Endometriosis allergic or autoimmune disease: pathogenetic aspects - a case control study
Open accessAbstract
PURPOSE OF INVESTIGATION: The aim of this study was to evaluate the correlation between endometriosis and pathologies on an immune basis for the possible involvement of the immune system in the pathogenesis of endometriosis. MATERIALS AND METHODS: In this retrospective study, data of 304 patients with endometriosis and 318 without endometriosis were collected in a uniform manner for both groups and inserted into two databases, respectively, for patients with and without endometriosis. The authors calculated the percentages of patients with allergies, autoimmune diseases, asthma in both groups, and later statistical analysis were performed with two different chi-square tests. RESULTS: The results obtained have shown that patients with endometriosis have a higher prevalence of allergies (p = 0.0003) and coexistence of both allergies and autoimmune diseases (p = 0.0274), compared to those without. CONCLUSIONS: The present study seems to support the possible association between endometriosis and allergic diseases.
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Women with endometriosis are more likely to be diagnosed with inflammatory bowel diseases, allergic manifestations, and autoimmune diseases.
“An increased risk of inflammatory bowel diseases (Chron’s disease, ulcerative colitis) [146] allergic manifestations [sinus allergic rhinitis, and food allergy) [147], autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, Sjogren’s syndrome, multiple sclerosis, fibromyalgia) are more likely to be diagnosed in women with endometriosis”
From Hormonal treatments for endometriosis: The endocrine background (2022) · cites this paper as [148]
The Results and Table 1 (page unavailable in our copy) show more allergies among women with endometriosis than controls. They do not show more autoimmune disease alone: 6.25% of the endometriosis group had autoimmune disease versus 6.92% of controls, a nonsignificant difference. The paper does not report an increased risk of inflammatory bowel disease or the specific diagnoses listed in the citing sentence. (LLM, conf=0.90)
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- Authors
- Caserta, D., Mallozzi, M., Pulcinelli, F. M., Mossa, B., & Moscarini, M.
- Affiliations
- Azienda Ospedaliera Sant'Andrea (IT)
- Corresponding author
- Caserta, D.
- Venue
- Clinical and Experimental Obstetrics & Gynecology
- Publisher
- IMR Press
- Published
- 2016-06-10
- Volume
- 43
- Issue
- 3
- Pages
- 354-357
- ISSN
- 0390-6663 (ISSN-L)
- OpenAlex
- W2475330636
- Cited by
- 23
- References
- 15
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical and Experimental Obstetrics & Gynecology (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometriosis, allergy, autoimmune disease, asthma, immune system, endometriosis pathogenesis, comorbidities
- MeSH terms
- Adult, Antigen-Presenting Cells, Asthma, Autoimmune Diseases, Endometriosis, Female, Humans, Hypersensitivity, Immunity, Cellular, Italy, Middle Aged, Retrospective Studies, Tumor Necrosis Factor-alpha, Comorbidity, Prevalence, Chi-Square Distribution, Case-Control Studies, Interleukin-10, Th1 Cells, Th2 Cells, Interleukin-12, Young Adult, Immunity, Humoral
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