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Cited by 218Methemoglobinemia and Tumor Lysis SyndromeWater Treatment and DisinfectionPublic Health and Environmental Issues

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Infantile methemoglobinemia: Reexamining the role of drinking water nitrates

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Avery, A A·1999·Environmental Health Perspectives
DOI 10.1289/ehp.99107583
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Abstract

Ingestion of nitrates in drinking water has long been thought to be a primary cause of acquired infantile methemoglobinemia, often called blue baby syndrome. However, recent research and a review of historical cases offer a more complex picture of the causes of infantile methemoglobinemia. Gastrointestinal infection and inflammation and the ensuing overproduction of nitric oxide may be the cause of many cases of infantile methemoglobinemia previously attributed to drinking water nitrates. If so, current limits on allowable levels of nitrates in drinking water, which are based solely on the health threat of infantile methemoglobinemia, may be unnecessarily strict.

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  1. [36]36. National Research Council Subcommittee on Nitrate and Nitrite in Drinking Water. Nitrate and Nitrite in Drinking Water. Washington, DC:National Academy Press, 1995.

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Metadata

Authors
Avery, A. A.
Affiliations
Hudson Institute (US)
Corresponding author
Avery, A A
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
1999-07
Volume
107
Issue
7
Pages
583-586
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp.99107583
OpenAlex
W2015001323
Cited by
218
References
34
Citations by year
2026: 3 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 21 · 2021: 2 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 6 · 2015: 18 · 2014: 13 · 2013: 17 · 2012: 6
FWCI
5.76
Type
journal article
Language
en
Open access
Licence
public-domain
Locations
  • Environmental Health Perspectives (publishedVersion, public-domain)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Methemoglobinemia and Tumor Lysis Syndrome
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Public Health and Environmental Issues
Keywords
blue baby syndrome, drinking water nitrate, nitric oxide, gastrointestinal infections, nitrate ingestion
MeSH terms
Diarrhea, Infantile, Humans, Infant, Infant, Newborn, Methemoglobinemia, Nitrates, Water Pollutants, Chemical, Water Supply

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