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Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid
Abstract
Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1). Luteolin, amentoflavone, luteolin 7-O-glucoside, and daidzein were the strongest inhibitors among the compounds tested. Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus. Luteolin also inhibited alpha-amylase effectively although it was less potent than acarbose. The clinical value of luteolin needs to be further evaluated.
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Cited by
Ali, H., Houghton, P. J., & Soumyanath, A. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.04.004 · Cited by 773
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Campos-Vega, R., Loarca-Piña, G., & Oomah, B. D. (2010) · Food Research International · doi:10.1016/j.foodres.2009.09.004 · Cited by 530
Proença, C., Freitas, M., Ribeiro, D., Oliveira, E. F. T., Sousa, J. L. C., Tomé, S. M., Ramos, M. J., Silva, A. M. S., Fernandes, P. A., & Fernandes, E. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2017.1368503 · Cited by 432
Subramanian, R., Asmawi, M. Z., & Sadikun, A. (2008) · Acta Biochimica Polonica · doi:10.18388/abp.2008_3087 · Cited by 363
Schäfer, A., & Högger, P. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.10.011 · Cited by 136
Metadata
- Authors
- KIM, J.-S., KWON, C.-S., & SON, K. H.
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 64
- Issue
- 11
- Pages
- 2458-2461
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2020411326
- Cited by
- 667
- References
- 0
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- KIM, J.-S., KWON, C.-S., & SON, K. H. (2000). Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1271/bbb.64.2458
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