Longitudinal Studies on the Rate of Decline in Renal Function with Age
Abstract
Serial creatinine clearances (5 to 14 studies) were obtained for 446 normal volunteers in the Baltimore Longitudinal Study of Aging followed between 1958 and 1981. When those subjects with possible renal or urinary tract disease and subjects on diuretics and antihypertensives were removed from the study, leaving a group of 254 "normal" subjects, the mean decrease in creatinine clearance was 0.75 ml/min/year. The slopes of the creatinine clearance vs. time fell into a normal (Gaussian) distribution around this mean. One third of all subjects followed had no absolute decrease in renal function (positive slope of creatinine clearance vs. time) and there was a small group of patients who showed a statistically significant increase (P less than 0.05) in creatinine clearance with age.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reduced thirst and reduced urine concentration by the kidney increase dehydration risk in older adults.
“Among age-related physiological changes, reduced thirst and reduced urine concentration by the kidney increase dehydration risk (9,(243)(244)(245)(246).”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [245]
Cited by
Sorted by citations
Levey, A. S., Coresh, J., Balk, E., Kausz, A. T., Levin, A., Steffes, M. W., Hogg, R. J., Perrone, R. D., Lau, J., & Eknoyan, G. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-2-200307150-00013 · Cited by 4,615 · see citing works
Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study
Hurria, A., Togawa, K., Mohile, S. G., Owusu, C., Klepin, H. D., Gross, C. P., Lichtman, S. M., Gajra, A., Bhatia, S., Katheria, V., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.34.7625 · Cited by 1,841 · see citing works
Validation of a prediction tool for chemotherapy toxicity in older adults with cancer
Hurria, A., Mohile, S., Gajra, A., Klepin, H., Muss, H., Chapman, A., Feng, T., Smith, D., Sun, C.-L., De Glas, N., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.65.4327 · Cited by 598 · see citing works
Aging, adiposity, and calorie restriction
Fontana, L. (2007) · JAMA · doi:10.1001/jama.297.9.986 · Cited by 526 · see citing works
ESPEN practical guideline: Clinical nutrition and hydration in geriatrics
Volkert, D., Beck, A. M., Cederholm, T., Cruz-Jentoft, A., Hooper, L., Kiesswetter, E., Maggio, M., Raynaud-Simon, A., Sieber, C., Sobotka, L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.01.024 · Cited by 516 · see citing works
Renal Aging: Causes and Consequences
O’Sullivan, E. D., Hughes, J., & Ferenbach, D. A. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015121308 · Cited by 484 · see citing works
Melk, A., Schmidt, B. M. W., Takeuchi, O., Sawitzki, B., Rayner, D. C., & Halloran, P. F. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00438.x · Cited by 362 · see citing works
Cellular senescence in renal ageing and disease
Sturmlechner, I., Durik, M., Sieben, C. J., Baker, D. J., & van Deursen, J. M. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.183 · Cited by 345 · see citing works
Water-loss dehydration and aging
Hooper, L., Bunn, D., Jimoh, F. O., & Fairweather-Tait, S. J. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.11.009 · Cited by 283 · see citing works
The clinical implications of ageing for rational drug therapy
Shi, S., Mörike, K., & Klotz, U. (2008) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0422-1 · Cited by 244 · see citing works
. Prediction, progression and outcomes of chronic kidney disease in older adults.
Anderson, S., Halter, J. B., Hazzard, W. R., Himmelfarb, J., Horne, F. M., Kaysen, G. A., Kusek, J. W., Nayfield, S. G., Schmader, K., Tian, Y., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008080860 · Cited by 218 · see citing works
Telomere Shortening in Kidneys with Age
MELK, A., RAMASSAR, V., HELMS, L. M. H., MOORE, R., RAYNER, D., SOLEZ, K., & HALLORAN, P. F. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v113444 · Cited by 189 · see citing works
The aging kidney: increased susceptibility to nephrotoxicity
Wang, X., Bonventre, J., & Parrish, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150915358 · Cited by 132 · see citing works
Ruggenenti, P., Abbate, M., Ruggiero, B., Rota, S., Trillini, M., Aparicio, C., Parvanova, A., Petrov Iliev, I., Pisanu, G., Perna, A., et al. (2017) · Diabetes · doi:10.2337/db16-0607 · Cited by 95 · see citing works
Use of a Urine Color Chart to Monitor Hydration Status in Nursing Home Residents
Mentes, J. C., Wakefield, B., & Culp, K. (2006) · Biological Research For Nursing · doi:10.1177/1099800405281607 · Cited by 94 · see citing works
Dussol, B., Iovanna, C., Raccah, D., Darmon, P., Morange, S., Vague, P., Vialettes, B., Oliver, C., Loundoun, A., & Berland, Y. (2005) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2005.07.003 · Cited by 84 · see citing works
Masoro, E. J. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.s1.s218 · Cited by 81 · see citing works
Grubbs, V., Lin, F., Vittinghoff, E., Shlipak, M. G., Peralta, C. A., Bansal, N., Jacobs, D. R., Siscovick, D. S., Lewis, C. E., & Bibbins-Domingo, K. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2013.10.055 · Cited by 79 · see citing works
Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age
Roeder, S. S., Stefanska, A., Eng, D. G., Kaverina, N., Sunseri, M. W., McNicholas, B. A., Rabinovitch, P., Engel, F. B., Daniel, C., Amann, K., et al. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00144.2015 · Cited by 62 · see citing works
Marra, M. V., Simmons, S. F., Shotwell, M. S., Hudson, A., Hollingsworth, E. K., Long, E., Kuertz, B., & Silver, H. J. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2015.12.011 · Cited by 54 · see citing works
Inflammation and Trajectory of Renal Function in Community‐Dwelling Older Adults
Salimi, S., Shardell, M. D., Seliger, S. L., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15268 · Cited by 48 · see citing works
Age and the thyrotropin response to hypothyroxinemia
Over, R., Mannan, S., Nsouli-Maktabi, H., Burman, K. D., & Jonklaas, J. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0281 · Cited by 45 · see citing works
Age-Related Changes in Biomarkers: Longitudinal Data from a Population-Based Sample
Glei, D. A., Goldman, N., Lin, Y.-H., & Weinstein, M. (2011) · Research on Aging · doi:10.1177/0164027511399105 · Cited by 37 · see citing works
- Authors
- Lindeman, R. D., Tobin, J., & Shock, N. W.
- Affiliations
- Georgetown University (US)
- Johns Hopkins University (US)
- Johns Hopkins Bayview Medical Center (US)
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 1985-04
- Volume
- 33
- Issue
- 4
- Pages
- 278-285
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2007789292
- Cited by
- 1,578
- References
- 0
- Citations by year
- 2026: 25 · 2025: 35 · 2024: 53 · 2023: 38 · 2022: 43 · 2021: 40 · 2020: 62 · 2019: 63 · 2018: 63 · 2017: 59 · 2016: 60 · 2015: 71 · 2014: 73 · 2013: 66 · 2012: 76
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- renal function decline, aging, creatinine clearance, longitudinal decline, normal volunteers, Baltimore Longitudinal Study of Aging
- MeSH terms
- Adult, Aged, Aging, Creatinine, Humans, Hypertension, Kidney, Longitudinal Studies, Male, Middle Aged, Regression Analysis, Urologic Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
