Cited by 245Indoor Air Quality and Microbial ExposureAsthma and respiratory diseasesOccupational exposure and asthma

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Reduction in Asthma Morbidity in Children as a Result of Home Remediation Aimed at Moisture Sources

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Kercsmar, Carolyn M., Dearborn, Dorr G., Schluchter, Mark, Xue, Lintong, Kirchner, H. Lester, Sobolewski, John, Greenberg, Stuart J., Vesper, Stephen J., Allan, Terry·2006·Environmental Health Perspectives

DOI 10.1289/ehp.8742PMC PMC1626393

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Abstract

Objective: Home dampness and the presence of mold and allergens have been associated with asthma morbidity. We examined changes in asthma morbidity in children as a result of home remediation aimed at moisture sources. Design: In this prospective, randomized controlled trial, symptomatic, asthmatic children (n = 62), 2–17 years of age, living in a home with indoor mold, received an asthma intervention including an action plan, education, and individualized problem solving. The remediation group also received household repairs, including reduction of water infiltration, removal of water-damaged building materials, and heating/ventilation/air-conditioning alterations. The control group received only home cleaning information. We measured children’s total and allergen-specific serum immuno-globulin E, peripheral blood eosinophil counts, and urinary cotinine. Environmental dust samples were analyzed for dust mite, cockroach, rodent urinary protein, endotoxin, and fungi. The follow-up period was 1 year. Results: Children in both groups showed improvement in asthma symptomatic days during the preremediation portion of the study. The remediation group had a significant decrease in symptom days (p = 0.003, as randomized; p = 0.004, intent to treat) after remodeling, whereas these parameters in the control group did not significantly change. In the postremediation period, the remediation group had a lower rate of exacerbations compared with control asthmatics (as treated: 1 of 29 vs. 11 of 33, respectively, p = 0. 003; intent to treat: 28.1% and 10.0%, respectively, p = 0.11). Conclusion: Construction remediation aimed at the root cause of moisture sources and combined with a medical/behavioral intervention significantly reduces symptom days and health care use for asthmatic children who live in homes with a documented mold problem.

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Figure 1 Unadjusted mean maximal symptom days ± 1 SE for control group and remediation group.CC0 · PubMed Central

Figure 2 Mean maximal symptom days over study duration for control and remediation groups. Values are means and 95% CIs estimated from a mixed model, adjusting for baseline asthma severity and season of the year. In the remediation group, maximal symptom days decreased significantly from baseline at 10 months (p < 0.0001) and at CV3 (p = 0.053), whereas the changes from baseline in the control group at these time points were not statistically significant. Changes from baseline at 10 months and at CV3 did not differ significantly between control and remediated groups.CC0 · PubMed Central

Figure 3 Changes from baseline to CV3 in CHSA subscales. Values are means and 95% CIs estimated from a mixed model, adjusting for baseline asthma severity and season of the year. p-Values above the x-axis, within the sections, are within-group comparisons; those below the section headings are between-group comparisons.CC0 · PubMed Central

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Authors: Kercsmar, C. M., Dearborn, D. G., Schluchter, M., Xue, L., Kirchner, H. L., Sobolewski, J., Greenberg, S. J., Vesper, S. J., & Allan, T.
Affiliations: Rainbow Babies & Children's Hospital (US)
Cuyahoga County Board of Health (US)
Environmental Health Watch, Cleveland, Ohio, USA
Environmental Protection Agency (US)
Corresponding author: Kercsmar, Carolyn M.
ORCID: Schluchter, Mark
Kirchner, H. Lester
Vesper, Stephen J.
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 2006-04-25
Volume: 114
Issue: 10
Pages: 1574-1580
ISSN: 0091-6765 (ISSN-L)
1552-9924
DOI: 10.1289/ehp.8742
PMC: PMC1626393
OpenAlex: W2064547912
Cited by: 245
References: 26
Citations by year: 2026: 6 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 14 · 2021: 12 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 15 · 2016: 14 · 2015: 17 · 2014: 12 · 2013: 15 · 2012: 17
FWCI: 8.37
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/licenses/by/4.0/ (vor, 4266 d)
Locations: Environmental Health Perspectives (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: U.S. Environmental Protection Agency
U.S. Department of Housing and Urban Development
National Institutes of Health
National Center for Research Resources (M01RR000080, M01RR00080)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords: childhood asthma, indoor mold, moisture control, dampness, asthma exacerbations, asthma action plan, specific IgE, eosinophils, urinary cotinine, house dust mites, cockroach allergens, rodent allergens, endotoxin, water infiltration
MeSH terms: Adolescent, Allergens, Asthma, Child, Child, Preschool, Dust, Housing, Humans, Humidity, Prospective Studies

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Reduction in Asthma Morbidity in Children as a Result of Home Remediation Aimed at Moisture Sources

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