Cited by 210Environmental Toxicology and EcotoxicologyComputational Drug Discovery MethodsEnvironmental Chemistry and Analysis

The DOI matches its Crossref record; 83 of the 84 references it cites were found in a registry or an index.

Fish acute toxicity syndromes and their use in the QSAR approach to hazard assessment

Open access

McKim, J M, Bradbury, S P, Niemi, G J·1987·Environmental Health Perspectives

DOI 10.1289/ehp.8771171PMC PMC1474360

Open this paper in CoChat — free account Open PDF

Abstract

Implementation of the Toxic Substances Control Act of 1977 creates the need to reliably establish testing priorities because laboratory resources are limited and the number of industrial chemicals requiring evaluation is overwhelming. The use of quantitative structure activity relationship (QSAR) models as rapid and predictive screening tools to select more potentially hazardous chemicals for in-depth laboratory evaluation has been proposed. Further implementation and refinement of quantitative structure-toxicity relationships in aquatic toxicology and hazard assessment requires the development of a "mode-of-action" database. With such a database, a qualitative structure-activity relationship can be formulated to assign the proper mode of action, and respective QSAR, to a given chemical structure. In this review, the development of fish acute toxicity syndromes (FATS), which are toxic-response sets based on various behavioral and physiological-biochemical measurements, and their projected use in the mode-of-action database are outlined. Using behavioral parameters monitored in the fathead minnow during acute toxicity testing, FATS associated with acetylcholinesterase (AChE) inhibitors and narcotics could be reliably predicted. However, compounds classified as oxidative phosphorylation uncouplers or stimulants could not be resolved. Refinement of this approach by using respiratory-cardiovascular responses in the rainbow trout, enabled FATS associated with AChE inhibitors, convulsants, narcotics, respiratory blockers, respiratory membrane irritants, and uncouplers to be correctly predicted.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1289/ehp.8771171

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Quantitative structure-activity relationships in fish toxicity studies Part 1: Relationship for 50 industrial pollutants
Könemann, H. (1981) · Toxicology · doi:10.1016/0300-483x(81)90130-x · Cited by 631
Structure–Toxicity Relationships for the Fathead Minnow, Pimephales promelas: Narcotic Industrial Chemicals
Veith, G. D., Call, D. J., & Brooke, L. T. (1983) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/f83-096 · Cited by 573
The use of chemical potentials as indices of toxicity
Ferguson, J. F. (1939) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1939.0030 · Cited by 559
Evaluation of Tests with Early Life Stages of Fish for Predicting Long-Term Toxicity
McKim, J. M. (1977) · Journal of the Fisheries Research Board of Canada · doi:10.1139/f77-172 · Cited by 493
Self-citation
Mechanisms of Selective Action of Pyrethroid Insecticides
Casida, J. E., Gammon, D. W., Glickman, A. H., & Lawrence, L. J. (1983) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.23.040183.002213 · Cited by 414
The Control of Respiration and Circulation in Fish During Exercise and Hypoxia
Randall, D. J. (1982) · Journal of Experimental Biology · doi:10.1242/jeb.100.1.275 · Cited by 412
Some Physical Mechanisms in Narcosis.
Mullins, L. J. (1954) · Chemical Reviews · doi:10.1021/cr60168a003 · Cited by 344
The Circulatory System
Nilsson, S. (1983) · Zoophysiology · doi:10.1007/978-3-642-81974-2_7 · Cited by 321
Effects of copper on branchial ionoregulation in the rainbow trout,Salmo gairdneri Richardson
Laurén, D. J., & McDonald, D. G. (1985) · Journal of Comparative Physiology B · doi:10.1007/bf00694455 · Cited by 293
Morphometrics of fish gills
Hughes, G. M. (1972) · Respiration Physiology · doi:10.1016/0034-5687(72)90014-x · Cited by 250

Flagged first, then by citations

Show all 84 references

1 of the 84 references couldn’t be matched to a known paper.

Sorted by citations

Classifying environmental pollutants
Verhaar, H. J. M., van Leeuwen, K., & Hermens, J. L. M. (1992) · Chemosphere · doi:10.1016/0045-6535(92)90280-5 · Cited by 801
Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval.
Hwang, D., Ramsey, J. D., & Kabanov, A. V. (2020) · Advanced drug delivery reviews · doi:10.1016/j.addr.2020.09.009 · Cited by 699
“QSPR modeling is based on the statistical analysis of the data sets and has been frequently used in the field of medicinal chemistry and chemical toxicology for the prediction of efficacy and/or toxicity of small molecules [220].”
Method
Framework for ecological risk assessment
Rodier, D. J., & Norton, S. (1992) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 598
Test No. 203: Fish, Acute Toxicity Test
OECD (2009) · OECD guidelines for the testing of chemicals. Section 2: Effects on biotic systems · doi:10.1787/9789264069961-en · Cited by 453
SWIMMING BEHAVIOR AS AN INDICATOR OF SUBLETHAL TOXICITY IN FISH
Little, E. E., & Finger, S. E. (1990) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620090103 · Cited by 413
Effects of Carbofuran, Diuron, and Nicosulfuron on Acetylcholinesterase Activity in Goldfish (Carassius auratus)
Bretaud, S., Toutant, J., & Saglio, P. (2000) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.2000.1954 · Cited by 223
Environmental Chemistry and Toxicology of Polychlorinated n-Alkanes
Tomy, G. T., Fisk, A. T., Westmore, J. B., & Muir, D. C. G. (1998) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-1-4612-1708-4_2 · Cited by 190
Rules for Distinguishing Toxicants That Cause Type I and Type II Narcosis Syndromes
Veith, G. D., & Broderius, S. J. (1990) · Environmental Health Perspectives · doi:10.1289/ehp.9087207 · Cited by 185
A SCREENING METHOD FOR RANKING AND SCORING CHEMICALS BY POTENTIAL HUMAN HEALTH AND ENVIRONMENTAL IMPACTS
Swanson, M. B., Davis, G. A., Kincaid, L. E., Schultz, T. W., Bartmess, J. E., Jones, S. L., & George, E. L. (1997) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620160237 · Cited by 173
Rainbow trout cytochrome P450s: purification, molecular aspects, metabolic activity, induction and role in environmental monitoring
Buhler, D. R., & Wang‐Buhler, J. (1998) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(98)10033-6 · Cited by 173
APPLICATION OF QSARs, EXTRAPOLATION AND EQUILIBRIUM PARTITIONING IN AQUATIC EFFECTS ASSESSMENT. I. NARCOTIC INDUSTRIAL POLLUTANTS
van Leeuwen, K., Zandt, P. T. J. V. D., Aldenberg, T., Verhaar, H. J. M., & Hermens, J. L. M. (1992) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620110216 · Cited by 170
An updated review of cold shock and cold stress in fish
Reid, C. H., Patrick, P. H., Rytwinski, T., Taylor, J. J., Willmore, W. G., Reesor, B., & Cooke, S. J. (2022) · Journal of Fish Biology · doi:10.1111/jfb.15037 · Cited by 178
Molecular Mechanisms of Crude Oil Developmental Toxicity in Fish
Incardona, J. P. (2017) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-017-0381-1 · Cited by 163
Assessment of predictive models for estimating the acute aquatic toxicity of organic chemicals
Melnikov, F., Kostal, J., Voutchkova-Kostal, A., Zimmerman, J. B., & T. Anastas, P. (2016) · Green Chemistry · doi:10.1039/c6gc00720a · Cited by 158
Crucial role of mechanisms and modes of toxic action for understanding tissue residue toxicity and internal effect concentrations of organic chemicals
Escher, B. I., Ashauer, R., Dyer, S. D., Hermens, J. L. M., Lee, J., Leslie, H. A., Mayer, P., Meador, J. P., & Warne, M. S. J. (2010) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.100 · Cited by 162
Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos
Wheelock, C. E., Eder, K. J., Werner, I., Huang, H., Jones, P. D., Brammell, B. F., Elskus, A. A., & Hammock, B. D. (2005) · Aquatic Toxicology · doi:10.1016/j.aquatox.2005.05.009 · Cited by 150
Use of category approaches, read-across and (Q)SAR: General considerations
Patlewicz, G. Y., Ball, N. S., Booth, E. D., Hulzebos, E., Zvinavashe, E., & Hennes, C. (2013) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2013.06.002 · Cited by 136
ACUTE TOXICITY OF NONPOLAR VERSUS POLAR NARCOSIS: IS THERE A DIFFERENCE?
Vaes, W. H. J., Ramos, E. U., Verhaar, H. J. M., & Hermens, J. L. M. (1998) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620170723 · Cited by 136
Predicting Modes of Toxic Action from Chemical Structure: An Overview
Bradbury, S. P. (1994) · SAR and QSAR in environmental research · doi:10.1080/10629369408028842 · Cited by 130
Self-citation
Quantitative Structure-Activity Relationships of Environmental Pollutants
Hermens, J. L. M. (1989) · The handbook of environmental chemistry · doi:10.1007/978-3-540-46161-6_3 · Cited by 130
Structure-Toxicity Relationships for Industrial Chemicals Causing Type (II) Narcosis Syndrome
Veith, G. D., & Broderius, S. J. (1987) · Springer eBooks · doi:10.1007/978-94-009-3937-0_29 · Cited by 130
Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test
Klüver, N., Vogs, C., Altenburger, R., Escher, B. I., & Scholz, S. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.08.079 · Cited by 122
Classifying environmental pollutants: Part 3. External validation of the classification system
Verhaar, H. J. M., Solbé, J. F. D. L. G., Speksnijder, J., van Leeuwen, K., & Hermens, J. L. M. (2000) · Chemosphere · doi:10.1016/s0045-6535(99)00317-3 · Cited by 120
Quantitative structure-activity relationships and ecological risk assessment: an overview of predictive aquatic toxicology research
Bradbury, S. P. (1995) · Toxicology Letters · doi:10.1016/0378-4274(95)03374-t · Cited by 118
Self-citation
Baseline Toxicity (Narcosis) of Organic Chemicals Determined by In Vitro Membrane Potential Measurements in Energy-Transducing Membranes
Escher, B. I., Eggen, R. I. L., Schreiber, U., Schreiber, Z., Vye, E., Wisner, B., & Schwarzenbach, R. P. (2002) · Environmental Science & Technology · doi:10.1021/es015844c · Cited by 118
BEHAVIORAL TOXICITY SYNDROMES: A PROMISING TOOL FOR ASSESSING TOXICITY MECHANISMS IN JUVENILE FATHEAD MINNOWS
Drummond, R. A., & Russom, C. L. (1990) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620090106 · Cited by 116
MOAtox: A comprehensive mode of action and acute aquatic toxicity database for predictive model development
Barron, M. G., Lilavois, C. R., & Martin, T. M. (2015) · Aquatic Toxicology · doi:10.1016/j.aquatox.2015.02.001 · Cited by 111
Whole-Animal Physiological Processes for the Assessment of Stress in Fishes
Beitinger, T. L., & McCauley, R. W. (1990) · Journal of Great Lakes Research · doi:10.1016/s0380-1330(90)71445-1 · Cited by 110
Examination of the behavior and liver and thyroid histology of juvenile rainbow trout (Oncorhynchus mykiss) exposed to high dietary concentrations of C10-, C11-, C12- and C14-polychlorinated n-alkanes
Cooley, H. M., Fisk, A. T., Wiens, S. C., Tomy, G. T., Evans, R. E., & Muir, D. C. G. (2001) · Aquatic Toxicology · doi:10.1016/s0166-445x(00)00172-7 · Cited by 107
Current and Future Perspectives on the Development, Evaluation, and Application of in Silico Approaches for Predicting Toxicity
Patlewicz, G. Y., & Fitzpatrick, J. M. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00388 · Cited by 110
Cardio-respiratory function and oxidative stress biomarkers in Nile tilapia exposed to the organophosphate insecticide trichlorfon (NEGUVON®)
Thomaz, J. M., Martins, N. D., Monteiro, D. A., Rantin, F. T., & Kalinin, A. L. (2009) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2008.11.003 · Cited by 105
Classification of chemicals according to mechanism of aquatic toxicity: An evaluation of the implementation of the Verhaar scheme in Toxtree
Enoch, S. J., Hewitt, M., Cronin, M., Azam, S., & Madden, J. C. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.06.052 · Cited by 96
Behavioural toxicity of organic chemical contaminants in fish: application to ecological risk assessments (ERAs)
Robinson, P. D. (2009) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/f09-069 · Cited by 96
Variation in the sensitivity of aquatic species in relation to the classification of environmental pollutants
Vaal, M. A., der Wal, J. T. V., Hoekstra, J. A., & Hermens, J. L. M. (1997) · Chemosphere · doi:10.1016/s0045-6535(97)00167-7 · Cited by 90
Overview of data and conceptual approaches for derivation of quantitative structure-activity relationships for ecotoxicological effects of organic chemicals
Bradbury, S. P., Russom, C. L., Ankley, G. T., Schultz, T. W., & Walker, J. D. (2003) · Environmental Toxicology and Chemistry · doi:10.1897/01-234 · Cited by 89
Self-citation
The joint effect of polycyclic aromatic hydrocarbons on fish behavior
Gonçalves, R., Scholze, M., Ferreira, A. M., Martins, M., & Correia, A. D. (2008) · Environmental Research · doi:10.1016/j.envres.2008.07.008 · Cited by 87
10th Anniversary Critical Review: The tissue-residue approach for toxicity assessment: concepts, issues, application, and recommendations
Meador, J. P., McCarty, L. S., Escher, B. I., & Adams, W. J. (2008) · Journal of Environmental Monitoring · doi:10.1039/b814041n · Cited by 86
Use of respiratory-cardiovascular responses of rainbow trout (Salmo gairdneri) in identifying acute toxicity syndromes in fish: Part 3. Polar narcotics
Bradbury, S. P., Henry, T. R., Niemi, G. J., Carlson, R. W., & Snarski, V. M. (1989) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620080307 · Cited by 86
Self-citation
Thiobencarb-Induced Changes in Acetylcholinesterase Activity of the Fish Anguilla anguilla
Fernández-Vega, C., Sancho, E., Ferrando, M. D., & Andreu, E. (2002) · Pesticide Biochemistry and Physiology · doi:10.1006/pest.2001.2581 · Cited by 84
Neurological effects on startle response and escape from predation by medaka exposed to organic chemicals
Carlson, R. W., Bradbury, S. P., Drummond, R. A., & Hammermeister, D. E. (1998) · Aquatic Toxicology · doi:10.1016/s0166-445x(97)00097-0 · Cited by 83
Self-citation
Sublethal Effects of an Organophosphate Insecticide on the European Eel,Anguilla anguilla
Sancho, E., Ferrando, M. D., & Andreu, E. (1997) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1996.1488 · Cited by 82
Harvesting the promise of AOPs: An assessment and recommendations
Carusi, A., Davies, M. R., Grandis, G. D., Escher, B. I., Hodges, G., Leung, K., Whelan, M., Willett, C., & Ankley, G. T. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.02.015 · Cited by 77
Mechanisms of action for general and polar narcosis: A difference in dimension
Roberts, D. W., & Costello, J. (2003) · QSAR & Combinatorial Science · doi:10.1002/qsar.200390016 · Cited by 75
General baseline toxicity QSAR for nonpolar, polar and ionisable chemicals and their mixtures in the bioluminescence inhibition assay with Aliivibrio fischeri
Escher, B. I., Baumer, A., Bittermann, K., Henneberger, L., König, M., Kühnert, C., & Klüver, N. (2017) · Environmental Science Processes & Impacts · doi:10.1039/c6em00692b · Cited by 73
A strategy for ranking environmentally occurring chemicals
Jönsson, J., Eriksson, L., Sjöstróm, M., Wold, S., & Tosato, M. L. (1989) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/0169-7439(89)80013-9 · Cited by 73
Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish
Stinckens, E., Vergauwen, L., Blackwell, B. R., Ankley, G. T., Villeneuve, D. L., & Knapen, D. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b07204 · Cited by 68
Trends in structure–toxicity relationships for carbonyl-containing α,β-unsaturated compounds
Schultz, T. W., & Yarbrough, J. W. (2004) · SAR and QSAR in environmental research · doi:10.1080/10629360410001665839 · Cited by 64
Defining the Molecular and Cellular Basis of Toxicity Using Comparative Models
Ballatori, N., & Villalobos, A. R. A. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2002.9488 · Cited by 62
Intelligent Testing Strategies
van Leeuwen, C. J., Patlewicz, G. Y., & Worth, A. P. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6102-8_11 · Cited by 62
The use of the ionization constant (pKa) in selecting models of toxicity in phenols
Schultz, T. W. (1987) · Ecotoxicology and Environmental Safety · doi:10.1016/0147-6513(87)90060-1 · Cited by 61
Response and Recovery of Brain Acetylcholinesterase Activity in the European Eel,Anguilla anguilla,Exposed to Fenitrothion
Sancho, E., Ferrando, M. D., & Andreu, E. (1997) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1997.1579 · Cited by 58
A high throughput passive dosing format for the Fish Embryo Acute Toxicity test
Vergauwen, L., Schmidt, S. N., Stinckens, E., Maho, W., Blust, R., Mayer, P., Covaci, A., & Knapen, D. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.05.041 · Cited by 57
(Q)SARs to predict environmental toxicities: current status and future needs
Cronin, M. (2017) · Environmental Science Processes & Impacts · doi:10.1039/c6em00687f · Cited by 55
Comparing the Potency of Chemicals with Multiple Modes of Action in Aquatic Toxicology: Acute Toxicity Due to Narcosis versus Reactive Toxicity of Acrylic Compounds
Freidig, A. P., Verhaar, H. J. M., & Hermens, J. L. M. (1999) · Environmental Science & Technology · doi:10.1021/es990251b · Cited by 54
JPlogP: an improved logP predictor trained using predicted data
Plante, J. P., & Werner, S. (2018) · Journal of Cheminformatics · doi:10.1186/s13321-018-0316-5 · Cited by 53
QSAR modeling of cumulative environmental end-points for the prioritization of hazardous chemicals
Gramatica, P., Papa, E., & Sangion, A. (2017) · Environmental Science Processes & Impacts · doi:10.1039/c7em00519a · Cited by 52
Interspecies quantitative structure-activity relationship model for aldehydes: Aquatic toxicity
Dimitrov, S. D., Koleva, Y. K., Schultz, T. W., Walker, J. D., & Mekenyan, O. G. (2004) · Environmental Toxicology and Chemistry · doi:10.1897/02-579 · Cited by 52
Comparison of the behavioural effects of pharmaceuticals and pesticides on Diamesa zernyi larvae (Chironomidae)
Villa, S., Nica, V. D., Pescatore, T., Bellamoli, F., Miari, F., Finizio, A., & Lencioni, V. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.03.029 · Cited by 51
Structure-toxicity relationships for nonpolar narcotics: A comparison of data from the tetrahymena, photobacterium and pimephales systems
Schultz, T. W., Wyatt, N. L., & Lin, D. T. S. (1990) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf01702363 · Cited by 51
Quantitative structure-toxicity relationships and volume fraction analyses for selected esters
Jaworska, J. S., Hunter, R. S., & Schultz, T. W. (1995) · Archives of Environmental Contamination and Toxicology · doi:10.1007/bf00213091 · Cited by 50
Profenofos toxicity to the eastern rainbow fish (Melanotaenia duboulayi)
Kumar, A., & Chapman, J. C. (1998) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620170920 · Cited by 50
Mechanism-based comparisons of acute toxicities elicited by industrial organic chemicals in procaryotic and eucaryotic systems
Jaworska, J. S., & Schultz, T. W. (1994) · Ecotoxicology and Environmental Safety · doi:10.1016/0147-6513(94)90020-5 · Cited by 50
Effects of Harmful Algal Blooms on Fish: Insights from Prymnesium parvum
Svendsen, M. B. S., Andersen, N. R., Hansen, P. J., & Steffensen, J. F. (2018) · Fishes · doi:10.3390/fishes3010011 · Cited by 49
Comparison of Tetrahymena and Pimephales Toxicity Based on Mechanism of Action
Bearden, A. P., & Schultz, T. W. (1998) · SAR and QSAR in environmental research · doi:10.1080/10629369808039153 · Cited by 49
Investigation of the Verhaar scheme for predicting acute aquatic toxicity: Improving predictions obtained from Toxtree ver. 2.6
Ellison, C. M., Madden, J. C., Cronin, M., & Enoch, S. J. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.06.009 · Cited by 48
Aquatic Toxicology: Past, Present, and Prospects
Pritchard, J. B. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93100249 · Cited by 48
QSAR for baseline toxicity and classification of specific modes of action of ionizable organic chemicals in the zebrafish embryo toxicity test
Klüver, N., Bittermann, K., & Escher, B. I. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.12.003 · Cited by 49
Predicting modes of toxic action from chemical structure
Russom, C. L., Bradbury, S. P., Broderius, S. J., Hammermeister, D. E., Drummond, R. A., & Veith, G. D. (2013) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2249 · Cited by 46
Self-citation
Evaluation of the toxicity and quantitative structure - activity Relationships (QSAR) of chlorophenols to the copepodid stage of a marine copepod (Tisbe battagliai) and two species of benthic flatfish, the flounder (Platichthys flesus) and sole (Solea solea)
Smith, S., Furay, V. J., Layiwola, P. J., & Menezes‐Filho, J. A. (1994) · Chemosphere · doi:10.1016/0045-6535(94)90234-8 · Cited by 45
Adverse Outcome Pathway (AOP) Informed Modeling of Aquatic Toxicology: QSARs, Read-Across, and Interspecies Verification of Modes of Action
Ellison, C. M., Piechota, P., Madden, J. C., Enoch, S. J., & Cronin, M. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b05918 · Cited by 45
Nonpolar Narcosis: A Review of the Mechanism of Action for Baseline Aquatic Toxicity
Schultz, T. (1989) · doi:10.1520/stp16776s · Cited by 43
Identifying the mechanism of aquatic toxicity of selected compounds by hydrophobicity and electrophilicity descriptors
Ren, S., & Schultz, T. W. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(01)00550-1 · Cited by 43
Structure-toxicity relationships for selected weak acid respiratory uncouplers
Cajina-Quezada, M., & Schultz, T. W. (1990) · Aquatic Toxicology · doi:10.1016/0166-445x(90)90066-x · Cited by 43
ESTIMATING TOTAL BODY RESIDUES AND BASELINE TOXICITY OF COMPLEX ORGANIC MIXTURES IN EFFLUENTS AND SURFACE WATERS
van Loon, W. M. G. M., Verwoerd, M. E., Wijnker, F. G., van Leeuwen, C. J., van Duyn, P., van deGuchte, C., & Hermens, J. L. M. (1997) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620160704 · Cited by 43
Interspecies sensitivity in the aquatic toxicity of aromatic amines
Ramos, E. U., Vaal, M. A., & Hermens, J. L. M. (2002) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(02)00004-2 · Cited by 42
Quantitative Relationships of Structure-Activity and Volume Fraction For Selected Nonpolar and Polar Narcotic Chemicals
Jaworska, J., & Schultz, T. W. (1993) · SAR and QSAR in environmental research · doi:10.1080/10629369308028812 · Cited by 41
Quantitative structure-activity relationships for weak acid respiratory uncouplers to Vibrio fisheri
Schultz, T. W., & Cronin, M. (1997) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620160235 · Cited by 41
QUALIFICATION OF SPONTANEOUS UNDIRECTED LOCOMOTOR BEHAVIOR OF FISH FOR SUBLETHAL TOXICITY TESTING. PART I. VARIABILITY OF MEASUREMENT PARAMETERS UNDER GENERAL TEST CONDITIONS
Vogl, C., Grillitsch, B., Wytek, R., Spieser, O. H., & Scholz, W. (1999) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620181213 · Cited by 40
Environmental RNA as a Noninvasive Tool for Assessing Toxic Effects in Fish: A Proof-of-concept Study Using Japanese Medaka Exposed to Pyrene
Hiki, K., Yamagishi, T., & Yamamoto, H. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c03737 · Cited by 38
Environmental Pollution and the Fish Heart
Incardona, J. P., & Scholz, N. L. (2017) · Fish physiology · doi:10.1016/bs.fp.2017.09.006 · Cited by 43
Structure–activity relationships for abiotic thiol reactivity and aquatic toxicity of halo-substituted carbonyl compounds
Schultz, T. W., Ralston, K. E., Roberts, D. W., Veith, G. D., & Aptula, A. O. (2007) · SAR and QSAR in environmental research · doi:10.1080/10629360601033424 · Cited by 38
QSARs for monosubstituted anilines eliciting the polar narcosis mechanism of action
Schultz, T. W., Lin, D. T. S., & Arnold, L. M. (1991) · The Science of The Total Environment · doi:10.1016/0048-9697(91)90210-6 · Cited by 38
Development of thresholds of excess toxicity for environmental species and their application to identification of modes of acute toxic action
Li, J. J., Zhang, X. J., Yang, Y., Huang, T., Li, C., Su, L., Zhao, Y. H., & Cronin, M. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.10.308 · Cited by 37
Application of QSARs in Risk Management of Existing Chemicals
Verhaar, H. J. M., van Leeuwen, K., Bol, J., & Hermens, J. L. M. (1994) · SAR and QSAR in environmental research · doi:10.1080/10629369408028839 · Cited by 37
CHEMICAL STRESS AND METABOLIC RATE IN AQUATIC INVERTEBRATES: THRESHOLD, DOSE–RESPONSE RELATIONSHIPS, AND MODE OF TOXIC ACTION
Penttinen, O., & Kukkonen, J. V. K. (1998) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620170516 · Cited by 37
Toxicological assessment of biotransformation products of pentachlorophenol: Tetrahymena population growth impairment
Bryant, S. E., & Schultz, T. W. (1994) · Archives of Environmental Contamination and Toxicology · doi:10.1007/bf00203555 · Cited by 36
Adverse Outcome Pathways: A Way of Linking Chemical Structure to In Vivo Toxicological Hazards
Schultz, T. W. (2010) · Royal Society of Chemistry eBooks · doi:10.1039/9781849732093-00346 · Cited by 35
Proteomic analysis of a model fish species exposed to individual pesticides and a binary mixture
Biales, A. D., Bencic, D. C., Flick, R. L., Blocksom, K. A., Lazorchak, J. M., & Lattier, D. L. (2010) · Aquatic Toxicology · doi:10.1016/j.aquatox.2010.09.019 · Cited by 35
Relationships of quantitative structure—Activity for normal aliphatic alcohols
Schultz, T. W., Arnold, L. M., Wilke, T. S., & Moulton, M. P. (1990) · Ecotoxicology and Environmental Safety · doi:10.1016/0147-6513(90)90026-2 · Cited by 35
Evaluation of Bioanalytical Assays for Toxicity Assessment and Mode of Toxic Action Classification of Reactive Chemicals
Harder, A., Escher, B. I., Landini, P., Tobler, N. B., & Schwarzenbach, R. P. (2003) · Environmental Science & Technology · doi:10.1021/es034197h · Cited by 34
Use of respiratory-cardiovascular responses of rainbow trout (Oncorhynchus mykiss) in identifying acute toxicity syndromes in fish: Part 4. Central nervous system seizure agents
Bradbury, S. P., Carlson, R. W., Niemi, G. J., & Henry, T. R. (1991) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620100113 · Cited by 34
Self-citation
In vivo inhibition of AChE activity in the European eel Anguilla anguilla exposed to technical grade fenitrothion
Sancho, E., Ferrando, M. D., & Andreu, E. (1998) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(98)10067-1 · Cited by 33
Factors Influencing Predictive Models for Toxicology
Benfenati, E., Piclin, N., Roncaglioni, A., & Varı̀, M. R. (2001) · SAR and QSAR in environmental research · doi:10.1080/10629360108039836 · Cited by 33
Structure-activity relationships for Di and Tri alkyl and/or halogen substituted phenols
Schultz, T. W., Wesley, S. K., & Baker, L. L. (1989) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf01701747 · Cited by 33
MULTIPLE COMPUTER-AUTOMATED STRUCTURE EVALUATION PROGRAM STUDY OF AQUATIC TOXICITY 1: GUPPY
Klopman, G., Saiakhov, R., Rosenkranz, H. S., & Hermens, J. L. M. (1999) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620181116 · Cited by 32
Similarity of anthropogenic stressors is multifaceted and scale dependent
Orr, J. A., Rillig, M. C., & Jackson, M. C. (2021) · Natural Sciences · doi:10.1002/ntls.20210076 · Cited by 31
The Acute Toxicity of Selected Alkylphenols to Young and AdultDaphnia magna
Gerritsen, A. A. M., van der Hoeven, N., & Pielaat, A. (1998) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1997.1578 · Cited by 31
Polar Narcosis in Aquatic Organisms
Bradbury, S., Carlson, R. W., & Henry, T. J. (1989) · doi:10.1520/stp16767s · Cited by 31
Self-citation
A strategy for ranking environmentally occurring chemicals
Eriksson, L., Jönsson, J., Sjöstróm, M., & Wold, S. (1989) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/0169-7439(89)80117-0 · Cited by 31
Toxicity of diuron in HepG2 cells and zebrafish embryos
Kao, C. M., Ou, W.-J., Lin, H.-D., Eva, A. W., Wang, T.-L., & Chen, S. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.01.036 · Cited by 29

Authors: McKim, J. M., Bradbury, S. P., & Niemi, G. J.
Affiliations: Environmental Protection Agency (US)
ORCID: Bradbury, S P
Niemi, G J
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 1987-04
Volume: 71
Pages: 171-186
ISSN: 0091-6765 (ISSN-L)
1552-9924
DOI: 10.1289/ehp.8771171
PMC: PMC1474360
OpenAlex: W1975650851
Cited by: 210
References: 84
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 12 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 4
FWCI: 2.50
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
Locations: Environmental Health Perspectives (publishedVersion, public-domain)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
Physical Sciences › Environmental Science › Environmental Chemistry › Environmental Chemistry and Analysis
Keywords: QSAR, hazard assessment, fathead minnow, rainbow trout, acetylcholinesterase inhibitors, narcotics, convulsants, aquatic toxicology, compound screening, Toxic Substances Control Act
MeSH terms: Animals, Fishes, Lethal Dose 50, Structure-Activity Relationship, Water Pollutants, Water Pollutants, Chemical

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fish acute toxicity syndromes and their use in the QSAR approach to hazard assessment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks