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Renal and Neurologic Effects of Cadmium, Lead, Mercury, and Arsenic in Children: Evidence of Early Effects and Multiple Interactions at Environmental Exposure Levels
Open accessAbstract
Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children's health is little known. We studied their effects on two main targets, the renal and dopaminergic systems, in > 800 children during a cross-sectional European survey. Control and exposed children were recruited from those living around historical nonferrous smelters in France, the Czech Republic, and Poland. Children provided blood and urine samples for the determination of the metals and sensitive renal or neurologic biomarkers. Serum concentrations of creatinine, cystatin C, and beta2-microglobulin were negatively correlated with blood lead levels (PbB), suggesting an early renal hyperfiltration that averaged 7% in the upper quartile of PbB levels (> 55 microg/L; mean, 78.4 microg/L). The urinary excretion of retinol-binding protein, Clara cell protein, and N-acetyl-beta-d-glucosaminidase was associated mainly with cadmium levels in blood or urine and with urinary mercury. All four metals influenced the dopaminergic markers serum prolactin and urinary homovanillic acid, with complex interactions brought to light. Heavy metals polluting the environment can cause subtle effects on children's renal and dopaminergic systems without clear evidence of a threshold, which reinforces the need to control and regulate potential sources of contamination by heavy metals. Key words: arsenic, biomarkers, cadmium, dopaminergic, heavy metals, interactions, lead, mercury, renal.
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Cites
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
Cited by
Current status of cadmium as an environmental health problem
Järup, L., & Åkesson, A. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.04.020 · Cited by 2,355
Scientific Opinion on Lead in Food
(CONTAM), E. P. O. C. I. T. F. C. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1570 · Cited by 1,080
Meeker, J. D., & Stapleton, H. M. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901332 · Cited by 696
Lead-related nephrotoxicity: A review of the epidemiologic evidence
Ekong, E. B., Jaar, B. G., & Weaver, V. M. (2006) · Kidney International · doi:10.1038/sj.ki.5001809 · Cited by 366
Metadata
- Authors
- de Burbure, C., Buchet, J.-P., Leroyer, A., Nisse, C., Haguenoer, J.-M., Mutti, A., Smerhovský, Z., Cikrt, M., Trzcinka-Ochocka, M., Razniewska, G., Jakubowski, M., & Bernard, A.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-04
- Volume
- 114
- Issue
- 4
- Pages
- 584-590
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1998160973
- Cited by
- 345
- References
- 1
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- de Burbure, C., Buchet, J.-P., Leroyer, A., Nisse, C., Haguenoer, J.-M., Mutti, A., Smerhovský, Z., Cikrt, M., Trzcinka-Ochocka, M., Razniewska, G., Jakubowski, M., & Bernard, A. (2006). Renal and Neurologic Effects of Cadmium, Lead, Mercury, and Arsenic in Children: Evidence of Early Effects and Multiple Interactions at Environmental Exposure Levels. Environmental Health Perspectives. https://doi.org/10.1289/ehp.8202
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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