The Kallikrein-Kinin System: Current and Future Pharmacological Targets

Aminopeptidase P isozyme expression in human tissues and peripheral blood mononuclear cell fractions

Erşahin, Ç. H., Szpaderska, A. M., Orawski, A. T., & Simmons, W. H. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.12.023 · Cited by 54

Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease

Stadnicki, A., Pastucha, E., Nowaczyk, G., Mazurek, U. M., Plewka, D., Machnik, G., Wilczok, T., & Colman, R. W. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00369.2004 · Cited by 54

A Stable Metabolite, Arg-Pro-Pro-Gly-Phe, of Bradykinin in the Degradation Pathway in Human Plasma

Shima, C., Majima, M., & Katori, M. (1992) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.60.111 · Cited by 53

Current and future therapy for hereditary angioedema

Zuraw, B. L. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.08.001 · Cited by 53

Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans

Gainer, J. V., Brown, N. J., Bachvarova, M., Bastien, L., Maltais, I., Marceau, F., & Bachvarov, D. R. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)01215-2 · Cited by 53

The therapeutic potential of bradykinin B2 receptor agonists in the treatment of cardiovascular disease

Heitsch, H. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.5.759 · Cited by 53

Bradykinin metabolism in the postinfarcted rat heart: role of ACE and neutral endopeptidase 24.11

Raut, R., Rouleau, J. L., Blais, C., Gosselin, H., Molinaro, G., Sirois, M. G., Lepage, Y., Crine, P., & Adam, A. A. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.5.h1769 · Cited by 53

Participation of Hageman Factor Dependent Pathways in Human Disease States

Colman, R. W., & Wong, P. Y. (1977) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1651896 · Cited by 53

Structure−Activity Relationship of Hydroxamate-Based Inhibitors on the Secretases that Cleave the Amyloid Precursor Protein, Angiotensin Converting Enzyme, CD23, and Pro-Tumor Necrosis Factor-α

Parkin, E. T., Trew, A. J., Christie, G., Faller, A., Mayer, R. J., Turner, A. J., & Hooper, N. M. (2002) · Biochemistry · doi:10.1021/bi015936e · Cited by 52

Characterization of rat pulmonary vascular aminopeptidase P in vivo: role in the inactivation of bradykinin.

Ryan, J. W., Berryer, P., Chung, A. Y., & Sheffy, D. H. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38895-6 · Cited by 52

Generation of vasoactive peptide bradykinin from human umbilical vein endothelium-bound high molecular weight kininogen by plasma kallikrein

Nishikawa, K., Shibayama, Y., Kuna, P., Calcaterra, E., Kaplan, A. P., & Reddigari, S. (1992) · Blood · doi:10.1182/blood.v80.8.1980.1980 · Cited by 51

Two faces of high‐molecular‐weight kininogen (HK) in angiogenesis: bradykinin turns it on and cleaved HK (HKa) turns it off

GUO, Y., & Colman, R. W. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01218.x · Cited by 51

Tripeptidyl carboxypeptidase activity of kininase II (angiotensin-converting enzyme)

Inokuchi, J., & Nagamatsu, A. (1981) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(81)90042-5 · Cited by 51

Vasopeptidase inhibitors: an emerging class of cardiovascular drugs

Bralet, J., & Schwartz, J.-C. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01644-8 · Cited by 51

Benzodiazepines as Potent and Selective Bradykinin B1 Antagonists

Wood, M. R., Kim, J. J., Han, W., Dorsey, B. D., Homnick, C. F., DiPardo, R. M., Kuduk, S. D., MacNeil, T., Murphy, K. L., Lis, E. V., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm034020y · Cited by 51

The involvement of kallikrein–kinin system in diabetes type I (insulitis)

Zuccollo, A., Navarro, M., Frontera, M., Cueva, F., Carattino, M. D., & Catanzaro, O. L. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00149-6 · Cited by 50

Involvement of Bradykinin and Nitric Oxide in Leptin-Mediated Glucose Uptake in Skeletal Muscle

Shiuchi, T., Hironori Nakagami, A., Iwai, M., Takeda, Y., Cui, T., Chen, R., Minokoshi, Y., & Horiuchi, M. (2001) · Endocrinology · doi:10.1210/endo.142.2.7964 · Cited by 50

Endotoxin sensitization to kinin B1 receptor agonist in a non‐human primate model: haemodynamic and pro‐inflammatory effects

deBlois, D., & Horlick, R. A. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703748 · Cited by 49

Role of bradykinin B1 receptors in diabetes-induced hyperalgesia in streptozotocin-treated mice

Gabra, B. H., & Sirois, P. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02658-4 · Cited by 49

High-molecular-weight kininogen is exclusively membrane bound on endothelial cells to influence activation of vascular endothelium

Hasan, A., Cines, D., Ngaiza, J., Jaffe, E., & Schmaier, A. (1995) · Blood · doi:10.1182/blood.v85.11.3134.bloodjournal85113134 · Cited by 49

Characterization of two polymorphic sites in the human kinin B1 receptor gene

Bachvarov, D. R., Landry, M., Pelletier, I., Chevrette, M., Bétard, C., Houde, I., Bergeron, J., Lebel, M., & Marceau, F. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v94598 · Cited by 48

Effects of Captopril and Icatibant on Bradykinin (BK) and des[Arg9]BK in Carrageenan-Induced Edema

Décarie, A., Adam, A. A., & Couture, R. (1996) · Peptides · doi:10.1016/0196-9781(96)00145-3 · Cited by 48

Mapping Binding Domains of Kininogens on Endothelial Cell Cytokeratin 1

Shariat‐Madar, Z., Mahdi, F., & Schmaier, A. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7137 · Cited by 48

Aminopeptidase P from human leukocytes

Rusu, I., & Yaron, A. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17395.x · Cited by 48

Recent clinical trials with omapatrilat: New developments

Zanchi, A., Maillard, M. P., & Burnier, M. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0045-6 · Cited by 47

Human kininogens of low and high molecular mass: quantification by radioimmunoassay and determination of reference values.

Adam, A. A., Adam, A. A., Calay, G., Closset, J., Damas, J., & Franchimont, P. (1985) · Clinical Chemistry · doi:10.1093/clinchem/31.3.423 · Cited by 46

The common acute lymphoblastic leukemia antigen gene maps to chromosomal region 3 (q21-q27).

Barker, P. E., Shipp, M. A., D'adamio, L., Masteller, E. L., & Reinherz, E. L. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.1.283 · Cited by 45

Nonpeptide antagonists for kinin receptors

Altamura, M., Meini, S., Quartara, L., & Maggi, C. A. (1999) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00003-8 · Cited by 45

Expression of kinin B1receptor in fresh or cultured rabbit aortic smooth muscle: role of NF-κB

Sabourin, T., Morissette, G., Bouthillier, J., Lévesque, L., & Marceau, F. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00978.2001 · Cited by 45

Structure and Expression of Aminopeptidase N

Olsen, J., Kokholm, K., Norén, O., & Sjöström, H. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-9613-1_7 · Cited by 44

Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on different in vivo animal models of inflammation

Asano, M., Hatori, C., Inamura, N., Sawai, H., Hirosumi, J., Fujiwara, T., & Nakahara, K. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701534 · Cited by 44

Pharmacological characterization of the cardiovascular responses elicited by kinin B1 and B2 receptor agonists in the spinal cord of streptozotocin‐diabetic rats

Cloutier, F., & Couture, R. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703319 · Cited by 44

Inhibition of both aminopeptidase P and angiotensin-converting enzyme prevents bradykinin degradation in the rat coronary circulation

Erşahin, Ç., & Simmons, W. H. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199707000-00014 · Cited by 44

Hypotensive transfusion reactions can occur with blood products that are leukoreduced before storage

Arnold, D. M., Molinaro, G. A., Warkentin, T. E., Ditomasso, J., Webert, K. E., Davis, I., Lesiuk, L., Dunn, G. L., Heddle, N. M., Adam, A. A., et al. (2004) · Transfusion · doi:10.1111/j.0041-1132.2004.04057.x · Cited by 43

Inflammatory hyperalgesia induced by zymosan in the plantar tissue of the rat: effect of kinin receptor antagonists

Bélichard, P., Landry, M., Faye, P., Bachvarov, D. R., Bouthillier, J., Pruneau, D., & Marceau, F. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(99)00165-4 · Cited by 42

Molecular Cloning, Tissue Distribution, and Chromosomal Localization of MMEL2 , a Gene Coding for a Novel Human Member of the Neutral Endopeptidase-24.11 Family

Bonvouloir, N., Lemieux, N., Crine, P., Boileau, G., & DesGroseillers, L. (2001) · DNA and Cell Biology · doi:10.1089/104454901316976127 · Cited by 42

An ACE structure

Hooper, N. M., & Turner, A. J. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb0303-155 · Cited by 41

Kinin B1 receptor antagonists inhibit diabetes-induced hyperalgesia in mice

Gabra, B. H., & Sirois, P. (2003) · Neuropeptides · doi:10.1016/s0143-4179(02)00148-8 · Cited by 41

Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins.

Drapeau, G., Audet, R., Lévesque, L., Godin, D., & Marceau, F. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38337-0 · Cited by 41

Regulation of bradykinin receptor gene expression in human lung fibroblasts

Phagoo, S. B., Yaqoob, M., Herrero‐Martínez, E., McIntyre, P., Jones, C. E., & Burgess, G. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00323-x · Cited by 40

Should all patients with coronary disease receive angiotensin-converting-enzyme inhibitors?

White, H. D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14295-x · Cited by 40

Purification and properties of human low molecular weight kininogen

Müller‐Esterl, W., Vohle-Timmermann, M., Boos, B., & Dittman, B. (1982) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(82)90480-0 · Cited by 39

Basal expression of bradykinin B1 receptor in the spinal cord in humans and rats

Ma, Q., & HEAVENS, R. P. (2001) · Neuroreport · doi:10.1097/00001756-200108080-00006 · Cited by 39

A Novel Class of Orally Active Non-Peptide Bradykinin B2 Receptor Antagonists. 2. Overcoming the Species Difference between Guinea Pig and Man

Abe, Y., Kayakiri, H., Satoh, S., Inoue, T., Sawada, Y., Inamura, N., Asano, M., Hatori, C., Sawai, H., Oku, T., et al. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980214f · Cited by 39

A review of the angiotensin-converting enzyme inhibitor, zofenopril, in the treatment of cardiovascular diseases

Borghi, C., Bacchelli, S., Esposti, D. D., & Ambrosioni, E. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.9.1965 · Cited by 39

The modulatory effects of Bradykinin B1 and B2 receptor antagonists upon viscero-visceral hyper-reflexia in a rat model of visceral hyperalgesia

Jaggar, S., Habib, S., & Rice, A. S. C. (1998) · Pain · doi:10.1016/s0304-3959(97)00217-0 · Cited by 38

Sequence variation of bradykinin receptors B1 and B2 and association with hypertension

Cui, J., Melista, E., Chazaro, I., Zhang, Y., Zhou, X. C., Manolis, A. J., Baldwin, C. T., DeStefano, A. L., & Gavras, H. P. (2005) · Journal of Hypertension · doi:10.1097/00004872-200501000-00013 · Cited by 38

Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: An in situ hybridization study

Shughrue, P. J., Ky, B., & Austin, C. P. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10846 · Cited by 38

Genomic Structure of the Human Bradykinin B1Receptor Gene and Preliminary Characterization of Its Regulatory Regions

Yang, X., & POLGAR, P. R. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0810 · Cited by 38

Cloning and tissue distribution of human membrane-bound aminopeptidase P

Venema, R. C., Ju, H., Zou, R., Venema, V. J., & Ryan, J. W. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(97)00126-7 · Cited by 37

Altered frequency of a promoter polymorphic allele of the kinin B receptor gene in inflammatory bowel disease

Bachvarov, D. R., Landry, M., Houle, S., Paré, P., & Marceau, F. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70071-x · Cited by 37

Bradykinin B2receptor gene polymorphism is associated with altered urinary albumin/creatinine values in diabetic patients

Maltais, I., Bachvarova, M., Maheux, P., Perron, P., Marceau, F., & Bachvarov, D. R. (2002) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y02-036 · Cited by 37

Comparison of a Vasopeptidase Inhibitor with Neutral Endopeptidase and Angiotensin-Converting Enzyme Inhibitors on Bradykinin Metabolism in the Rat Coronary Bed

Dumoulin, M., Adam, A. A., Rouleau, J. L., & Lamontagne, D. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200104000-00002 · Cited by 37

Structure of the mammalian kinin receptor gene locus

Cayla, C., Merino, V. F., Cabrini, D. A., Silva, J. A., Pesquero, J. B., & Bäder, M. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00175-3 · Cited by 35

Over-expression of angiotensin converting enzyme-1 augments cardiac hypertrophy in transgenic rats

Tian, X. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh147 · Cited by 35

Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates

MOLINARO, G., Carmona, A. K., Juliano, M. A., Juliano, L., Malitskaya, E., Yessine, M., Chagnon, M., LEPAGE, Y., Simmons, W. H., Boileau, G., et al. (2005) · Biochemical Journal · doi:10.1042/bj20040849 · Cited by 35

Heavy chain of human high molecular weight and low molecular weight kininogens binds calcium ion

Higashiyama, S., Ohkubo, I., Ishiguro, H., Sasaki, M., Matsuda, T., & Nakamura, R. (1987) · Biochemistry · doi:10.1021/bi00397a038 · Cited by 34

Application of a new anticoagulant (nafamostat mesilate) to control hemorrhagic complications during extracorporeal membrane oxygenation—A preliminary report

Nagaya, M., Futamura, M., Kato, J., Niimi, N., & Fukuta, S. (1997) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(97)90701-6 · Cited by 34

Assignment of the Membrane-Bound Human Aminopeptidase P Gene (XPNPEP2) to Chromosome Xq25

Sprinkle, T. J., Stone, A. A., Venema, R. C., Denslow, N. D., Caldwell, C., & Ryan, J. W. (1998) · Genomics · doi:10.1006/geno.1998.5302 · Cited by 34

p38 stress-activated protein kinase inhibitor reverses bradykinin B1 receptor-mediated component of inflammatory hyperalgesia

Ganju, P., Aj, D., Patel, S., Núñez, X., & Fox, A. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01048-2 · Cited by 34

L-755,807, A new non-peptide bradykinin binding inhibitor from an endophytic Microsphaeropsis sp.

LAM, Y. K. T., Hensens, O. D., Ransom, R. W., GIACOBBE, R. A., Polishook, J. D., & Zink, D. L. (1996) · Tetrahedron · doi:10.1016/0040-4020(95)00985-x · Cited by 34

The Preparation and Characterization of Novel Peptide Antagonists to Thrombin and Factor VIIa and Activation of Protease-Activated Receptor 1

Nieman, M. T., Warnock, M., Hasan, A., Mahdi, F., Lucchesi, B. R., Brown, N. J., Murphey, L. J., & Schmaier, A. H. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.069229 · Cited by 34

Vasopeptidase inhibitors: a new class of dual zinc metallopeptidase inhibitors for cardiorenal therapeutics.

Molinaro, G., Rouleau, J., & Adam, A. (2002) · Current opinion in pharmacology (Print) · doi:10.1016/s1471-4892(02)00138-8 · Cited by 33

Activation of the contact system and inflammation after thrombolytic therapy in patients with acute myocardial infarction

Merlini, P. A., Cugno, M., Rossi, M. L., Agricola, P. M. G., Repetto, A., Fetiveau, R., Diotallevi, P., Canosi, U., Mannucci, P. M., & Ardissino, D. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.12.017 · Cited by 33

Changes in hippocampal and cortical B1 bradykinin receptor biological activity in two experimental models of epilepsy

Bregola, G., Varani, K., Gessi, S., Beani, L., Bianchi, C., Borea, P. A., Regoli, D. C., & Simonato, M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00075-5 · Cited by 32

Kinetic Analysis of the Role of Zinc in the Interaction of Domain 5 of High-Molecular Weight Kininogen (HK) with Heparin

Lin, Y., Pixley, R. A., & Colman, R. W. (2000) · Biochemistry · doi:10.1021/bi992048z · Cited by 32

Roles for the Kallikrein-Kinin System in Inflammatory Exudation and Pain: Lessons From Studies on Kininogen-Deficient Rats

Ueno, A., & Oh‐ishi, S. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.1 · Cited by 32

Hereditary angioedema type III, angioedema associated with angiotensin II receptor antagonists, and female sex.

Bork, K., & Dewald, G. (2004) · American Journal of Medicine · doi:10.1016/j.amjmed.2003.11.031 · Cited by 32

B2 bradykinin receptor (B2BKR) polymorphism and change in left ventricular mass in response to antihypertensive treatment

Hallberg, P., Lind, L., Michaëlsson, K., Karlsson, J., Kurland, L., Kahan, T., Malmqvist, K. K., Öhman, K. P., Nyström, F. H., & Melhus, H. (2003) · Journal of Hypertension · doi:10.1097/00004872-200303000-00029 · Cited by 31

Posttranslational Modification of Glycosylphosphatidylinositol (GPI)-Specific Phospholipase D and Its Activity in Cleavage of GPI Anchors

Tujioka, H., Misumi, Y., Takami, N., & Ikehara, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9542 · Cited by 30

Potent and Orally Bioavailable Non-Peptide Antagonists at the Human Bradykinin B1 Receptor Based on a 2-Alkylamino-5-sulfamoylbenzamide Core

Ritchie, T. J., Dziadulewicz, E. K., Culshaw, A. J., Müller, W., Burgess, G. M., Bloomfield, G. C., Drake, G. S., Dunstan, A. R., Beattie, D. T., Hughes, G. A., et al. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049747g · Cited by 30

Bradykinin-Dependent Cardioprotective Effects of Losartan Against Ischemia and Reperfusion in Rat Hearts

Zhu, P., Zaugg, C. E., Hornstein, P. S., ALLEGRINI, P. R., & Buser, P. T. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199905000-00016 · Cited by 30

Effect of Allelic Polymorphism of the B1 and B2 Receptor Genes on the Contractile Responses of the Human Umbilical Vein to Kinins

Houle, S., Landry, M., Audet, R., Bouthillier, J., Bachvarov, D. R., & Marceau, F. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39038-x · Cited by 29

Small molecule antagonists of the bradykinin B1 receptor

Horlick, R. A., Ohlmeyer, M. H. J., Stroke, I. L., Strohl, B., Pan, G., Schilling, A. E., Paradkar, V. M., Quintero, J. G., You, M., Riviello, C. M., et al. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00130-7 · Cited by 29

Activation of mitogen‐activated protein kinase by the bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation‐triggered internalization

Blaukat, A., Pizard, A., Rajerison, R. M., Alhenc‐Gelas, F., Müller‐Esterl, W., & Đikić, I. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00613-4 · Cited by 28

Changes in paw oedema triggered via bradykinin B1 and B2 receptors in streptozotocin-diabetic rats

Campos, M. M., Cabrini, D. A., Cardozo, A. M., Rae, G. A., Toro, J. P. G. H., & Calixto, J. Β. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00883-4 · Cited by 28

Studies on Human High Molecular Weight (HMW) Kininogen. III. Cleavage of HMW Kininogen by the Action of Human Salivary Kallikrein

Kazumine, M. O. R. I., Sakamoto, W., & Nagasawa, S. (1981) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a133498 · Cited by 27

A study of the mediators involved in the protection induced by exogenous kinins in the isolated rat heart

Lagneux, C., Adam, A. A., & Lamontagne, D. (2003) · International Immunopharmacology · doi:10.1016/s1567-5769(03)00177-2 · Cited by 27

A Novel Nonpeptide Antagonist of the Kinin B1 Receptor: Effects at the Rabbit Receptor

Morissette, G., Fortin, J., Otis, S., Bouthillier, J., & Marceau, F. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.071266 · Cited by 27

Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists

Landgraf, R. G., Jancar, S., Steil, A. A., & Sirois, P. (2004) · Inflammation Research · doi:10.1007/s00011-003-1226-0 · Cited by 26

A study of the action of bradykinin and bradykinin analogues in the human nasal airway.

Austin, C. E., & Foreman, J. C. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020255 · Cited by 26

Aminopeptidase P – a Cell-Surface Antigen of Endothelial and Lymphoid Cells: Catalytic and Immuno-Histotopical Evidences

Lasch, J., Moschner, S., Sann, H., Zellmer, S., & Koelsch, R. (1998) · Biological Chemistry · doi:10.1515/bchm.1998.379.6.705 · Cited by 26

Implication of the bradykinin receptors in antigen‐induced pulmonary inflammation in mice

Eric, J., Gabra, B. H., & Sirois, P. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705207 · Cited by 26

Tissue Kallikrein Actions at the Rabbit Natural or Recombinant Kinin B 2 Receptors

Houle, S., Molinaro, G., Adam, A. A., & Marceau, F. (2003) · Hypertension · doi:10.1161/01.hyp.0000054971.03046.9b · Cited by 26

Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins

FOGAÇA, S. E., Melo, R. L. D., Pimenta, D. C., Hosoi, K., Juliano, L., & Juliano, M. A. (2004) · Biochemical Journal · doi:10.1042/bj20031047 · Cited by 26

Respiratory effects of angiotensin converting enzyme inhibition

Berkin, K. (1989) · European Respiratory Journal · doi:10.1183/09031936.93.02030198 · Cited by 26

Dipeptidyl aminopeptidase IV and aminopeptidase P, two proline specific enzymes from the cytoplasm of guinea-pig brain: their role in metabolism of peptides containing consecutive prolines

Gilmartin, L., & O’Cuinn, G. (1999) · Neuroscience Research · doi:10.1016/s0168-0102(99)00025-5 · Cited by 25

Aminopeptidase P is disposed on human endothelial cells

Ryan, J. W., Papapetropoulos, A., Ju, H., Denslow, N. D., Antonov, A., Virmani, R., Kolodgie, F. D., Gerrity, R. G., & Catravas, J. D. (1996) · Immunopharmacology · doi:10.1016/0162-3109(95)00078-x · Cited by 25

Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2

Sprinkle, T. J., Caldwell, C., & Ryan, J. W. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1792 · Cited by 25

Genetic Variation in the Promoter Region of the .BETA.2 Bradykinin Receptor Gene Is Associated with Essential Hypertension in a Chinese Han Population.

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