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Polysaccharides from Agaricus blazei Stimulate Lymphocyte T-Cell Subsets in Mice.
Open accessAbstract
Subset analysis of splenic lymphocytes using flow cytometry showed that the percentages of Thy1.2-(pan T-cells), L3T4-(CD4, helper T-cells), and Lyt2-(CD8, cytotoxic T-cells) positive cell populations were significantly increased in mice orally administered a hot water-soluble fraction from Agaricus blazei as compared with mice treated only with saline. 13C-NMR data indicates that the main component in the active polysaccharide is the complex of alpha-1,6- and alpha-1,4-glucan, which had already been shown to have anti-tumor activity against Sarcoma 180. It seems that the polysaccharide from Agaricus blazei may be an effective prophylactic, protecting humans against cancer by stimulating lymphocytes such as cytotoxic T-cells.
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Cited by
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Zhang, L., Li, X., Xu, X., & Zeng, F. (2005) · Carbohydrate Research · doi:10.1016/j.carres.2005.02.032 · Cited by 320
Metadata
- Authors
- MIZUNO, M., MORIMOTO, M., MINATO, K.-I., & TSUCHIDA, H.
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 1998
- Volume
- 62
- Issue
- 3
- Pages
- 434-437
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2093284450
- Cited by
- 202
- References
- 0
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Polysaccharides from Agaricus blazei Stimulate Lymphocyte T-Cell Subsets in Mice. https://app.cochat.ai/papers/10.1271/bbb.62.434
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- MIZUNO, M., MORIMOTO, M., MINATO, K.-I., & TSUCHIDA, H. (1998). Polysaccharides from Agaricus blazei Stimulate Lymphocyte T-Cell Subsets in Mice. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1271/bbb.62.434
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