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Cited by 560

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Effect of Early Life Exposure to Air Pollution on Development of Childhood Asthma

Open access
Clark, Nina Annika, Demers, Paul A., Karr, Catherine J., Koehoorn, Mieke, Lencar, Cornel, Tamburic, Lillian, Brauer, Michael·2010·Environmental Health Perspectives

Abstract

Abstract Background There is increasing recognition of the importance of early environmental exposures in the development of childhood asthma. Outdoor air pollution is a recognized asthma trigger, but it is unclear whether exposure influences incident disease. We investigated the effect of exposure to ambient air pollution in utero and during the first year of life on risk of subsequent asthma diagnosis in a population-based nested case–control study. Methods We assessed all children born in southwestern British Columbia in 1999 and 2000 (n = 37,401) for incidence of asthma diagnosis up to 3–4 years of age using outpatient and hospitalization records. Asthma cases were age- and sex-matched to five randomly chosen controls from the eligible cohort. We estimated each individual’s exposure to ambient air pollution for the gestational period and first year of life using high-resolution pollution surfaces derived from regulatory monitoring data as well as land use regression models adjusted for temporal variation. We used logistic regression analyses to estimate effects of carbon monoxide, nitric oxide, nitrogen dioxide, particulate matter ≤ 10 μm and ≤ 2.5 μm in aerodynamic diameter (PM10 and PM2.5), ozone, sulfur dioxide, black carbon, woodsmoke, and proximity to roads and point sources on asthma diagnosis. Results A total of 3,482 children (9%) were classified as asthma cases. We observed a statistically significantly increased risk of asthma diagnosis with increased early life exposure to CO, NO, NO2, PM10, SO2, and black carbon and proximity to point sources. Traffic-related pollutants were associated with the highest risks: adjusted odds ratio = 1.08 (95% confidence interval, 1.04–1.12) for a 10-μg/m3 increase of NO, 1.12 (1.07–1.17) for a 10-μg/m3 increase in NO2, and 1.10 (1.06–1.13) for a 100-μg/m3 increase in CO. These data support the hypothesis that early childhood exposure to air pollutants plays a role in development of asthma.

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Metadata

Authors
Clark, N. A., Demers, P. A., Karr, C. J., Koehoorn, M., Lencar, C., Tamburic, L., & Brauer, M.
Venue
Environmental Health Perspectives
Published
2010-02
Volume
118
Issue
2
Pages
284-290
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
OpenAlex
W2015737793
Cited by
560
References
48
FWCI
19.24
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Effect of Early Life Exposure to Air Pollution on Development of Childhood Asthma. https://app.cochat.ai/papers/10.1289/ehp.0900916
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Clark, N. A., Demers, P. A., Karr, C. J., Koehoorn, M., Lencar, C., Tamburic, L., & Brauer, M. (2010). Effect of Early Life Exposure to Air Pollution on Development of Childhood Asthma. Environmental Health Perspectives. https://doi.org/10.1289/ehp.0900916

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