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Cited by 608

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

A guide to ions and RNA structure

Open access
DRAPER, DAVID E.·2004·RNA

Abstract

RNA folding into stable tertiary structures is remarkably sensitive to the concentrations and types of cations present; an understanding of the physical basis of ion-RNA interactions is therefore a prerequisite for a quantitative accounting of RNA stability. This article summarizes the energetic factors that must be considered when ions interact with two different RNA environments. “Diffuse ions” accumulate near the RNA because of the RNA electrostatic field and remain largely hydrated. A “chelated” ion directly contacts a specific location on the RNA surface and is held in place by electrostatic forces. Energetic costs of ion chelation include displacement of some of the waters of hydration by the RNA surface and repulsion of diffuse ions. Methods are discussed for computing both the free energy of the set of diffuse ions associated with an RNA and the binding free energies of individual chelated ions. Such calculations quantitatively account for the effects of Mg 2+ on RNA stability where experimental data are available. An important conclusion is that diffuse ions are a major factor in the stabilization of RNA tertiary structures.

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Crossref · 10.1261/rna.5205404

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Metadata

Authors
DRAPER, D. E.
Venue
RNA
Published
2004-02-17
Volume
10
Issue
3
Pages
335-343
ISSN
  • 1355-8382 (ISSN-L)
  • 1469-9001
OpenAlex
W2132976721
Cited by
608
References
37
FWCI
8.09
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A guide to ions and RNA structure. https://app.cochat.ai/papers/10.1261/rna.5205404
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DRAPER, D. E. (2004). A guide to ions and RNA structure. RNA. https://doi.org/10.1261/rna.5205404

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.