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Cited by 532

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Increased Mortality from Lung Cancer and Bronchiectasis in Young Adultsafter Exposure to Arsenic in Utero and in Early Childhood

Open access
Smith, Allan H., Marshall, Guillermo, Yuan, Yan, Ferreccio, Catterina, Liaw, Jane, von Ehrenstein, Ondine, Steinmaus, Craig, Bates, Michael N., Selvin, Steve·2006·Environmental Health Perspectives
DOI 10.1289/ehp.8832
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Abstract

Arsenic in drinking water is an established cause of lung cancer, and preliminary evidence suggests that ingested arsenic may also cause nonmalignant lung disease. Antofagasta is the second largest city in Chile and had a distinct period of very high arsenic exposure that began in 1958 and lasted until 1971, when an arsenic removal plant was installed. This unique exposure scenario provides a rare opportunity to investigate the long-term mortality impact of early-life arsenic exposure. In this study, we compared mortality rates in Antofagasta in the period 1989-2000 with those of the rest of Chile, focusing on subjects who were born during or just before the peak exposure period and who were 30-49 years of age at the time of death. For the birth cohort born just before the high-exposure period (1950-1957) and exposed in early childhood, the standardized mortality ratio (SMR) for lung cancer was 7.0 [95% confidence interval (CI), 5.4-8.9; p<0.001] and the SMR for bronchiectasis was 12.4 (95% CI, 3.3-31.7; p<0.001). For those born during the high-exposure period (1958-1970) with probable exposure in utero and early childhood, the corresponding SMRs were 6.1 (95% CI, 3.5-9.9; p<0.001) for lung cancer and 46.2 (95% CI, 21.1-87.7; p<0.001) for bronchiectasis. These findings suggest that exposure to arsenic in drinking water during early childhood or in utero has pronounced pulmonary effects, greatly increasing subsequent mortality in young adults from both malignant and nonmalignant lung disease.

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Metadata

Authors
Smith, A. H., Marshall, G., Yuan, Y., Ferreccio, C., Liaw, J., von Ehrenstein, O., Steinmaus, C., Bates, M. N., & Selvin, S.
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
2006-08
Volume
114
Issue
8
Pages
1293-1296
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp.8832
OpenAlex
W2009317934
Cited by
532
References
35
FWCI
22.66
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Increased Mortality from Lung Cancer and Bronchiectasis in Young Adultsafter Exposure to Arsenic in Utero and in Early Childhood. https://app.cochat.ai/papers/10.1289/ehp.8832
The paper
Smith, A. H., Marshall, G., Yuan, Y., Ferreccio, C., Liaw, J., von Ehrenstein, O., Steinmaus, C., Bates, M. N., & Selvin, S. (2006). Increased Mortality from Lung Cancer and Bronchiectasis in Young Adultsafter Exposure to Arsenic in Utero and in Early Childhood. Environmental Health Perspectives. https://doi.org/10.1289/ehp.8832

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.