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Estrogenicity of resin-based composites and sealants used in dentistry.
Open accessAbstract
We tested some resin-based composites used in dentistry for their estrogenic activity. A sealant based on bisphenol-A diglycidylether methacrylate (bis-GMA) increased cell yields, progesterone receptor expression, and pS2 secretion in human estrogen-target, serum-sensitive MCF7 breast cancer cells. Estrogenicity was due to bisphenol-A and bisphenol-A dimethacrylate, monomers found in the base paste of the dental sealant and identified by mass spectrometry. Samples of saliva from 18 subjects treated with 50 mg of a bis-GMA-based sealant applied on their molars were collected 1 hr before and after treatment. Bisphenol-A (range 90-931 micrograms) was identified only in saliva collected during a 1-hr period after treatment. The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.
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Citations
Cited by
Hahladakis, J. N., Velis, C. A., Weber, R., Iacovidou, E., & Purnell, P. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2017.10.014 · Cited by 3,873
An updated review of environmental estrogen and androgen mimics and antagonists
Sonnenschein, C., & Soto, A. M. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00027-2 · Cited by 990
Self-citationParent bisphenol A accumulation in the human maternal-fetal-placental unit.
Schönfelder, G., Wittfoht, W., Hopp, H., Talsness, C. E., Paul, M., & Chahoud, I. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.021100703 · Cited by 668
Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol
Gould, J. C., Leonard, L. S., Maness, S. C., Wagner, B. L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D. P., & Gaido, K. W. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00084-7 · Cited by 510
Perinatal Exposure to Bisphenol A Alters Early Adipogenesis in the Rat
Somm, E., Schwitzgebel, V. M., Toulotte, A., Cederroth, C. R., Combescure, C., Nef, S., Aubert, M. L., & Hüppi, P. S. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.11342 · Cited by 467
Metadata
- Authors
- Olea, N., Pulgar, R., Pérez, P., Olea-Serrano, F., Rivas, A., Novillo-Fertrell, A., Pedraza, V, Soto, A. M., & Sonnenschein, C.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-03
- Volume
- 104
- Issue
- 3
- Pages
- 298-305
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W4254311071
- Cited by
- 1,041
- References
- 0
- FWCI
- 30.28
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Estrogenicity of resin-based composites and sealants used in dentistry. https://app.cochat.ai/papers/10.1289/ehp.96104298
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- Olea, N., Pulgar, R., Pérez, P., Olea-Serrano, F., Rivas, A., Novillo-Fertrell, A., Pedraza, V, Soto, A. M., & Sonnenschein, C. (1996). Estrogenicity of resin-based composites and sealants used in dentistry. Environmental Health Perspectives. https://doi.org/10.1289/ehp.96104298
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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