Nitric oxide donating compounds inhibit HCl-induced gastric mucosal lesions mainly via prostaglandin
Open accessAbstract
Prostaglandin (PG) and nitric oxide (NO) have been known to inhibit the lesion formation induced by necrotic agents. However, no clear correlation between PG and NO has been shown in the gastroprotective action against necrotic agent-induced gastric mucosal lesions in rats. Thus, the present study was performed to clarify this correlation. Gastric mucosal lesions were induced by the oral administration of 0.6 M HCl in rats. 16,16-Dimethyl PGE2 (0.3-3 microg/kg, p.o.; dim-PGE2), sodium nitrite (0.3 and 1 mg/kg, s.c.) and sodium nitroprusside (30 and 100 microg/kg, i.v.; SNP) dose-dependently inhibited the lesion formation. Orally administered sodium nitrite or SNP (3 mg/kg) also significantly inhibited the lesion formation. The gastroprotective action by dim-PGE2 was not affected by the pre-treatment with N(G)-nitro-L-arginine methylester (10 mg/kg, i.v.). The gastroprotective effect by sodium nitrite or SNP was markedly attenuated by the pre-treatment with indomethacin (10 mg/kg, s.c.). These findings suggest that NO donating compounds inhibit the HCl-induced mucosal lesions mainly through prostaglandin, but dim-PGE2 directly inhibits the lesions without involvement of NO in rats.
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- Authors
- Uchida, M., Matsueda, K., Shoda, R., Muraoka, A., & Yamato, S.
- Affiliations
- Meiji (Japan) (JP)
- International Medical Center in Jeddah (SA)
- Corresponding author
- Uchida, Masayuki
- ORCID
- Yamato, Shigeru
- Venue
- Japanese Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2001
- Volume
- 85
- Issue
- 2
- Pages
- 133-138
- ISSN
- 0021-5198 (ISSN-L)
- OpenAlex
- W2021267973
- Cited by
- 14
- References
- 20
- Citations by year
- 2021: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- The Japanese Journal of Pharmacology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- nitric oxide, nitric oxide donors, gastric mucosal lesions, prostaglandin E2, sodium nitrite, sodium nitroprusside, indomethacin, L-NAME, gastroprotection, gastric mucosal necrosis
- MeSH terms
- Administration, Oral, Animals, Gastric Mucosa, Hydrochloric Acid, Indomethacin, Male, Nitroprusside, Sodium Nitrite, Stomach Ulcer, 16,16-Dimethylprostaglandin E2, Rats, Sprague-Dawley, Nitric Oxide Donors, Rats
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