The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cytotoxicity of dietary flavonoids on different human cancer types
Open accessAbstract
Flavonoids are ubiquitous in nature. They are also in food, providing an essential link between diet and prevention of chronic diseases including cancer. Anticancer effects of these polyphenols depend on several factors: Their chemical structure and concentration, and also on the type of cancer. Malignant cells from different tissues reveal somewhat different sensitivity toward flavonoids and, therefore, the preferences of the most common dietary flavonoids to various human cancer types are analyzed in this review. While luteolin and kaempferol can be considered as promising candidate agents for treatment of gastric and ovarian cancers, respectively, apigenin, chrysin, and luteolin have good perspectives as potent antitumor agents for cervical cancer; cells from main sites of flavonoid metabolism (colon and liver) reveal rather large fluctuations in anticancer activity probably due to exposure to various metabolites with different activities. Anticancer effect of flavonoids toward blood cancer cells depend on their myeloid, lymphoid, or erythroid origin; cytotoxic effects of flavonoids on breast and prostate cancer cells are highly related to the expression of hormone receptors. Different flavonoids are often preferentially present in certain food items, and knowledge about the malignant tissue-specific anticancer effects of flavonoids could be purposely applied both in chemoprevention as well as in cancer treatment.
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“[24,25,30,32,49,68] These polyphenolic compounds can interact with xenobiotics metabolizing enzymes, inhibit several kinases involved in signal transduction, interact with estrogen type II binding sites, and alter gene expression patterns.[61,69,70,71] Normal cell growth is maintained by the balance between cell proli…”
BackgroundInfluentialStructural Aspects of Flavonoids as Inhibitors of Human Butyrylcholinesterase
Katalinić, M., Rusak, G., Domaćinović Barović, J., Šinko, G., Jelić, D., Antolović, R., & Kovarik, Z. (2010) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2009.09.041 · Cited by 206
Cytotoxic Constituents of Baccharis gaudichaudiana
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Tavsan, Z., & Kayali, H. A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109004 · Cited by 190
Jomová, K., Hudecova, L., Lauro, P., Simunkova, M., Alwasel, S. H., Alhazza, I. M., & Valko, M. (2019) · Molecules · doi:10.3390/molecules24234335 · Cited by 172
Zhu, J., Wang, H., Chen, F., Fu, J., Xu, Y., Hou, Y., Kou, H. H., Zhai, C., Nelson, M. B., Zhang, Q., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.010 · Cited by 162
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Metadata
- Authors
- Sak, K.
- Venue
- Pharmacognosy Reviews
- Publisher
- Manuscript Technomedia LLP
- Published
- 2014
- Volume
- 8
- Issue
- 16
- Pages
- 122
- ISSN
- 0973-6581 (ISSN-L)
- 0973-7847
- OpenAlex
- W2146984617
- Cited by
- 461
- References
- 3
- FWCI
- 34.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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