The Effect of Oxygen on the Response of Spontaneous Tumours in Mice to Radiotherapy
Abstract
The cure rate of spontaneous mammary adenocarcinomas in C3H mice irradiated daily while breathing air can be increased by changing to treatment twice a week or by allowing the mice to breathe pure oxygen at three atmospheres during treatment. Pure oxygen at atmospheric pressure is no more effective than air, probably due to depression of the respiratory rate by the oxygen. Oxygen at either pressure markedly increases systemic effects, as shown by early deaths. A mixture of 95 per cent oxygen and 5 per cent carbon dioxide at three atmospheres has about the same effect as pure oxygen at the same pressure on both cure rate and systemic effects. Only the gas mixture at atmospheric pressure gives the increased cure rate (because the respiratory stimulation and vasodilation resulting from the carbon dioxide carries more oxygen to the tumour) without increasing normal tissue reactions over those of air. It is, then, the technique of choice among those investigated.
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Carbogen improves blood flow and oxygenation more than pure oxygen because respiratory stimulation and vasodilation from carbon dioxide deliver more oxygen to the tumor.
“Studies have shown that carbogen improves blood flow and oxygenation more than pure oxygen because respiratory stimulation and vasodilation from carbon dioxide deliver more oxygen to the tumor.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [251]
Cites
Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158 · see citing works
Churchill‐Davidson, I., Sanger, C., & Thomlinson, R. H. (1957) · British Journal of Radiology · doi:10.1259/0007-1285-30-356-406 · Cited by 611 · see citing works
Factors Modifying the Effect of X-Irradiation on Regression of a Transplanted Lymphosarcoma
Hollcroft, J. W., LORENZ, E., & Matthews, M. L. V. (1952) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/12.4.751 · Cited by 42 · see citing works
The combination of oxygen and optimum fractionation in radiation therapy of adenocarcinoma.
Sault, L. A. D., Eyler, W. R., & Dobben, G. D. (1959) · PubMed · Cited by 22 · see citing works
The influence of the time factor on the dose-response curve.
SAULT, L. D. (1962) · PubMed · Cited by 9 · see citing works
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Modulation of the tumor vasculature and oxygenation to improve therapy
Siemann, D. W., & Horsman, M. R. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.006 · Cited by 169 · see citing works
Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
- Authors
- Du Sault, L. A.
- Venue
- The British Journal of Radiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1963-10
- Volume
- 36
- Issue
- 430
- Pages
- 749-754
- ISSN
- 0007-1285 (ISSN-L)
- 1748-880X
- OpenAlex
- W2154899058
- Cited by
- 64
- References
- 5
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Radiology (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- hyperbaric oxygen therapy, radiotherapy, tumor hypoxia, respiratory stimulation, vasodilation, normal tissue response, C3H mice
- MeSH terms
- Animals, Breast Neoplasms, Carbon Dioxide, Humans, Mammary Neoplasms, Experimental, Neoplasms, Oxygen, Oxygen Inhalation Therapy, Research, Mammary Neoplasms, Animal, Mice
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