The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
Open accessAbstract
Sphingolipids have important roles in membrane and lipoprotein structure and in cell regulation as second messengers for growth factors, differentiation factors, cytokines, and a growing list of agonists. Bioactive sphingolipids are formed both by the turnover of complex sphingolipids and as intermediates of sphingolipid biosynthesis. Usually, the amounts are highly regulated; however, by inhibiting ceramide synthase, fumonisins block the biosynthesis of complex sphingolipids and cause sphinganine (and sometimes sphingosine) to accumulate. Where the mechanism has been studied most thoroughly, the accumulation of sphingoid bases is a primary cause of the toxicity of fumonisin B (FB). Nonetheless, the full effects of fumonisins probably involve many biochemical events. The elevations in sphingoid bases also affect the amounts of other lipids, including the 1-phosphates and N-acetyl derivatives of sphinganine. Furthermore, the aminopentol backbone of FB1 (AP1) is both an inhibitor and a substrate for ceramide synthase, and the resultant N-palmitoyl-AP1 (PAP1) is an even more potent inhibitor of ceramide synthase (presumably as a product analog). PAP1 is 10 times more toxic than FB1 or AP1 for HT-29 cells in culture, and hence may play a role in the toxicity of nixtamalized fumonisins. All these processes--the effects of fumonisins on sphingolipid metabolism, the pathways altered by perturbation of sphingolipid metabolism, and the complex cellular behaviors regulated by sphingolipids--must be borne in mind when evaluating the pathologic effects of fumonisins.
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Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T., & Merrill, A. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98712-0 · Cited by 1,113
Self-citationSphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
Olivera, A., & Spiegel, S. (1993) · Nature · doi:10.1038/365557a0 · Cited by 889
Bose, R., Verheij, M., Haimovitz-Friedman, A., Scotto, K., Fuks, Z., & Kolesnick, R. (1995) · Cell · doi:10.1016/0092-8674(95)90429-8 · Cited by 826
REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS
Kolesnick, R. N., & Krönke, M. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.643 · Cited by 803
Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology
Merrill, A. H., Schmelz, E.-M., Dillehay, D. L., Spiegel, S., Shayman, J. A., Schroeder, J. J., Riley, R. T., Voss, K. A., & Wang, E. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.8029 · Cited by 643
Self-citationCeramide: an intracellular signal for apoptosis
Hannun, Y. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)88961-6 · Cited by 595
Sphingolipids in Food and the Emerging Importance of Sphingolipids to Nutrition
Vesper, H., Schmelz, E.-M., Nikolova-Karakashian, M. N., Dillehay, D. L., Lynch, D. V., & Merrill, A. H. (1999) · The Journal of Nutrition · doi:10.1093/jn/129.7.1239 · Cited by 582
Self-citationRole for Ceramide in Cell Cycle Arrest
Jayadev, S., Liu, B., Bielawska, A. E., Lee, J. Y., Nazaire, F., Pushkareva, M. Y., Obeid, L. M., & Hannun, Y. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2047 · Cited by 486
Functional Role of Glycosphingolipids in Cell Recognition and Signaling
Hakomori, S.-I., & Igarashi, Y. (1995) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124992 · Cited by 395
Merrill, A. H., van Echten, G., Wang, E., & Sandhoff, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74249-5 · Cited by 371
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Cited by
Bennett, J. W., & Klich, M. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.497-516.2003 · Cited by 3,127
Mycotoxins and human disease: a largely ignored global health issue
Wild, C. P., & Gong, Y. Y. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp264 · Cited by 981
The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind
Hannun, Y. A., & Obeid, L. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200008200 · Cited by 907
Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
Merrill, A. H. (2011) · Chemical Reviews · doi:10.1021/cr2002917 · Cited by 785
Self-citationMerrill Jr., A. H., Sullards, M. C., Allegood, J. C., Kelly, S., & Wang, E. (2005) · Methods · doi:10.1016/j.ymeth.2005.01.009 · Cited by 594
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Metadata
- Authors
- Merrill, A. H., Sullards, M. C., Wang, E., Voss, K. A., & Riley, R. T.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-05
- Volume
- 109
- Issue
- suppl 2
- Pages
- 283-289
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2069028107
- Cited by
- 381
- References
- 40
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- gold
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