inducible factor 1-alpha (HIF-1α) in the infarct border zone. Additionally, treatment with 30 Hz 3.0 mT also increased protein and mRNA level of fibroblast growth factor 2 (FGF2), and protein level of β1 integrin, and shows a stronger therapeutic effect. CONCLUSIONS: PEMF treatment could promote angiogenesis of the infarct border zone and improve cardiac function in MI mice. A treatment parameter of 30 Hz 3.0 mT is remarkably effective in MI mice. The effect is associated with the proangiogenic signaling pathways of HIF-1α/VEGF/Akt/eNOS or HIF-1α/FGF2/Akt/eNOS.
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In preclinical models of myocardial infarction and ischemia-reperfusion injury, PEMF improves cardiac function, limits remodeling, and enhances angiogenesis.
“In preclinical models of myocardial infarction and ischemia–reperfusion injury, PEMF improved cardiac function, limited remodeling and enhanced angiogenesis [7,8,9,148].”
From The Heart’s Electromagnetic Field in Emotions, Empathy and Human Connection: Biosensor-Derived Insights into Heart–Brain Axis Mechanisms and a Basis for Novel BioMagnetoTherapies (2026) · cites this paper as [8]
The Discussion and the sections on cardiac function and infarct area report that PEMF improved function, reduced infarct size and increased angiogenesis in mice after myocardial infarction; the conclusion also says it limited infarct expansion. The Animals and MI Model section describes coronary-artery ligation, not an ischemia–reperfusion injury model, so this source does not support that part of the citing sentence. Page numbers were not available in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredPEMF therapy has cardioprotective and neuroprotective potential via enhancing cell survival, reducing inflammation and fibrosis, and promoting vascular repair and neuroplasticity.
“Pulsed electromagnetic field (PEMF) therapy has demonstrated cardioprotective and neuroprotective potential via enhancing cell survival, reducing inflammation and fibrosis and promoting vascular repair and neuroplasticity [7,8,9,10].”
From The Heart’s Electromagnetic Field in Emotions, Empathy and Human Connection: Biosensor-Derived Insights into Heart–Brain Axis Mechanisms and a Basis for Novel BioMagnetoTherapies (2026) · cites this paper as [8]
The Discussion reports reduced infarct size and improved cardiac function in mice after myocardial infarction, associated with increased angiogenesis; this supports cardioprotective potential and vascular repair. The paper says enhanced cardiomyocyte survival still needs investigation, and the cited passages do not establish reduced inflammation or fibrosis, neuroprotection, or neuroplasticity. (LLM, conf=0.87)
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- Authors
- Peng, L., Fu, C., Liang, Z., Zhang, Q., Xiong, F., Chen, L., He, C., & Wei, Q.
- Affiliations
- Sichuan University (CN)
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2020-01-24
- Volume
- 84
- Issue
- 2
- Pages
- 186-193
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W3000282234
- Cited by
- 32
- References
- 43
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 1 · 2021: 7 · 2020: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81572231)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- pulsed electromagnetic fields, myocardial ischemia, myocardial infarction, angiogenesis, cardiac function, infarct border zone, HIF-1α, vascular endothelial growth factor, endothelial nitric oxide synthase, FGF2, beta1 integrin, Akt signaling
- MeSH terms
- Animals, Disease Models, Animal, Electromagnetic Fields, Mice, Inbred C57BL, Myocardial Infarction, Myocardium, Phosphorylation, Signal Transduction, Fibroblast Growth Factor 2, Ventricular Function, Left, Neovascularization, Physiologic, Recovery of Function, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor A, Angiogenic Proteins, Proto-Oncogene Proteins c-akt, Hypoxia-Inducible Factor 1, alpha Subunit, Nitric Oxide Synthase Type III, Magnetic Field Therapy
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