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Cited by 210Environmental Toxicology and EcotoxicologyComputational Drug Discovery MethodsEnvironmental Chemistry and Analysis

The DOI matches its Crossref record; 83 of the 84 references it cites were found in a registry or an index.

Fish acute toxicity syndromes and their use in the QSAR approach to hazard assessment

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McKim, J M, Bradbury, S P, Niemi, G J·1987·Environmental Health Perspectives
DOI 10.1289/ehp.8771171PMC PMC1474360
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Abstract

Implementation of the Toxic Substances Control Act of 1977 creates the need to reliably establish testing priorities because laboratory resources are limited and the number of industrial chemicals requiring evaluation is overwhelming. The use of quantitative structure activity relationship (QSAR) models as rapid and predictive screening tools to select more potentially hazardous chemicals for in-depth laboratory evaluation has been proposed. Further implementation and refinement of quantitative structure-toxicity relationships in aquatic toxicology and hazard assessment requires the development of a "mode-of-action" database. With such a database, a qualitative structure-activity relationship can be formulated to assign the proper mode of action, and respective QSAR, to a given chemical structure. In this review, the development of fish acute toxicity syndromes (FATS), which are toxic-response sets based on various behavioral and physiological-biochemical measurements, and their projected use in the mode-of-action database are outlined. Using behavioral parameters monitored in the fathead minnow during acute toxicity testing, FATS associated with acetylcholinesterase (AChE) inhibitors and narcotics could be reliably predicted. However, compounds classified as oxidative phosphorylation uncouplers or stimulants could not be resolved. Refinement of this approach by using respiratory-cardiovascular responses in the rainbow trout, enabled FATS associated with AChE inhibitors, convulsants, narcotics, respiratory blockers, respiratory membrane irritants, and uncouplers to be correctly predicted.

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Metadata

Authors
McKim, J. M., Bradbury, S. P., & Niemi, G. J.
Affiliations
Environmental Protection Agency (US)
ORCID
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
1987-04
Volume
71
Pages
171-186
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp.8771171
PMC
PMC1474360
OpenAlex
W1975650851
Cited by
210
References
84
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 12 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 4
FWCI
2.50
Type
journal article
Language
en
Open access
Licence
public-domain
Locations
  • Environmental Health Perspectives (publishedVersion, public-domain)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
  • Physical Sciences › Environmental Science › Environmental Chemistry › Environmental Chemistry and Analysis
Keywords
QSAR, hazard assessment, fathead minnow, rainbow trout, acetylcholinesterase inhibitors, narcotics, convulsants, aquatic toxicology, compound screening, Toxic Substances Control Act
MeSH terms
Animals, Fishes, Lethal Dose 50, Structure-Activity Relationship, Water Pollutants, Water Pollutants, Chemical

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