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Cited by 734Pesticide Exposure and ToxicityEffects and risks of endocrine disrupting chemicalsToxic Organic Pollutants Impact

Impact of Prenatal Chlorpyrifos Exposure on Neurodevelopment in the First 3 Years of Life Among Inner-City Children

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Rauh, Virginia A., Garfinkel, Robin, Perera, Frederica P., Andrews, Howard F., Hoepner, Lori, Barr, Dana B., Whitehead, Ralph, Tang, Deliang +1 more·2006·Pediatrics
DOI 10.1542/peds.2006-0338PMC PMC3390915
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Abstract

OBJECTIVE. The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children. METHODS. As part of an ongoing prospective cohort study in an inner-city minority population, neurotoxicant effects of prenatal exposure to chlorpyrifos were evaluated in 254 children through the first 3 years of life. This report examined cognitive and motor development at 12, 24, and 36 months (measured with the Bayley Scales of Infant Development II) and child behavior at 36 months (measured with the Child Behavior Checklist) as a function of chlorpyrifos levels in umbilical cord plasma. RESULTS. Highly exposed children (chlorpyrifos levels of >6.17 pg/g plasma) scored, on average, 6.5 points lower on the Bayley Psychomotor Development Index and 3.3 points lower on the Bayley Mental Development Index at 3 years of age compared with those with lower levels of exposure. Children exposed to higher, compared with lower, chlorpyrifos levels were also significantly more likely to experience Psychomotor Development Index and Mental Development Index delays, attention problems, attention-deficit/hyperactivity disorder problems, and pervasive developmental disorder problems at 3 years of age. CONCLUSIONS. The adjusted mean 36-month Psychomotor Development Index and Mental Development Index scores of the highly and lower exposed groups differed by only 7.1 and 3.0 points, respectively, but the proportion of delayed children in the high-exposure group, compared with the low-exposure group, was 5 times greater for the Psychomotor Development Index and 2.4 times greater for the Mental Development Index, increasing the number of children possibly needing early intervention services.

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  • CPF has been linked to ADHD and other developmental neural disorders in children.

    “CPF has been linked to ADHD and other developmental neural disorders in children, prompting the EPA to impose a ban on residential use in 2001 (22, 106, 107).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [106]

    The Results (Table 8) link prenatal chlorpyrifos exposure to attention, ADHD, and pervasive developmental disorder problems at 36 months. The Discussion cautions that these are checklist-based problems in a small group, not established clinical diagnoses; it says the effect on the onset of clinically diagnosed ADHD is unclear. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Authors
Rauh, V. A., Garfinkel, R., Perera, F. P., Andrews, H. F., Hoepner, L., Barr, D. B., Whitehead, R., Tang, D., & Whyatt, R. W.
Affiliations
  • Columbia University (US)
  • Centers for Disease Control and Prevention (US)
  • Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, New York, New York
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2006-12-01
Volume
118
Issue
6
Pages
e1845-e1859
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2006-0338
PMC
PMC3390915
OpenAlex
W2143786272
Cited by
734
References
2
Citations by year
2026: 20 · 2025: 25 · 2024: 23 · 2023: 30 · 2022: 36 · 2021: 39 · 2020: 51 · 2019: 40 · 2018: 44 · 2017: 36 · 2016: 36 · 2015: 54 · 2014: 36 · 2013: 44 · 2012: 61
FWCI
34.45
Type
journal article
Language
en
Open access
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • SUNY Digital Repository Support (State University of New York System) (submittedVersion, cc-by-nc-nd)
Funders
  • U.S. Environmental Protection Agency (RD832141, R827027, 82860901, RR00645)
  • V. Kann Rasmussen Foundation
  • Educational Foundation of America
  • Irving A. Hansen Memorial Foundation
  • Centers for Disease Control and Prevention
  • National Institute of Environmental Health Sciences (5 R01ES10165, R01ES012468, P01ES009600, R01ES010165, 5R01ES11158, R01ES008977, R01ES011158)
  • National Center for Research Resources (RR 00645, M01RR000645)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
chlorpyrifos, prenatal pesticide exposure, brain development, umbilical cord plasma, cognitive development, motor development, attention deficits, attention deficit hyperactivity disorder, pervasive developmental disorders, child behavior, neurotoxicants
MeSH terms
Adult, Child, Preschool, Cognition, Chlorpyrifos, Female, Humans, Infant, Insecticides, Male, Motor Skills, Nervous System, Pregnancy, Prenatal Exposure Delayed Effects, Time Factors, Urban Population

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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