The DOI matches its Crossref record; 95 of the 98 references it cites were found in a registry or an index.
Time scale of eutherian evolution estimated without assuming a constant rate of molecular evolution.
Open accessAbstract
Controversies over the molecular clock hypothesis were reviewed. Since it is evident that the molecular clock does not hold in an exact sense, accounting for evolution of the rate of molecular evolution is a prerequisite when estimating divergence times with molecular sequences. Recently proposed statistical methods that account for this rate variation are overviewed and one of these procedures is applied to the mitochondrial protein sequences and to the nuclear gene sequences from many mammalian species in order to estimate the time scale of eutherian evolution. This Bayesian method not only takes account of the variation of molecular evolutionary rate among lineages and among genes, but it also incorporates fossil evidence via constraints on node times. With denser taxonomic sampling and a more realistic model of molecular evolution, this Bayesian approach is expected to increase the accuracy of divergence time estimates.
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“A similar result was obtained for animals under various models of clock relaxation (22, 28) and for mitochondrial genomes of mammals (29).”
From The timing of eukaryotic evolution: Does a relaxed molecular clock reconcile proteins and fossils? (2004) · cites this paper as [29]
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Cited by
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Computational Molecular Evolution
Yang, Z. (2006) · doi:10.1093/acprof:oso/9780198567028.001.0001 · Cited by 1,152
The timing of eukaryotic evolution: Does a relaxed molecular clock reconcile proteins and fossils?
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Metadata
- Authors
- Hasegawa, M., Thorne, J. L., & Kishino, H.
- Affiliations
- The Graduate University for Advanced Studies, SOKENDAI (JP)
- North Carolina State University (US)
- The University of Tokyo (JP)
- Venue
- Genes & Genetic Systems
- Publisher
- Genetics Society of Japan
- Published
- 2003
- Volume
- 78
- Issue
- 4
- Pages
- 267-283
- ISSN
- 1341-7568 (ISSN-L)
- 1880-5779
- OpenAlex
- W2001967468
- Cited by
- 145
- References
- 98
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 21 · 2013: 3 · 2012: 7
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Genetic Systems (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Mitsubishi Foundation
- Japan Society for the Promotion of Science
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- divergence time estimation, molecular clock, rate variation, Bayesian phylogenetics, fossil calibration, molecular evolution rate
- MeSH terms
- Animals, Bayes Theorem, Fossils, Humans, Mathematics, Models, Biological, Models, Genetic, Phylogeny, Probability, Time Factors, Genetic Variation, Evolution, Molecular
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