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Cited by 15Wound Healing and TreatmentsPhytochemistry and biological activity of medicinal plantsBee Products Chemical Analysis

Effect of snail mucus on angiogenesis during wound healing

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Rosanto, Yosaphat Bayu, Hasan, Cahya Yustisia, Rahardjo, Rahardjo, Pangestiningsih, Tri Wahyu·2021·F1000Research
DOI 10.12688/f1000research.51297.2PMC PMC11190653
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Abstract

Background: Angiogenesis is the process through which new blood vessels are formed from existing ones. This process plays an important role in supplying the oxygen and nutrients needed for cellular metabolism and eliminating cell debris during wound healing. Snail mucus can bind to several factors that stimulate angiogenesis, including vascular endothelial growth factor, platelet-derived growth factor, and fibroblast growth factor. The aim of this study is to observe changes in angiogenesis during the healing of wounds topically applied with snail mucus. Methods: Punch biopsy was performed on the back of male Wistar rats to obtain four wounds, and different concentrations of snail mucus were applied to each of these wounds. The animals were sacrificed on days 2, 4, and 7 to observe the extent of angiogenesis during wound healing by microscopy. Results: Two-way ANOVA showed differences in number of blood vessels formed (p = 0.00) and day of observation (p = 0.00) between groups. Post hoc Tukey’s HSD test showed that 24% snail mucus treatment does not significantly affect wound healing (p = 0.488); by contrast, treatment with 48% and 96% snail mucus demonstrated significant effects on angiogenesis (p = 0.01). Spearman’s test showed interactive effects between snail mucus concentration and day of observation on the extent of angiogenesis (p = 0.001, R = 0.946). Conclusion: Topical application of snail mucus gel can increase angiogenesis during wound healing in Wistar rat skin.

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Cited by

Sorted by citations

Authors
Rosanto, Y. B., Hasan, C. Y., Rahardjo, R., & Pangestiningsih, T. W.
Affiliations
Universitas Gadjah Mada (ID)
Corresponding author
Hasan, Cahya Yustisia
ORCID
Venue
F1000Research
Publisher
F1000 Research Ltd
Published
2021-05-21
Volume
10
Pages
181
ISSN
2046-1402 (ISSN-L)
DOI
10.12688/f1000research.51297.2
PMC
PMC11190653
OpenAlex
W3134523492
Cited by
15
References
0
Citations by year
2026: 1 · 2025: 7 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1
FWCI
0.92
Type
journal article
Language
en
Open access
Licence
Locations
  • F1000Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Bee Products Chemical Analysis
Keywords
snail mucus, angiogenesis, wound healing, topical application, vascular endothelial growth factor, platelet-derived growth factor, fibroblast growth factor, skin wounds, growth factor binding

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