The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Adult Reference Ranges for Serum Cystatin C, Creatinine and Predicted Creatinine Clearance
Open accessAbstract
Serum cystatin C measurement has been previously shown by ourselves and others to be a better indicator of changes in glomerular filtration rate (GFR) than serum creatinine. However, the available literature on reference values for cystatin C concentration remains surprisingly sparse; we thus set out to determine an adult reference range. Blood was taken from 309 healthy blood donors and creatinine and cystatin C concentrations were measured using commercially available automated methodologies. In addition, predicted creatinine clearances were calculated using the Cockcroft and Gault formula. The 95% reference intervals for creatinine, predicted creatinine clearance and cystatin C for all blood donors, regardless of gender, were 68–118 μmol/L, 58–120 ml/min/1·73 m 2 and 0·51–0·98 mg/L, respectively. For women, the intervals were 68–98 μmol/L, 60–119 ml/min/1·73 m 2 and 0·49–0·94 mg/L; for men, they were 78–123 μmol/L, 57–122 ml/min/1·73 m 2 and 0·56–0·98 mg/L. The mean 95% reference interval for cystatin C in all donors under 50 years of age was 0·53–0·92 mg/L; for those over 50 years of age it was 0·58–1·02 mg/L. The small difference between male and female ranges meant that a single reference range for cystatin C could be established for all adults under 50 years of age without adjustment for body surface area. Serum cystatin C measurement offers a simpler and more sensitive screening test than serum creatinine for early changes in GFR.
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Cites
Prediction of Creatinine Clearance from Serum Creatinine
Cockcroft, D. W., & Gault, H. (1976) · Nephron · doi:10.1159/000180580 · Cited by 15,309
Levey, A. S., Bosch, J. P., Lewis, J. B., Greene, T., Rogers, N., Roth, D., & for the Modification of Diet in Renal Disease Study Group* (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00002 · Cited by 15,079
EDF Statistics for Goodness of Fit and Some Comparisons
Stephens, M. A. (1974) · Journal of the American Statistical Association · doi:10.1080/01621459.1974.10480196 · Cited by 3,166
The Effect of Age on Creatinine Clearance in Men: A Cross-sectional and Longitudinal Study
Rowe, J. W., Andres, R., Tobin, J. D., Norris, A. H., & Shock, N. W. (1976) · Journal of Gerontology · doi:10.1093/geronj/31.2.155 · Cited by 1,104
Creatinine assay by a reaction-kinetic principle
Larsen, K. (1972) · Clinica Chimica Acta · doi:10.1016/0009-8981(72)90513-x · Cited by 654
Newman, D. J., Thakkar, H., Edwards, R. G., Wilkie, M., White, T., Grubb, A. O., & Price, C. P. (1995) · Kidney International · doi:10.1038/ki.1995.40 · Cited by 650
Self-citationStructure and expression of the human cystatin C gene
Abrahamson, M., Olafsson, I., Palsdottir, A., Ulvsbäck, M., Lundwall, Å., Jensson, O., & Grubb, A. (1990) · Biochemical Journal · doi:10.1042/bj2680287 · Cited by 612
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A clinical appraisal of the plasma concentration and endogenous clearance of creatinine
Doolan, P. D., Alpen, E. L., & Theil, G. B. (1962) · The American Journal of Medicine · doi:10.1016/0002-9343(62)90183-3 · Cited by 371
The blood serum concentration of cystatin C (γ-trace) as a measure of the glomerular filtration rate
Simonsen, O., Grubb, A., & Thysell, H. (1985) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518509160980 · Cited by 337
Cited by
Risch, L., Herklotz, R., Blumberg, A., & Huber, A. R. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.11.2055 · Cited by 343
Biochemistry and Clinical Role of Human Cystatin C
Mussap, M., & Plebani, M. (2004) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360490504934 · Cited by 313
Shen, R., Zhang, W., Ming, S., Li, L., Peng, Y., & Gao, X. (2021) · Urolithiasis · doi:10.1007/s00240-020-01190-x · Cited by 8
Metadata
- Authors
- Finney, H., Newman, D. J., & Price, C. P.
- Venue
- Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
- Publisher
- SAGE Publications
- Published
- 2000-01
- Volume
- 37
- Issue
- 1
- Pages
- 49-59
- ISSN
- 0004-5632 (ISSN-L)
- 1758-1001
- OpenAlex
- W2071643528
- Cited by
- 287
- References
- 26
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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