Cited by 469Coagulation, Bradykinin, Polyphosphates, and AngioedemaPineapple and bromelain studiesComplement system in diseases

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The Kallikrein-Kinin System: Current and Future Pharmacological Targets

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Moreau, Marie Eve, Garbacki, Nancy, Molinaro, Giuseppe, Brown, Nancy J., Marceau, François, Adam, Albert·2005·Journal of Pharmacological Sciences

DOI 10.1254/jphs.srj05001x

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Abstract

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins. The pharmacologically active kinins, which are often considered as either proinflammatory or cardioprotective, are implicated in many physiological and pathological processes. The interest of the various components of this multi-protein system is explained in part by the multiplicity of its pharmacological activities, mediated not only by kinins and their receptors, but also by their precursors and their activators and the metallopeptidases and the antiproteases that limit their activities. The regulation of this system by serpins and the wide distribution of the different constituents add to the complexity of this system, as well as its multiple relationships with other important metabolic pathways such as the renin-angiotensin, coagulation, or complement pathways. The purpose of this review is to summarize the main properties of this kallikrein-kinin system and to address the multiple pharmacological interventions that modulate the functions of this system, restraining its proinflammatory effects or potentiating its cardiovascular properties.

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Authors: Moreau, M. E., Garbacki, N., Molinaro, G., Brown, N. J., Marceau, F., & Adam, A.
Affiliations: Université de Montréal (CA)
University of Liège (BE)
Vanderbilt University (US)
Centre hospitalier universitaire de Québec (CA)
ORCID: Garbacki, Nancy
Brown, Nancy J.
Marceau, François
Adam, Albert
Venue: Journal of Pharmacological Sciences
Publisher: Japanese Pharmacological Society
Published: 2005
Volume: 99
Issue: 1
Pages: 6-38
ISSN: 1347-8613 (ISSN-L)
1347-8648
DOI: 10.1254/jphs.srj05001x
OpenAlex: W1967632907
Semantic Scholar: 11ef9af17a7b09227baf4d743022d17406b6c59a
Cited by: 457
References: 324
Citations by year: 2026: 2 · 2025: 9 · 2024: 19 · 2023: 14 · 2022: 7 · 2021: 20 · 2020: 24 · 2019: 9 · 2018: 20 · 2017: 13 · 2016: 29 · 2015: 23 · 2014: 24 · 2013: 37 · 2012: 33
FWCI: 4.07
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Pharmacological Sciences (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
ORBi (University of Liège) (submittedVersion, other-oa)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL079184)
Topics: Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pineapple and bromelain studies
Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Keywords: kallikrein-kinin system, bradykinin, kininogen, tissue kallikrein, plasma kallikrein, kinin receptors, metalloproteinases, antiproteases, serpins, pro-inflammatory effects, cardioprotection, renin-angiotensin system, coagulation, complement system, therapeutic target
MeSH terms: Angioedema, Angiotensin-Converting Enzyme Inhibitors, Animals, Bradykinin, Cardiovascular Diseases, Complement C1 Inactivator Proteins, Humans, Inflammation, Kallikreins, Aprotinin, Kidney Diseases, Peptidyl-Dipeptidase A, Kinins, Polymorphism, Genetic, Pyridines, Thiazepines, Neprilysin, Serpins, Randomized Controlled Trials as Topic, Kallikrein-Kinin System, Receptor, Bradykinin B2, Receptor, Bradykinin B1, Complement C1 Inhibitor Protein, Bradykinin B2 Receptor Antagonists

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The Kallikrein-Kinin System: Current and Future Pharmacological Targets

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