Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)
Open accessAbstract
A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revealed multifocal pyogranulomatous necrotic nodular lesions with numerous whitish-green fungal hyphae in the left air sac. Aspergillus flavus was isolated from the left air sac lesion. Antifungal susceptibility tests indicated that the isolate showed low susceptibility to amphotericin B (AMB), fluconazole (FLZ), VRZ and MCF.
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In the case of Okinawa rail, the authors described the environmental source of the causative agent.
“In the case of Okinawa rail, the authors described the environmental source of the causative agent [36].”
From Nationwide Survey about the Occurrence of Aspergillosis in Captive Penguins in Zoos and Aquariums in Japan (2023) · cites this paper as [36]
The paper describes soil and dead leaves in the rail’s enclosure as a possible source of Aspergillus infection. It also states that the authors found no evidence of the route of infection in this case, so it does not establish the environmental source of the causative agent. (LLM, conf=0.88)
Experimental — accuracy not yet measuredA mass outbreak of aspergillosis in kākāpō and one case in Okinawa rail were reported.
“Recently, a mass outbreak of aspergillosis in kākāpō (Strigops habroptilus) and one case in Okinawa rail (Hypotaenidia okinawae) were reported [34,36].”
From Nationwide Survey about the Occurrence of Aspergillosis in Captive Penguins in Zoos and Aquariums in Japan (2023) · cites this paper as [36]
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Research works printed but not linked: 9
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Cited by
Sorted by citations
Itoh, M., Matsumoto, N., Hagino, K., Sawayama, N., Kuwayama, M., Yamada, K., & Toyotome, T. (2023) · Animals · doi:10.3390/ani13121913 · Cited by 5 · see citing works
- Authors
- KANO, R., TSUNOI, M., NAKAYA, Y., NAGAMINE, T., & ONO, K.
- Affiliations
- Nihon University (JP)
- Okinawa Wildlife Federation, 308 Maehara, Uruma, Okinawa 904-2235, Japan
- Ministry of the Environment (JP)
- Corresponding author
- KANO, Rui
- Venue
- Journal of Veterinary Medical Science
- Published
- 2021
- Volume
- 83
- Issue
- 1
- Pages
- 28-30
- ISSN
- 0916-7250 (ISSN-L)
- 1347-7439
- PMC
- PMC7870398
- OpenAlex
- W3104214945
- Cited by
- 6
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2
- FWCI
- 0.07
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Veterinary Medical Science (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Veterinary › Small Animals › Infectious Diseases and Mycology
- Keywords
- Aspergillus flavus, avian aspergillosis, antifungal resistance, captive birds, respiratory distress, air sac lesions, amphotericin B, voriconazole, micafungin, itraconazole, fluconazole
- MeSH terms
- Animals, Antifungal Agents, Aspergillus flavus, Birds, Pharmaceutical Preparations, Female, Microbial Sensitivity Tests, Itraconazole
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