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Cited by 317

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Slower Decline of Glomerular Filtration Rate in the Japanese General Population: A Longitudinal 10-Year Follow-Up Study

Open access
IMAI, Enyu, HORIO, Masaru, YAMAGATA, Kunihiro, ISEKI, Kunitoshi, HARA, Shigeko, URA, Nobuyuki, KIYOHARA, Yutaka, MAKINO, Hirofumi, HISHIDA, Akira, MATSUO, Seiichi·2008·Hypertension Research

Abstract

The prevalence of stage 3 to 5 chronic kidney disease (CKD) in Japan (18.7%) is considerably higher than that in the United States (4.5%). This study investigated in the Japanese general population whether this higher prevalence of CKD might reflect to a progressive decline of renal function, and in turn to the increased risk of end-stage renal disease. A decline in renal function over 10 years was examined in 120,727 individuals aged 40 years or older who participated in the annual health examination program of the two periods over 10 years, 1988-1993 and 1998-2003. Renal function was assessed with estimated glomerular filtration rate (GFR) using the abbreviated Modification of Diet in Renal Disease (MDRD) Study equation modified by a Japanese coefficient. The rate of GFR decline in the participants was 0.36 mL/min/1.73 m2/year on average. In the male population aged 50-79, the mean rate of GFR decline was significantly higher in the presence of hypertension than in its absence. The rate of GFR decline was more than two times higher in participants with proteinuria than in those without proteinuria in both sexes. The rate was significantly higher in participants with an initial GFR<50 mL/min/1.73 m2 among the groups younger than age 70 and in participants with an initial GFR<40 mL/min/1.73 m2 in the group with age 70-79. Based on the slow rate of GFR decline, we concluded that the decline in renal function progresses slowly in the Japanese general population. Hypertension, proteinuria and lower GFR were found to be significant risk factors for a faster decline of GFR.

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Metadata

Authors
IMAI, E., HORIO, M., YAMAGATA, K., ISEKI, K., HARA, S., URA, N., KIYOHARA, Y., MAKINO, H., HISHIDA, A., & MATSUO, S.
Venue
Hypertension Research
Published
2008
Volume
31
Issue
3
Pages
433-441
ISSN
  • 0916-9636 (ISSN-L)
  • 1348-4214
OpenAlex
W2055793289
Cited by
317
References
23
FWCI
12.24
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Slower Decline of Glomerular Filtration Rate in the Japanese General Population: A Longitudinal 10-Year Follow-Up Study. https://app.cochat.ai/papers/10.1291/hypres.31.433
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IMAI, E., HORIO, M., YAMAGATA, K., ISEKI, K., HARA, S., URA, N., KIYOHARA, Y., MAKINO, H., HISHIDA, A., & MATSUO, S. (2008). Slower Decline of Glomerular Filtration Rate in the Japanese General Population: A Longitudinal 10-Year Follow-Up Study. Hypertension Research. https://doi.org/10.1291/hypres.31.433

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