The Impact of C-Reactive Protein on Risk of Stroke, Stroke Subtypes, and Ischemic Heart Disease in Middle-Aged Japanese: the Japan Public Health Center-Based Study
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AIM: To examine the impact of C-reactive protein on the risks of stroke and its subtypes, particularly among Asian populations in which median C-reactive protein levels are typically lower than in Western populations. METHODS: A prospective, nested case-control study was conducted to examine the associations between high sensitivity-CRP (hs-CRP) and risks of cardiovascular disease within a cohort of 29,876 men and women aged 40-69 years, with no history of stroke, ischemic heart disease or cancer, who submitted blood samples between 1990 and 1993. Systematic cardiovascular surveillance was performed throughout 2007. One control for each stroke and two controls for each ischemic heart disease were matched for sex, age, date of blood drawing, time since last meal and study location. RESULTS: We documented 1,132 incident strokes (638 ischemic and 494 hemorrhagic strokes) and 209 ischemic heart diseases (168 myocardial infarctions and 41 sudden cardiac deaths), and observed a linear association between hs-CRP levels and risks of ischemic stroke and ischemic heart disease, more specifically myocardial infarction. The multivariable odds ratios associated with 1-SD increment of logarithmically transformed hs-CRP were 1.13 (0.99-1.29),p= 0.07 for ischemic stroke, 1.16 (0.96-1.41),p= 0.13 for lacunar infarction, 1.41 (0.98-2.01),p= 0.06 for embolic infarction, and 1.28 (1.03-1.59),p= 0.03 for myocardial infarction. The predictive value of hs-CRP for ischemic stroke was reduced primarily after adjustment for hypertensive status and body mass index. No association was found between hs-CRP levels and the risk of hemorrhagic or total stroke. CONCLUSIONS: High serum hs-CRP levels were associated with the risk of myocardial infarction and more weakly with the risk of ischemic stroke among middle-aged Japanese men and women.
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There are reports in Japan stating that a significant association was seen between hs-CRP and stroke (especially cerebral infarction and lacunar infarction).
“There are reports in Japan stating that a significant association was seen between hs-CRP and stroke (especially cerebral infarction and lacunar infarction)280).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [280]
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Hiwasa, T., Li, S., Kubota, M., Zhang, B., Yoshida, Y., Kobayashi, E., Matsutani, T., Mine, S., Machida, T., Ito, M., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-277178/v1
Self-citationKatayose, R., Okura, M., Kinoshita, A., Arai, H., & Ogita, M. (2023) · Research Square · doi:10.21203/rs.3.rs-2562034/v1
A comprehensive retrospect on biomarkers indicating vascular failure
Sakuma, M., Masaki, N., Yano, S., Shimabukuro, M., Yamaoka‐Tojo, M., Fukuda, D., Hironori Nakagami, A., Node, K., & Sata, M. (2024) · Vascular Failure · doi:10.30548/vascfail.8.1_24
- Authors
- Iso, H., Noda, H., Ikeda, A., Yamagishi, K., Inoue, M., Iwasaki, M., & Tsugane, S.
- Affiliations
- The University of Osaka (JP)
- Harvard University (US)
- University of Tsukuba (JP)
- National Cancer Center (US)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2012
- Volume
- 19
- Issue
- 8
- Pages
- 756-66
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W1979505684
- Cited by
- 48
- References
- 41
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 2
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (19390174)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- C-reactive protein, high-sensitivity C-reactive protein, stroke, ischemic stroke, hemorrhagic stroke, ischemic heart disease, myocardial infarction, lacunar infarction, embolic infarction, middle-aged adults, Japanese population, inflammation, cardiovascular risk
- MeSH terms
- Adult, Aged, C-Reactive Protein, Female, Follow-Up Studies, Humans, Ischemia, Japan, Male, Middle Aged, Myocardial Infarction, Prognosis, Prospective Studies, Risk Factors, Biomarkers, Case-Control Studies, Stroke
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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