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Chitosan Modification and Pharmaceutical/Biomedical Applications
Open accessAbstract
Chitosan has received much attention as a functional biopolymer for diverse applications, especially in pharmaceutics and medicine. Our recent efforts focused on the chemical and biological modification of chitosan in order to increase its solubility in aqueous solutions and absorbability in the in vivo system, thus for a better use of chitosan. This review summarizes chitosan modification and its pharmaceutical/biomedical applications based on our achievements as well as the domestic and overseas developments: (1) enzymatic preparation of low molecular weight chitosans/chitooligosaccharides with their hypocholesterolemic and immuno-modulating effects; (2) the effects of chitin, chitosan and their derivatives on blood hemostasis; and (3) synthesis of a non-toxic ion ligand—D-Glucosaminic acid from Oxidation of D-Glucosamine for cancer and diabetes therapy.
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Chitosan Chemistry: Relevance to the Biomedical Sciences
Muzzarelli, R. A. A., & Muzzarelli, C. (2005) · Advances in Polymer Science · doi:10.1007/b136820 · Cited by 555
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Naveed, M., Phil, L., Sohail, M., Hasnat, M., Baig, M. M. F. A., Ihsan, A. U., Shumzaid, M., Kakar, M. U., Mehmood Khan, T., Akabar, M., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.01.192 · Cited by 508
Bio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review
Ryu, J. H., Hong, S., & Lee, H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.08.043 · Cited by 428
Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage
Gaharwar, A. K., Avery, R. K., Assmann, A., Paul, A., McKinley, G. H., Khademhosseini, A., & Olsen, B. D. (2014) · ACS Nano · doi:10.1021/nn503719n · Cited by 403
Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
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Metadata
- Authors
- Zhang, J., Xia, W., Liu, P., Cheng, Q., Tahi, T., Gu, W., & Li, B.
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2010-06-25
- Volume
- 8
- Issue
- 7
- Pages
- 1962-1987
- ISSN
- 1660-3397 (ISSN-L)
- OpenAlex
- W2011472105
- Cited by
- 526
- References
- 1
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, J., Xia, W., Liu, P., Cheng, Q., Tahi, T., Gu, W., & Li, B. (2010). Chitosan Modification and Pharmaceutical/Biomedical Applications. Marine Drugs. https://doi.org/10.3390/md8071962
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