CoChat
Sign Up
Cited by 29Mosquito-borne diseases and controlVirology and Viral DiseasesInfectious Encephalopathies and Encephalitis

The DOI matches its Crossref record; 280 of the 284 references it cites were found in a registry or an index.

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barre syndrome: a living systematic review

Open access
Counotte, Michel Jacques, Meili, Kaspar Walter, Taghavi, Katayoun, Calvet, Guilherme, Sejvar, James, Low, Nicola·2019·F1000Research
DOI 10.12688/f1000research.19918.1PMC PMC6852328
Open this paper in CoChat — free accountOpen PDF

Abstract

Background: The Zika virus (ZIKV) caused a large outbreak in the Americas leading to the declaration of a Public Health Emergency of International Concern in February 2016. A causal relation between infection and adverse congenital outcomes such as microcephaly was declared by the World Health Organization (WHO) informed by a systematic review structured according to a framework of ten dimensions of causality, based on the work of Bradford Hill. Subsequently, the evidence has continued to accumulate, which we incorporate in regular updates of the original work, rendering it a living systematic review. Methods: We present an update of our living systematic review on the causal relation between ZIKV infection and adverse congenital outcomes and between ZIKV and GBS for four dimensions of causality: strength of association, dose-response, specificity, and consistency. We assess the evidence published between January 18, 2017 and July 1, 2019. Results: We found that the strength of association between ZIKV infection and adverse outcomes from case-control studies differs according to whether exposure to ZIKV is assessed in the mother (OR 3.8, 95% CI: 1.7-8.7, I 2 =19.8%) or the foetus/infant (OR 37.4, 95% CI: 11.0-127.1, I 2 =0%). In cohort studies, the risk of congenital abnormalities was 3.5 times higher after ZIKV infection (95% CI: 0.9-13.5, I 2 =0%). The strength of association between ZIKV infection and GBS was higher in studies that enrolled controls from hospital (OR: 55.8, 95% CI: 17.2-181.7, I 2 =0%) than in studies that enrolled controls at random from the same community or household (OR: 2.0, 95% CI: 0.8-5.4, I 2 =74.6%). In case-control studies, selection of controls from hospitals could have biased results. Conclusions: The conclusions that ZIKV infection causes adverse congenital outcomes and GBS are reinforced with the evidence published between January 18, 2017 and July 1, 2019.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.12688/f1000research.19918.1

Cites

280 of 280 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Items 201–280 of 280

Flagged first, then by citations

4 of the 284 references couldn’t be matched to a known paper.

Research works printed but not linked: 8

  1. D Saulino, 2017, The first zika-related infant mortality in the United States: An autopsy case report., Laboratory Investigation., 97, 10A
  2. M De Fatima Viana Vasco Aragao, 2018, Congenital Zika Syndrome: Comparison of brain CT scan with postmortem histological sections from the same subjects., Neuroradiology., 60, 367-8
  3. M Cano, 2018, Zika virus infection in Hospital del Niño 'Dr José Renán Esquivel' (Panamá): Case Review since the introduction in Latin America., Pediátr Panamá., 47, 15-9
  4. A Collier, 2018, Maternal Immune Response to Zika Virus., Reproductive Sciences., 25, 163a-4a
  5. R Caixeta, 2018, Vertical transmission of zika virus and perinatal microcephaly., Int J Gynaecol Obstet., 143, 725, 10.1002/ijgo.12583 · DOI
  6. M Jones, 2018, Multidisciplinary approach to Guillain-Barre Syndrome and neurologic injuries after zika virus., J Spinal Cord Med., 41, 588
  7. A Ali, 2017, Zik-V outbreak and Guillain-Barre syndrome in Jamaica., Neurology., 88
  8. M Dourado, 2017, High Incidence of Guillain-Barre Syndrome after Zika Virus Infection in the State Rio Grande Do Norte, in Northeast Brazil., J Peripher Nerv Syst., 22, 275-6

Cited by

Sorted by citations

See all 29

Related

See all

Metadata

Authors
Counotte, M. J., Meili, K. W., Taghavi, K., Calvet, G., Sejvar, J., & Low, N.
Affiliations
  • University of Bern (CH)
  • Instituto Nacional de Infectologia Evandro Chagas (BR)
  • Centers for Disease Control and Prevention (US)
Corresponding author
  • Counotte, Michel Jacques
  • Low, Nicola
ORCID
Venue
F1000Research
Publisher
F1000 Research Ltd
Published
2019-08-14
Volume
8
Pages
1433
ISSN
2046-1402 (ISSN-L)
DOI
10.12688/f1000research.19918.1
PMC
PMC6852328
OpenAlex
W3033655606
Cited by
29
References
284
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 7 · 2019: 1
FWCI
0.61
Type
journal article
Language
en
Open access
Licence
Locations
  • F1000Research (publishedVersion, cc-by)
  • Americanae (AECID Library) (publishedVersion, other-oa)
  • Arca - Repositório Institucional da Fiocruz (publishedVersion, other-oa)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
  • Open Access CRIS of the University of Bern
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (320030_170069)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Keywords
Zika virus infection, congenital brain malformation, Guillain-Barré syndrome, microcephaly, causal inference, Bradford Hill criteria, associative strength, dose-response relationship, specificity, consistency, maternal infection, fetal infection, control selection bias

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review