The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
In utero pesticide exposure, maternal paraoxonase activity, and head circumference.
Open accessAbstract
Although the use of pesticides in inner-city homes of the United States is of considerable magnitude, little is known about the potentially adverse health effects of such exposure. Recent animal data suggest that exposure to pesticides during pregnancy and early life may impair growth and neurodevelopment in the offspring. To investigate the relationship among prenatal pesticide exposure, paraoxonase (PON1) polymorphisms and enzyme activity, and infant growth and neurodevelopment, we are conducting a prospective, multiethnic cohort study of mothers and infants delivered at Mount Sinai Hospital in New York City. In this report we evaluate the effects of pesticide exposure on birth weight, length, head circumference, and gestational age among 404 births between May 1998 and May 2002. Pesticide exposure was assessed by a prenatal questionnaire administered to the mothers during the early third trimester as well as by analysis of maternal urinary pentachlorophenol levels and maternal metabolites of chlorpyrifos and pyrethroids. Neither the questionnaire data nor the pesticide metabolite levels were associated with any of the fetal growth indices or gestational age. However, when the level of maternal PON1 activity was taken into account, maternal levels of chlorpyrifos above the limit of detection coupled with low maternal PON1 activity were associated with a significant but small reduction in head circumference. In addition, maternal PON1 levels alone, but not PON1 genetic polymorphisms, were associated with reduced head size. Because small head size has been found to be predictive of subsequent cognitive ability, these data suggest that chlorpyrifos may have a detrimental effect on fetal neurodevelopment among mothers who exhibit low PON1 activity.
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Cites
Castellanos, F. X. (2002) · JAMA · doi:10.1001/jama.288.14.1740 · Cited by 1,646
Intellectual impairment in children exposed to polychlorinated biphenyls in utero
Jacobson, J. L., & Jacobson, S. W. (1996) · New England Journal of Medicine · doi:10.1056/nejm199609123351104 · Cited by 1,132
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
Shih, D. M., Gu, L., Xia, Y.-R., Navab, M., Li, W.-F., Hama, S., Castellani, L. W., Furlong, C. E., Costa, L. G., Fogelman, A. M., et al. (1998) · Nature · doi:10.1038/28406 · Cited by 1,078
Exposures of children to organophosphate pesticides and their potential adverse health effects.
Eskenazi, B., Bradman, A., & Castorina, R. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s3409 · Cited by 680
Low-Level Lead Exposure, Intelligence and Academic Achievement: A Long-term Follow-up Study
Bellinger, D. C., Stiles, K. M., & Needleman, H. L. (1992) · Pediatrics · doi:10.1542/peds.90.6.855 · Cited by 676
Aviram, M., Hardak, E., Vaya, J., Mahmood, S., Milo, S., Hoffman, A., Billicke, S., Draganov, D., & Rosenblat, M. (2000) · Circulation · doi:10.1161/01.cir.101.21.2510 · Cited by 460
Chlorpyrifos: Pharmacokinetics in human volunteers
Nolan, R. J., Rick, D. L., Freshour, N. L., & Saunders, J. H. (1984) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(84)90046-2 · Cited by 450
Effects of 5′ Regulatory-Region Polymorphisms on Paraoxonase-Gene (PON1) Expression
Brophy, V. H., Jampsa, R. L., Clendenning, J. B., McKinstry, L. A., Jarvik, G. P., & Furlong, C. E. (2001) · The American Journal of Human Genetics · doi:10.1086/320600 · Cited by 368
Pesticides and inner-city children: exposures, risks, and prevention.
Landrigan, P. J., Claudio, L., Markowitz, S. B., Berkowitz, G. S., Brenner, B. L., Romero, H., Wetmur, J. G., Matte, T. D., Gore, A. C., Godbold, J. H., et al. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s3431 · Cited by 336
Self-citationDevelopmental cholinotoxicants: nicotine and chlorpyrifos
Slotkin, T. A. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s171 · Cited by 292
Cited by
Developmental neurotoxicity of industrial chemicals
Grandjean, P., & Landrigan, P. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69665-7 · Cited by 1,984
Rauh, V. A., Garfinkel, R., Perera, F. P., Andrews, H. F., Hoepner, L., Barr, D. B., Whitehead, R., Tang, D., & Whyatt, R. W. (2006) · Pediatrics · doi:10.1542/peds.2006-0338 · Cited by 734
Prenatal Phenol and Phthalate Exposures and Birth Outcomes
Wolff, M. S., Engel, S. M., Berkowitz, G. S., Ye, X., Silva, M. J., Zhu, C., Wetmur, J., & Calafat, A. M. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11007 · Cited by 580
Self-citationRauh, V., Arunajadai, S., Horton, M., Perera, F., Hoepner, L., Barr, D. B., & Whyatt, R. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1003160 · Cited by 524
“Few human studies have focused on possible mechanisms underlying neurodevelopmental deficits associated with OP exposure, but there is evidence that certain genetic polymorphisms can affect CPF metabolism (e.g., Berkowitz et al. 2004).”
BackgroundBrain anomalies in children exposed prenatally to a common organophosphate pesticide
Rauh, V. A., Perera, F. P., Horton, M. K., Whyatt, R. M., Bansal, R., Hao, X., Liu, J., Barr, D. B., Slotkin, T. A., & Peterson, B. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203396109 · Cited by 470
Metadata
- Authors
- Berkowitz, G. S., Wetmur, J. G., Birman-Deych, E., Obel, J., Lapinski, R. H., Godbold, J. H., Holzman, I. R., & Wolff, M. S.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-03
- Volume
- 112
- Issue
- 3
- Pages
- 388-391
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2004180568
- Cited by
- 340
- References
- 32
- FWCI
- 26.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Berkowitz, G. S., Wetmur, J. G., Birman-Deych, E., Obel, J., Lapinski, R. H., Godbold, J. H., Holzman, I. R., & Wolff, M. S. (2004). In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environmental Health Perspectives. https://doi.org/10.1289/ehp.6414
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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