The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
The myofibroblast in wound healing and fibrosis: answered and unanswered questions
Open accessAbstract
The discovery of the myofibroblast has allowed definition of the cell responsible for wound contraction and for the development of fibrotic changes. This review summarizes the main features of the myofibroblast and the mechanisms of myofibroblast generation. Myofibroblasts originate from a variety of cells according to the organ and the type of lesion. The mechanisms of myofibroblast contraction, which appear clearly different to those of smooth muscle cell contraction, are described. Finally, we summarize the possible strategies in order to reduce myofibroblast activities and thus influence several pathologies, such as hypertrophic scars and organ fibrosis.
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Cites
Myofibroblasts and mechano-regulation of connective tissue remodelling
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Self-citationMechanisms of fibrosis: therapeutic translation for fibrotic disease
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Self-citationPresence of modified fibroblasts in granulation tissue and their possible role in wound contraction
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Distinct fibroblast lineages determine dermal architecture in skin development and repair
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Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity
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Valkenburg, K. C., de Groot, A. E., & Pienta, K. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0007-1 · Cited by 1,084
Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis
Xie, T., Wang, Y., Deng, N., Huang, G., Taghavifar, F., Geng, Y., Liu, N., Kulur, V., Yao, C., Chen, P., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.010 · Cited by 527
The role of myofibroblasts in wound healing
Hinz, B. (2016) · Current Research in Translational Medicine · doi:10.1016/j.retram.2016.09.003 · Cited by 328
Self-citationSuthahar, N., Meijers, W. C., Silljé, H. H. W., & de Boer, R. A. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0343-y · Cited by 307
Savin, I. A., Zenkova, M. A., & Sen’kova, A. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314959 · Cited by 279
Metadata
- Authors
- Bochaton-Piallat, M.-L., Gabbiani, G., & Hinz, B.
- Venue
- F1000Research
- Publisher
- F1000 Research Ltd
- Published
- 2016-04-26
- Volume
- 5
- Pages
- 752
- ISSN
- 2046-1402 (ISSN-L)
- OpenAlex
- W2342591146
- Cited by
- 293
- References
- 73
- FWCI
- 26.69
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
