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Cited by 77Immune Response and InflammationImmune responses and vaccinationsPlant-Microbe Interactions and Immunity

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Applications of lipopolysaccharide derived from Pantoea agglomerans (IP-PA1) for health care based on macrophage network theory

Kohchi, Chie, Inagawa, Hiroyuki, Nishizawa, Takashi, Yamaguchi, Takatoshi, Nagai, Shiro, Soma, Gen-Ichiro·2006·Journal of Bioscience and Bioengineering
DOI 10.1263/jbb.102.485
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Abstract

Innate immunity is a universal prophylactic system which all multi-cellular animals possess. Macrophages are the cells that play the central role in the innate immune system. In 1991, we discovered a substance in a water extract of wheat flour that activated macrophages after oral or intradermal administration. The active substance was lipopolysaccharide (LPS), which is derived from the cell walls of Pantoea agglomerans, gram-negative bacteria that grows symbiotically with wheat. We named the substance IP-PA1 (immuno potentiator from P. agglomerans, former name: LPSp). The IP-PA1 is considered to be useful in various fields such as health food (to prevent and improve metabolic syndromes), skincare products (to maintain healthy skin, to improve atopic dermatitis, and to resist aging), and as active ingredients in feeds for stockbreeding and aquaculture (to act as a defense against infection). In this manuscript, we discuss the significance of activation of macrophages through oral or intradermal administration, the discovery of IP-PA1 as a macrophage-activating substance, the chemical structure of IP-PA1, the use of IP-PA1 to improve various disorders, the mechanism of action, and the possibility of application of IP-PA1 to various fields.

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Metadata

Authors
Kohchi, C., Inagawa, H., Nishizawa, T., Yamaguchi, T., Nagai, S., & Soma, G.-I.
Affiliations
  • Tokyo University of Science (JP)
  • Tokushima Bunri University (JP)
  • Yaegaki BIO-Industry Inc. (Japan) (JP)
Corresponding author
Soma, Gen-Ichiro
ORCID
Venue
Journal of Bioscience and Bioengineering
Publisher
Elsevier BV
Published
2006-12
Volume
102
Issue
6
Pages
485-496
ISSN
  • 1347-4421 (ISSN-L)
  • 1389-1723
DOI
10.1263/jbb.102.485
OpenAlex
W2039856121
Cited by
77
References
70
Citations by year
2026: 2 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 6 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 7 · 2012: 3
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Bioscience and Bioengineering (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
Keywords
lipopolysaccharide, Pantoea agglomerans, macrophage activation, innate immunity, health foods, metabolic syndrome, skin care, atopic dermatitis, aquaculture feed
MeSH terms
Humans, Immunity, Innate, Lipopolysaccharides, Macrophage Activation, Macrophages, Male, Signal Transduction, Models, Immunological, Pantoea

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CoChat. (2026). Citation check: Applications of lipopolysaccharide derived from Pantoea agglomerans (IP-PA1) for health care based on macrophage network theory. https://app.cochat.ai/papers/10.1263/jbb.102.485
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Kohchi, C., Inagawa, H., Nishizawa, T., Yamaguchi, T., Nagai, S., & Soma, G.-I. (2006). Applications of lipopolysaccharide derived from Pantoea agglomerans (IP-PA1) for health care based on macrophage network theory. Journal of Bioscience and Bioengineering. https://doi.org/10.1263/jbb.102.485