The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Current Research on Methamphetamine-Induced Neurotoxicity: Animal Models of Monoamine Disruption
Open accessAbstract
Methamphetamine (METH)-induced neurotoxicity is characterized by a long-lasting depletion of striatal dopamine (DA) and serotonin as well as damage to striatal dopaminergic and serotonergic nerve terminals. Several hypotheses regarding the mechanism underlying METH-induced neurotoxicity have been proposed. In particular, it is thought that endogenous DA in the striatum may play an important role in mediating METH-induced neuronal damage. This hypothesis is based on the observation of free radical formation and oxidative stress produced by auto-oxidation of DA consequent to its displacement from synaptic vesicles to cytoplasm. In addition, METH-induced neurotoxicity may be linked to the glutamate and nitric oxide systems within the striatum. Moreover, using knockout mice lacking the DA transporter, the vesicular monoamine transporter 2, c-fos, or nitric oxide synthetase, it was determined that these factors may be connected in some way to METH-induced neurotoxicity. Finally a role for apoptosis in METH-induced neurotoxicity has also been established including evidence of protection of bcl-2, expression of p53 protein, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), activity of caspase-3. The neuronal damage induced by METH may reflect neurological disorders such as autism and Parkinson's disease.
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McCann, U. D., Wong, D. F., Yokoi, F., Villemagne, V., Dannals, R. F., & Ricaurte, G. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08417.1998 · Cited by 602
Invited Review Free radicals and the pathobiology of brain dopamine systems
Cadet, J. L., & Brannock, C. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(97)00031-4 · Cited by 499
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Major physical and psychological harms of methamphetamine use
DARKE, S., KAYE, S., McKETIN, R., & DUFLOU, J. (2008) · Drug and Alcohol Review · doi:10.1080/09595230801923702 · Cited by 675
Brain Serotonin Transporter Density and Aggression in Abstinent Methamphetamine Abusers
Sekine, Y., Ouchi, Y., Takei, N., Yoshikawa, E., Nakamura, K., Futatsubashi, M., Okada, H., Minabe, Y., Suzuki, K., Iwata, Y., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.90 · Cited by 287
Potential adverse effects of amphetamine treatment on brain and behavior: a review
Berman, S. M., Kuczenski, R., McCracken, J. T., & London, E. D. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.90 · Cited by 261
Motaghinejad, M., Motevalian, M., Shabab, B., & Fatima, S. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-016-1623-5 · Cited by 46
Metadata
- Authors
- Kita, T., Wagner, G. C., & Nakashima, T.
- Venue
- Journal of Pharmacological Sciences
- Publisher
- Japanese Pharmacological Society
- Published
- 2003
- Volume
- 92
- Issue
- 3
- Pages
- 178-195
- ISSN
- 1347-8613 (ISSN-L)
- 1347-8648
- OpenAlex
- W1979947456
- Cited by
- 173
- References
- 2
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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