Consumptive hypothyroidism: a case report and review of the literature
Abstract
Hepatic haemangioendothelioma is a rare vascular tumour in infants and may be associated with a unique form of thyroid function abnormalities. Hepatic haemangioendotheliomata is capable of producing an excess of the thyroid hormone inactivating enzyme, type 3 iodothyronine deiodinase. The increased enzyme activity leads to rapid degradation of thyroid hormones, resulting in frank hypothyroidism. We report a case of a three-month-old neonate with multiple hepatic haemangioendotheliomata and associated hypothyroidism. The patient required increasing doses of thyroid hormone.
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Consumptive hypothyroidism usually requires aggressive thyroid replacement with gradual LT4 dose increases until TSH normalizes, and TSH should be measured more frequently than usual.
“Consumptive hypothyroidism usually requires aggressive thyroid replacement treatment, involving gradual LT4 dose increases until TSH normalizes, which should be measured more frequently than usual.”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [92]
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- Authors
- Jassam, N., Visser, T. J., Brisco, T., Bathia, D., McClean, P., & Barth, J. H.
- Affiliations
- Leeds Teaching Hospitals NHS Trust (GB)
- Erasmus MC (NL)
- ORCID
- Venue
- Annals of Clinical Biochemistry International Journal of Laboratory Medicine
- Publisher
- SAGE Publications
- Published
- 2011-03
- Volume
- 48
- Issue
- 2
- Pages
- 186-189
- ISSN
- 0004-5632 (ISSN-L)
- 1758-1001
- OpenAlex
- W2088456535
- Cited by
- 32
- References
- 17
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Clinical Biochemistry International Journal of Laboratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Vascular Malformations and Hemangiomas
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- type 3 iodothyronine deiodinase, thyroid hormone inactivation, neonatal hypothyroidism, infants, thyroid hormone replacement
- MeSH terms
- Female, Hemangioendothelioma, Humans, Hypothyroidism, Infant, Infant, Newborn, Male, Thyroid Function Tests, Young Adult
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