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Antiproliferative Activity of Flavonoids on Several Cancer Cell Lines
Open accessAbstract
Twenty-seven Citrus flavonoids were examined for their antiproliferative activities against several tumor and normal human cell lines. As a result, 7 flavonoids were judged to be active against the tumor cell lines, while they had weak antiproliferative activity against the normal human cell lines. The rank order of potency was luteolin, natsudaidain, quercetin, tangeretin, eriodictyol, nobiletin, and 3,3',4',5,6,7,8-heptamethoxyflavone. The structure-activity relationship established from comparison among these flavones and flavanones showed that the ortho-catechol moiety in ring B and a C2-C3 double bond were important for the antiproliferative activity. As to polymethoxylated flavones, C-3 hydroxyl and C-8 methoxyl groups were essential for high activity.
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Citations
Cited by
The biochemistry and medical significance of the flavonoids
Havsteen, B. H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00298-x · Cited by 2,672
Benavente-García, O., & Castillo, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8006568 · Cited by 1,158
Cytotoxicity of dietary flavonoids on different human cancer types
Sak, K. (2014) · Pharmacognosy Reviews · doi:10.4103/0973-7847.134247 · Cited by 461
Antiproliferative Activities of Citrus Flavonoids against Six Human Cancer Cell Lines
Manthey, J. A., & Guthrie, N. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020121d · Cited by 362
Quantitation of Flavonoid Constituents in Citrus Fruits
Kawaii, S., Tomono, Y., Katase, E., Ogawa, K., & Yano, M. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990153+ · Cited by 337
Self-citationSingh, B. N., Singh, B. R., Singh, R. L., Prakash, D., Singh, D. P., Sarma, B. K., Upadhyay, G., & Singh, H. B. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.02.004 · Cited by 268
Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones
Li, S., Pan, M.-H., Lo, C.-Y., Tan, D., Wang, Y., Shahidi, F., & Ho, C.-T. (2009) · Journal of Functional Foods · doi:10.1016/j.jff.2008.09.003 · Cited by 267
Metadata
- Authors
- KAWAII, S., TOMONO, Y., KATASE, E., OGAWA, K., & YANO, M.
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01
- Volume
- 63
- Issue
- 5
- Pages
- 896-899
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2025071869
- Cited by
- 334
- References
- 0
- FWCI
- 14.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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