The DOI matches its Crossref record.
Antiproliferative Activity of Flavonoids on Several Cancer Cell Lines
Open accessAbstract
Twenty-seven Citrus flavonoids were examined for their antiproliferative activities against several tumor and normal human cell lines. As a result, 7 flavonoids were judged to be active against the tumor cell lines, while they had weak antiproliferative activity against the normal human cell lines. The rank order of potency was luteolin, natsudaidain, quercetin, tangeretin, eriodictyol, nobiletin, and 3,3',4',5,6,7,8-heptamethoxyflavone. The structure-activity relationship established from comparison among these flavones and flavanones showed that the ortho-catechol moiety in ring B and a C2-C3 double bond were important for the antiproliferative activity. As to polymethoxylated flavones, C-3 hydroxyl and C-8 methoxyl groups were essential for high activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Benavente-García, O., & Castillo, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8006568 · Cited by 1,158
Quantitation of Flavonoid Constituents in Citrus Fruits
Kawaii, S., Tomono, Y., Katase, E., Ogawa, K., & Yano, M. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990153+ · Cited by 337
Self-citation
Metadata
- Authors
- KAWAII, S., TOMONO, Y., KATASE, E., OGAWA, K., & YANO, M.
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01
- Volume
- 63
- Issue
- 5
- Pages
- 896-899
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2025071869
- Cited by
- 334
- References
- 0
- FWCI
- 14.27
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Antiproliferative Activity of Flavonoids on Several Cancer Cell Lines. https://app.cochat.ai/papers/10.1271/bbb.63.896
- The paper
- KAWAII, S., TOMONO, Y., KATASE, E., OGAWA, K., & YANO, M. (1999). Antiproliferative Activity of Flavonoids on Several Cancer Cell Lines. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1271/bbb.63.896
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
