Cited by 48Lipoproteins and Cardiovascular HealthAcute Ischemic Stroke ManagementInflammatory Biomarkers in Disease Prognosis

The Impact of C-Reactive Protein on Risk of Stroke, Stroke Subtypes, and Ischemic Heart Disease in Middle-Aged Japanese: the Japan Public Health Center-Based Study

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Iso, Hiroyasu, Noda, Hiroyuki, Ikeda, Ai, Yamagishi, Kazumasa, Inoue, Manami, Iwasaki, Motoki, Tsugane, Shoichiro·2012·Journal of Atherosclerosis and Thrombosis

Abstract

AIM: To examine the impact of C-reactive protein on the risks of stroke and its subtypes, particularly among Asian populations in which median C-reactive protein levels are typically lower than in Western populations. METHODS: A prospective, nested case-control study was conducted to examine the associations between high sensitivity-CRP (hs-CRP) and risks of cardiovascular disease within a cohort of 29,876 men and women aged 40-69 years, with no history of stroke, ischemic heart disease or cancer, who submitted blood samples between 1990 and 1993. Systematic cardiovascular surveillance was performed throughout 2007. One control for each stroke and two controls for each ischemic heart disease were matched for sex, age, date of blood drawing, time since last meal and study location. RESULTS: We documented 1,132 incident strokes (638 ischemic and 494 hemorrhagic strokes) and 209 ischemic heart diseases (168 myocardial infarctions and 41 sudden cardiac deaths), and observed a linear association between hs-CRP levels and risks of ischemic stroke and ischemic heart disease, more specifically myocardial infarction. The multivariable odds ratios associated with 1-SD increment of logarithmically transformed hs-CRP were 1.13 (0.99-1.29),p= 0.07 for ischemic stroke, 1.16 (0.96-1.41),p= 0.13 for lacunar infarction, 1.41 (0.98-2.01),p= 0.06 for embolic infarction, and 1.28 (1.03-1.59),p= 0.03 for myocardial infarction. The predictive value of hs-CRP for ischemic stroke was reduced primarily after adjustment for hypertensive status and body mass index. No association was found between hs-CRP levels and the risk of hemorrhagic or total stroke. CONCLUSIONS: High serum hs-CRP levels were associated with the risk of myocardial infarction and more weakly with the risk of ischemic stroke among middle-aged Japanese men and women.

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  1. vey of Stroke. Clinical findings. Stroke 1981; 12: 113-144
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Authors
Iso, H., Noda, H., Ikeda, A., Yamagishi, K., Inoue, M., Iwasaki, M., & Tsugane, S.
Affiliations
  • The University of Osaka (JP)
  • Harvard University (US)
  • University of Tsukuba (JP)
  • National Cancer Center (US)
Venue
Journal of Atherosclerosis and Thrombosis
Published
2012
Volume
19
Issue
8
Pages
756-66
ISSN
  • 1340-3478 (ISSN-L)
  • 1880-3873
OpenAlex
W1979505684
Cited by
48
References
41
Citations by year
2025: 2 · 2024: 3 · 2023: 2 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 2
FWCI
5.54
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (19390174)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
C-reactive protein, high-sensitivity C-reactive protein, stroke, ischemic stroke, hemorrhagic stroke, ischemic heart disease, myocardial infarction, lacunar infarction, embolic infarction, middle-aged adults, Japanese population, inflammation, cardiovascular risk
MeSH terms
Adult, Aged, C-Reactive Protein, Female, Follow-Up Studies, Humans, Ischemia, Japan, Male, Middle Aged, Myocardial Infarction, Prognosis, Prospective Studies, Risk Factors, Biomarkers, Case-Control Studies, Stroke

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