Life span of specified-pathogen-free (MRC category 4) mice and rats
Abstract
Data are presented on the life span and pathology of 15 inbred and 2 outbred strains of mice, and 1 inbred and 1 outbred strain of rats, maintained under specified-pathogen-free (SPF) conditions. Among the mice, longevity ranged from 312 to 802 days. Survival curves for each strain are given. Neoplasia was the most common pathological finding.
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Sex was a strong determinant of lifespan, as females outlived the males in 14 out of the 19 strains, although no significant difference was detected in the remaining 5 strains.
“Moreover, sex was a strong determinant of lifespan, as females outlived the males in 14 out of the 19 strains, although no significant difference was detected in the remaining 5 strains (Festing and Blackmore, 1971).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Festing and Blackmore, 1971
A longevity study performed on 19 strains of specific-pathogen-free mice and rats showed marked differences in lifespan ranging from 312 to 782 days within the mouse strains.
“For example, a longevity study performed on 19 strains of specificpathogen-free mice and rats showed marked differences in lifespan ranging from 312 to 782 days within the mouse strains (Festing and Blackmore, 1971).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Festing and Blackmore, 1971
Cites
The Biology of the Laboratory Mouse
Weiner, W. J. (1957) · Journal of Clinical Pathology · doi:10.1136/jcp.10.3.288-b · Cited by 54 · see citing works
Factors Modifying the Lifespan of Mice
Silberberg, M., & Silberberg, R. (1954) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1954.177.1.23 · Cited by 28 · see citing works
Festing, M. F. W. (1969) · Nature · doi:10.1038/221716a0 · Cited by 9 · see citing works
Self-citationDiseases of the Female Reproductive System
Fluhmann, C. F. (1953) · Annual Review of Medicine · doi:10.1146/annurev.me.04.020153.001215 · Cited by 2 · see citing works
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Microglia Priming with Aging and Stress
Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398 · see citing works
Animal models of aging research: implications for human aging and age-related diseases
Mitchell, S. J., Scheibye-Knudsen, M., Longo, D. L., & de Cabo, R. (2015) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022114-110829 · Cited by 328 · see citing works
- Authors
- Festing, M. F. W., & Blackmore, D. K.
- Affiliations
- Medical Research Council (GB)
- ORCID
- Festing, M. F. W.
- Venue
- Laboratory Animals
- Publisher
- SAGE Publications
- Published
- 1971-10-01
- Volume
- 5
- Issue
- 2
- Pages
- 179-192
- ISSN
- 0023-6772 (ISSN-L)
- 1758-1117
- OpenAlex
- W2047270734
- Cited by
- 95
- References
- 4
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Laboratory Animals (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Keywords
- lifespan, longevity, survival curves, inbred strains, mice, rats, cancer, pathology, laboratory animal health
- MeSH terms
- Analysis of Variance, Animals, Animals, Laboratory, Bacterial Infections, Female, Germ-Free Life, Housing, Animal, Longevity, Male, Mice, Inbred Strains, Neoplasms, Rats, Inbred Strains, Rodent Diseases, Sex Factors, Mice, Rats
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