The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Aryl Hydrocarbon Receptor–Independent Toxicity of Weathered Crude Oil during Fish Development
Open accessAbstract
Polycyclic aromatic hydrocarbons (PAHs), derived largely from fossil fuels and their combustion, are pervasive contaminants in rivers, lakes, and nearshore marine habitats. Studies after the Exxon Valdez oil spill demonstrated that fish embryos exposed to low levels of PAHs in weathered crude oil develop a syndrome of edema and craniofacial and body axis defects. Although mechanisms leading to these defects are poorly understood, it is widely held that PAH toxicity is linked to aryl hydrocarbon receptor (AhR) binding and cytochrome P450 1A (CYP1A) induction. Using zebrafish embryos, we show that the weathered crude oil syndrome is distinct from the well-characterized AhR-dependent effects of dioxin toxicity. Blockade of AhR pathway components with antisense morpholino oligonucleotides demonstrated that the key developmental defects induced by weathered crude oil exposure are mediated by low-molecular-weight tricyclic PAHs through AhR-independent disruption of cardiovascular function and morphogenesis. These findings have multiple implications for the assessment of PAH impacts on coastal habitats.
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Cites
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899
Aryl hydrocarbon receptors: diversity and evolution
Hahn, M. E. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00070-4 · Cited by 642
Urban Sprawl Leaves Its PAH Signature
Van Metre, P. C., Mahler, B. J., & Furlong, E. T. (2000) · Environmental Science & Technology · doi:10.1021/es991007n · Cited by 466
Cited by
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish
Reid, N. M., Proestou, D. A., Clark, B. W., Warren, W. C., Colbourne, J. K., Shaw, J. R., Karchner, S. I., Hahn, M. E., Nacci, D., Oleksiak, M. F., et al. (2016) · Science · doi:10.1126/science.aah4993 · Cited by 435
Deepwater Horizon crude oil impacts the developing hearts of large predatory pelagic fish
Incardona, J. P., Gardner, L. D., Linbo, T. L., Brown, T. L., Esbaugh, A. J., Mager, E. M., Stieglitz, J. D., French, B. L., Labenia, J. S., Laetz, C. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320950111 · Cited by 422
Self-citationDevelopmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS
Shi, X., Du, Y., Lam, P. K. S., Wu, R. S. S., & Zhou, B. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.01.043 · Cited by 384
Incardona, J. P., Day, H. L., Collier, T. K., & Scholz, N. L. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.09.018 · Cited by 319
Self-citationCrude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish
Brette, F., Machado, B., Cros, C., Incardona, J. P., Scholz, N. L., & Block, B. A. (2014) · Science · doi:10.1126/science.1242747 · Cited by 310
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Metadata
- Authors
- Incardona, J. P., Carls, M. G., Teraoka, H., Sloan, C. A., Collier, T. K., & Scholz, N. L.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-12
- Volume
- 113
- Issue
- 12
- Pages
- 1755-1762
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1990131329
- Cited by
- 382
- References
- 3
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- Incardona, J. P., Carls, M. G., Teraoka, H., Sloan, C. A., Collier, T. K., & Scholz, N. L. (2005). Aryl Hydrocarbon Receptor–Independent Toxicity of Weathered Crude Oil during Fish Development. Environmental Health Perspectives. https://doi.org/10.1289/ehp.8230
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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