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Cited by 17Sodium Intake and HealthParathyroid Disorders and TreatmentsBlood Pressure and Hypertension Studies

Effect of Salt Intervention on Serum Levels of Fibroblast Growth Factor 23 (FGF23) in Chinese Adults: An Intervention Study

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Hu, Jia-Wen, Wang, Yang, Chu, Chao, Mu, Jian-Jun·2018·Medical Science Monitor
DOI 10.12659/msm.906489PMC PMC5898259
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Abstract

BACKGROUND Fibroblast growth factor 23 (FGF23), a prominent regulator of phosphate and calcium metabolism, regulates sodium excretion in distal tubules through sodium-chloride cotransporter. This effect regulates blood pressure. Salt intake exerts effects on serum levels of FGF23 in mice. The aim of this study was to explore whether salt intervention affects serum concentrations of FGF23 in Chinese adults. MATERIAL AND METHODS We enrolled 44 participants from Lantian, a rural community of Shaanxi, China. All participants were maintained on a three-day normal diet, which was sequentially followed by a seven-day low-Na+ diet and seven-day high-Na+ diet. Serum FGF23 concentrations were assessed by ELISA. RESULTS Serum FGF23 concentrations elevated during low-salt diet compared with levels at baseline (66.20±44.21 pg/mL versus 86.77±53.74 pg/mL, p<0.05) and remarkably decreased when changed from low to high salt intake (86.77±53.74 pg/mL versus 49.26±42.67 pg/mL, p<0.001). Responses of FGF23 to salt intervention were more prominent in normotensive, older than 60 years, BMI <24 kg/m² and salt-resistant individuals. Furthermore, a significant inverse correlation was observed between 24-hour urinary sodium and serum concentrations of FGF23 after adjusting age, sex, BMI and hypertension status. CONCLUSIONS Dietary salt intervention significantly affects serum FGF23 in Chinese adults.

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  • The literature suggests that high sodium intake is associated with lower cFGF23 expression.

    “The literature suggests that high sodium intake is associated with lower cFGF23 expression [27, 29, 48, 62].”

    From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [27]

    The Results (Effect of dietary salt intervention on serum FGF23; page not provided) report lower serum FGF23 after a switch from low to high sodium intake. But the Methods (Laboratory measurements; page not provided) specify an assay for intact FGF23, not c-terminal FGF23 (cFGF23), and the study measured serum concentration rather than expression. (LLM, conf=0.87)

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Research works printed but not linked: 29

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Cited by

Sorted by citations

Authors
Hu, J.-W., Wang, Y., Chu, C., & Mu, J.-J.
Affiliations
  • Department of Cardiology, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shaanxi, China (mainland)
  • First Affiliated Hospital of Xi'an Jiaotong University (CN)
ORCID
Wang, Yang
Venue
Medical Science Monitor
Publisher
International Scientific Information, Inc.
Published
2018-04-02
Volume
24
Pages
1948-1954
ISSN
  • 1234-1010 (ISSN-L)
  • 1643-3750
DOI
10.12659/msm.906489
PMC
PMC5898259
OpenAlex
W2796362969
Cited by
17
References
0
Citations by year
2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 6 · 2019: 1 · 2018: 1 · 2012: 1
FWCI
1.65
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Medical Science Monitor (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (No. 81600327, 81600327, 81570381, 81370357)
  • Xi’an Jiaotong University (81600327)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
fibroblast growth factor 23, salt intake, sodium restriction, high-salt diet, sodium chloride cotransporter, sodium excretion, hypertension, Chinese adults
MeSH terms
Fibroblast Growth Factor-23, Adult, Age Factors, Blood Pressure, China, Diet, Female, Fibroblast Growth Factors, Humans, Hypertension, Male, Sodium Chloride, Sodium Chloride, Dietary, Asian People

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