Age-Adjusted Heart Rate Variability as an Index of the Severity and Prognosis of Heart Failure
Open accessAbstract
The age-adjusted, heart rate variability (HRV) was evaluated as a parameter for the severity of heart failure and its prognosis. HRV was obtained by 24-h Holter monitoring in patients with left ventricular dysfunction (LVD). New York Heart Association (NYHA) functional classification, echocardiography, radioisotope ventriculography, and blood examination were performed, and compared between patients and normal subjects. The evaluation was repeated during the follow-up period. Finally, using the lower limit of HRV, patients were divided into either normal or abnormal group for each low-frequency power (LF) and high-frequency power (HF) (age-adjusted HRV). Other parameters of heart failure and prognosis were compared between these 2 groups. HRV tended to be lower in patients with LVD. HF decreased at the early stage of heart failure, but did not decrease progressively. LF decreased progressively. HRV change paralleled the change of NYHA. The abnormal HRV group showed a poor prognosis for cardiac death, but not for sudden cardiac death. In patients with LVD, HRV was decreased compared with the normal subjects. Change in HRV correlated with the change in NYHA classification. Age-adjusted HRV correlated with cardiac-death prognosis, but not for sudden cardiac death.
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Sudden death, increased morbidity and mortality following cardiac surgery in hostile or depressed patients, and increased death rates in patients with sepsis or organ failure are linked clinically to decreased vagus nerve activity.
“Sudden death, increased morbidity and mortality following cardiac surgery in hostile or depressed patients, and increased death rates in patients with sepsis or organ failure are linked clinically to decreased vagus nerve activity (50)(51)(52)(53)(54).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [51]
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- Authors
- Soejima, K., Akaishi, M., Meguro, T., Oyamada, K., Yoshikawa, T., Mitamura, H., & Ogawa, S.
- Affiliations
- Keio University (JP)
- Venue
- Japanese Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2000
- Volume
- 64
- Issue
- 1
- Pages
- 32-38
- ISSN
- 0047-1828 (ISSN-L)
- 1347-4839
- OpenAlex
- W2094452355
- Cited by
- 32
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Japanese Circulation Journal-english Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- heart rate variability, heart failure, left ventricular dysfunction, heart failure severity, prognosis, cardiovascular mortality, sudden cardiac death, NYHA functional class, low-frequency power, high-frequency power, autonomic function
- MeSH terms
- Aged, Cardiomyopathy, Dilated, Cause of Death, Female, Follow-Up Studies, Heart Failure, Heart Rate, Humans, Male, Middle Aged, Myocardial Infarction, Prognosis, Reference Values, Regression Analysis, Severity of Illness Index, Time Factors, Electrocardiography, Ambulatory, Death, Sudden, Cardiac, Ventricular Dysfunction, Left
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