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Hypocholesterolemic Effect of Chitosan in Adult Males
Abstract
The present study is the first to report the hypocholesterolemic effect of chitosan on humans. When 3–6 g/day of chitosan was given in the diet to 8 healthy males, total serum cholesterol significantly decreased, and when the ingestion was stopped, the value increased to the level before ingestion. Serum HDL-cholesterol was increased significantly by the ingestion of chitosan. The excreted amounts of primary bile acids, cholic acid and chenodeoxycholic acid, into the feces was significantly increased by the ingestion of chitosan, and the amount of cholic acid excretion decreased significantly after the ingestion was stopped. These facts suggest that chitosan combined bile acids in the digestive tract, and that the combined product was excreted into the feces. This, in turn, deceased the resorption of bile acids, so that the cholesterol poool in the body was decreased and the level of serum chrolesterol consequently decreased.
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Citations
Cited by
Chitosan: an update on potential biomedical and pharmaceutical applications.
Cheung, R., Ng, T., Wong, J., & Chan, W. (2015) · Marine Drugs · doi:10.3390/md13085156 · Cited by 1,297
Roy, K., Mao, H.-Q., Huang, S. K., & Leong, K. W. (1999) · Nature Medicine · doi:10.1038/7385 · Cited by 1,106
Enzymatic production and biological activities of chitosan oligosaccharides (COS): A review
KIM, S., & RAJAPAKSE, N. (2005) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2005.08.012 · Cited by 844
Chitosan Modification and Pharmaceutical/Biomedical Applications
Zhang, J., Xia, W., Liu, P., Cheng, Q., Tahi, T., Gu, W., & Li, B. (2010) · Marine Drugs · doi:10.3390/md8071962 · Cited by 526
Human enzymatic activities related to the therapeutic administration of chitin derivatives
Muzzarelli, R. A. A. (1997) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000584 · Cited by 516
Metadata
- Authors
- Maezaki, Y., Tsuji, K., Nakagawa, Y., Kawai, Y., Akimoto, M., Tsugita, T., Takekawa, W., Terada, A., Hara, H., & Mitsuoka, T.
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 1993-01
- Volume
- 57
- Issue
- 9
- Pages
- 1439-1444
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2025970938
- Cited by
- 239
- References
- 0
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maezaki, Y., Tsuji, K., Nakagawa, Y., Kawai, Y., Akimoto, M., Tsugita, T., Takekawa, W., Terada, A., Hara, H., & Mitsuoka, T. (1993). Hypocholesterolemic Effect of Chitosan in Adult Males. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1271/bbb.57.1439
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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