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Pathology of small vessel stroke
Abstract
Disease of small intracerebral vessels is widely assumed to be responsible for the majority of small, deep-seated (lacunar) infarcts and primary intracerebral haemorrhages. Our present, limited understanding of the pathogenesis of these stroke subtypes, which together constitute up to one-third of all strokes, is based on a limited number of detailed pathology studies, supported by clinical, risk factor and imaging data. Further progress using these traditional approaches has been prevented by a variety of largely technical obstacles. It is suggested that advances in our understanding of the genetic basis of established and new animal stroke models, in turn linked to more focused human genetic stroke surveys, may hold the key to further insights.
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“In humans, damage to microvessels is a known pathological condition [50–54].”
From Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion (2006) · cites this paper as [50]
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Metadata
- Authors
- Alistair Lammie, G.
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 56
- Issue
- 2
- Pages
- 296-306
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2096193226
- Cited by
- 133
- References
- 25
- Citations by year
- 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 11 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Medical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- cerebral small vessel disease, lacunar infarction, intracerebral hemorrhage, stroke pathogenesis, animal models of stroke
- MeSH terms
- Cerebral Hemorrhage, Cerebral Infarction, Humans, Stroke
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