Cited by 44Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchSchizophrenia research and treatment

Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine- and cocaine-induced behavioral sensitization in mice

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Ago, Yukio, Nakamura, Shigeo, Baba, Akemichi, Matsuda, Toshio·2008·Journal of Pharmacological Sciences

Abstract

Repeated administration of psychostimulants elicits a progressive enhancement of locomotor activity known as behavioral sensitization. Central dopamine (DA) neurons play key roles as the neural substrates mediating behavioral sensitization, but the role of the serotonin (5-HT) system in the sensitization is not fully elucidated. We have recently demonstrated that osemozotan, a specific 5-HT(1A)-receptor agonist, and ritanserin, a 5-HT(2)-receptor antagonist, inhibited the expression and development of both methamphetamine- and cocaine-induced behavioral sensitization in mice and that these drugs attenuated the maintenance of behavioral sensitization of methamphetamine, but not that of cocaine. We also found that azasetron, a 5-HT(3)-receptor antagonist, inhibited the expression and development of the sensitization induced by methamphetamine and cocaine, respectively. Neurochemical studies using a microdialysis technique showed that repeated methamphetamine enhanced the methamphetamine-induced increase in 5-HT release in the prefrontal cortex. The sensitization of 5-HT release in methamphetamine-treated mice was attenuated by osemozotan and ritanserin. These findings suggest that the 5-HT system plays an important role in methamphetamine- and cocaine-induced behavioral sensitization in mice and imply that 5-HT(1A)-receptor agonists and 5-HT(2)-receptor antagonists may have a potential therapeutic value for the treatment of methamphetamine abuse or psychosis.

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  1. Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP. 5- HT2A and α1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioral sensitization to opiates and psychostimulants. Eur J Neurosci. 2004;20:3073- 3084.

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Authors
Ago, Y., Nakamura, S., Baba, A., & Matsuda, T.
Affiliations
The University of Osaka (JP)
Venue
Journal of Pharmacological Sciences
Published
2008
Volume
106
Issue
1
Pages
15-21
ISSN
  • 1347-8613 (ISSN-L)
  • 1347-8648
OpenAlex
W2008362610
Cited by
44
References
47
Citations by year
2024: 1 · 2023: 1 · 2021: 3 · 2019: 1 · 2017: 4 · 2016: 6 · 2014: 5 · 2013: 3 · 2012: 2
FWCI
0.50
Type
journal article
Language
en
Open access
Locations
  • Journal of Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
serotonergic system, behavioral sensitization, methamphetamine, cocaine, psychostimulants, 5-HT1A receptor agonist, 5-HT2 receptor antagonist, ritanserin, 5-HT3 receptor antagonists, azasetron, serotonin release, prefrontal cortex, locomotor activity, addiction treatment, psychosis
MeSH terms
Central Nervous System Stimulants, Animals, Behavior, Animal, Brain, Cocaine, Dioxanes, Dioxoles, Disease Models, Animal, Ligands, Methamphetamine, Motor Activity, Oxazines, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Ritanserin, Serotonin Receptor Agonists, Serotonin Agents, Bridged Bicyclo Compounds, Heterocyclic, Amphetamine-Related Disorders, Cocaine-Related Disorders, Mice, Serotonin 5-HT1 Receptor Agonists, Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT3 Receptor Antagonists

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