The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Developmental Neurotoxicity of Pyrethroid Insecticides: Critical Review and Future Research Needs
Open accessAbstract
Pyrethroid insecticides have been used for more than 40 years and account for 25% of the worldwide insecticide market. Although their acute neurotoxicity to adults has been well characterized, information regarding the potential developmental neurotoxicity of this class of compounds is limited. There is a large age dependence to the acute toxicity of pyrethroids in which neonatal rats are at least an order of magnitude more sensitive than adults to two pyrethroids. There is no information on age-dependent toxicity for most pyrethroids. In the present review we examine the scientific data related to potential for age-dependent and developmental neurotoxicity of pyrethroids. As a basis for understanding this neurotoxicity, we discuss the heterogeneity and ontogeny of voltage-sensitive sodium channels, a primary neuronal target of pyrethroids. We also summarize 22 studies of the developmental neurotoxicity of pyrethroids and review the strengths and limitations of these studies. These studies examined numerous end points, with changes in motor activity and muscarinic acetylcholine receptor density the most common. Many of the developmental neurotoxicity studies suffer from inadequate study design, problematic statistical analyses, use of formulated products, and/or inadequate controls. These factors confound interpretation of results. To better understand the potential for developmental exposure to pyrethroids to cause neurotoxicity, additional, well-designed and well-executed developmental neurotoxicity studies are needed. These studies should employ state-of-the-science methods to promote a greater understanding of the mode of action of pyrethroids in the developing nervous system.
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Cites
Nomenclature of Voltage-Gated Sodium Channels
Goldin, A. L., Barchi, R. L., Caldwell, J. H., Hofmann, F., Howe, J. R., Hunter, J. C., Kallen, R. G., Mandel, G., Meisler, M. H., Netter, Y. B., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00116-1 · Cited by 1,481
De Novo Mutations in the Sodium-Channel Gene SCN1A Cause Severe Myoclonic Epilepsy of Infancy
Claes, L., Del-Favero, J., Ceulemans, B., Lagae, L., Van Broeckhoven, C., & De Jonghe, P. (2001) · The American Journal of Human Genetics · doi:10.1086/320609 · Cited by 1,292
Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment
Soderlund, D. M., Clark, J. M., Sheets, L. P., Mullin, L. S., Piccirillo, V. J., Sargent, D., Stevens, J. T., & Weiner, M. L. (2002) · Toxicology · doi:10.1016/s0300-483x(01)00569-8 · Cited by 1,015
The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
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Golden Age of Insecticide Research: Past, Present, or Future?
Casida, J. E., & Quistad, G. B. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.1 · Cited by 666
Principles and pitfalls in the analysis of prenatal treatment effects in multiparous species
Holson, R. R., & Pearce, B. (1992) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(92)90020-b · Cited by 503
Common Mechanism of Toxicity: A Case Study of Organophosphorus Pesticides,
Mileson, B. (1998) · Toxicological Sciences · doi:10.1006/toxs.1997.2431 · Cited by 445
A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action
Meek, M. E. (., Bucher, J. R., Cohen, S. M., Dellarco, V., Hill, R. N., Lehman-McKeeman, L. D., Longfellow, D. G., Pastoor, T., Seed, J., & Patton, D. E. (2003) · Critical Reviews in Toxicology · doi:10.1080/713608373 · Cited by 444
Neuronal Ion Channels as the Target Sites of Insecticides
Narahashi, T. (1996) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1996.tb00234.x · Cited by 440
Compact Myelin Dictates the Differential Targeting of Two Sodium Channel Isoforms in the Same Axon
Boiko, T., Rasband, M. N., Levinson, S. R., Caldwell, J. H., Mandel, G., Trimmer, J. S., & Matthews, G. (2001) · Neuron · doi:10.1016/s0896-6273(01)00265-3 · Cited by 423
Cited by
Potential developmental neurotoxicity of pesticides used in Europe
Bjørling-Poulsen, M., Andersen, H. R., & Grandjean, P. (2008) · Environmental Health · doi:10.1186/1476-069x-7-50 · Cited by 407
Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
Goines, P. E., & Ashwood, P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.006 · Cited by 314
Putative adverse outcome pathways relevant to neurotoxicity
Bal-Price, A., Crofton, K. M., Sachana, M., Shafer, T. J., Behl, M., Forsby, A., Hargreaves, A., Landesmann, B., Lein, P. J., Louisse, J., et al. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2014.981331 · Cited by 114
Self-citationToxicokinetics of lambda-cyhalothrin in rats
Anadón, A., Martínez, M., Martínez, M. A., Díaz, M. J., & Martínez-Larrañaga, M. R. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.01.014 · Cited by 86
Metadata
- Authors
- Shafer, T. J., Meyer, D. A., & Crofton, K. M.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-02
- Volume
- 113
- Issue
- 2
- Pages
- 123-136
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2069002937
- Cited by
- 538
- References
- 84
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- gold
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