The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Natural Antioxidant, Chlorogenic Acid, Protects Against DNA Breakage Caused by Monochloramine
Abstract
Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, from I-->form II-->form III, induced by 3 mM monochloramine with a half inhibition of 67.4 microM. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.
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“Shibata et al. (1999) treated plasmid pUC18 DNA with 3 mM monochloramine, which induced double strand DNA breaks.”
From Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting (2020) · cites this paper as Shibata et al. 1999
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Metadata
- Authors
- SHIBATA, H., SAKAMOTO, Y., OKA, M., & KONO, Y.
- Affiliations
- Shimane University (JP)
- ORCID
- SAKAMOTO, Yuji
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01
- Volume
- 63
- Issue
- 7
- Pages
- 1295-1297
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2083491853
- Cited by
- 91
- References
- 24
- Citations by year
- 2026: 1 · 2024: 5 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 2 · 2012: 3
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- chlorogenic acid, monochloramine, DNA strand breaks, genotoxicity, gastric mucosa, antioxidants, DNA damage protection, pH-dependent reaction
- MeSH terms
- Ammonium Chloride, Antioxidants, Chloramines, Chlorogenic Acid, DNA Damage, DNA, Bacterial, Plasmids, Spectrophotometry, Ultraviolet, Helicobacter pylori
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