The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Guidelines for performing Mendelian randomization investigations: update for summer 2023
Open accessAbstract
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.
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Cites
Bowden, J., Davey Smith, G., & Burgess, S. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv080 · Cited by 9,816
Self-citationBowden, J., Davey Smith, G., Haycock, P. C., & Burgess, S. (2016) · Genetic Epidemiology · doi:10.1002/gepi.21965 · Cited by 8,922
Self-citationVerbanck, M., Chen, C.-Y., Neale, B., & Do, R. (2018) · Nature Genetics · doi:10.1038/s41588-018-0099-7 · Cited by 8,591
The MR-Base platform supports systematic causal inference across the human phenome
Hemani, G., Zheng, J., Elsworth, B., Wade, K. H., Haberland, V., Baird, D., Laurin, C., Burgess, S., Bowden, J., Langdon, R., et al. (2018) · eLife · doi:10.7554/elife.34408 · Cited by 7,959
Self-citationMendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
Burgess, S., Butterworth, A., & Thompson, S. G. (2013) · Genetic Epidemiology · doi:10.1002/gepi.21758 · Cited by 6,050
Self-citationDavey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, B. K., Loh, P.-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., & Neale, B. M. (2015) · Nature Genetics · doi:10.1038/ng.3211 · Cited by 5,559
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Davey Smith, G., & Hemani, G. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu328 · Cited by 4,677
Self-citationMendelian randomization: Using genes as instruments for making causal inferences in epidemiology
Lawlor, D. A., Harbord, R. M., Sterne, J. A. C., Timpson, N., & Davey Smith, G. (2008) · Statistics in Medicine · doi:10.1002/sim.3034 · Cited by 4,618
Self-citationInterpreting findings from Mendelian randomization using the MR-Egger method.
Burgess, S., & Thompson, S. G. (2017) · European Journal of Epidemiology · doi:10.1007/s10654-017-0255-x · Cited by 4,571
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Cited by
Social-Science Genomics: Progress, Challenges, and Future Directions
Benjamin, D., Cesarini, D., Turley, P., & Young, A. S. (2024) · doi:10.3386/w32404 · Cited by 20
He, Y., Chen, C.-L., He, J., & Liu, S.-D. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i44.5872 · Cited by 10
Wang, Z., Wang, Z., Ji, X., Zhao, L., Zheng, K., Yu, W., Zhang, H., Chang, H., & Liu, F. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08301-z
Metadata
- Authors
- Burgess, S., Davey Smith, G., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Kutalik, Z., Holmes, M. V., Minelli, C., Morrison, J. V., Pan, W., Relton, C. L., & Theodoratou, E.
- Venue
- Wellcome Open Research
- Publisher
- F1000 Research Ltd
- Published
- 2023-08-04
- Volume
- 4
- Pages
- 186
- ISSN
- 2398-502X (ISSN-L)
- OpenAlex
- W4385577954
- Cited by
- 721
- References
- 166
- FWCI
- 107.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Burgess, S., Davey Smith, G., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Kutalik, Z., Holmes, M. V., Minelli, C., Morrison, J. V., Pan, W., Relton, C. L., & Theodoratou, E. (2023). Guidelines for performing Mendelian randomization investigations: update for summer 2023. Wellcome Open Research. https://doi.org/10.12688/wellcomeopenres.15555.3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
