Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin
Open accessAbstract
Oxidative stress is well known as a key factor of chemical carcinogenesis. However, the actual role of oxidative stress in carcinogenesis, such as oxidative stress-related in vivo mutagenicity, remains unclear. It has been reported that 8-hydroxydeoxyguanosine (8-OHdG), an oxidized DNA lesion, might contribute to chemical carcinogenesis. Potassium bromate (KBrO3) and nitrofurantoin (NFT) are known as renal carcinogens in rats. Our previous studies showed an increase in mutant frequencies accompanied by an increased level of 8-OHdG in the kidneys of rodents following KBrO3 or NFT exposure. Furthermore, KBrO3 and NFT induced different types of gene mutations. Thus, in the present study, we performed reporter gene mutation assays and 8-OHdG measurements following KBrO3 or NFT exposure using Nrf2-proficient and Nrf2-deficient mice to clarify the relationship between KBrO3- or NFT-induced oxidative stress and subsequent genotoxicity. Administration of 1,500 ppm of KBrO3 in drinking water resulted in an increase in deletion mutations accompanied by an increase in 8-OHdG level, and administration of 2,500 ppm of NFT in diet induced an increase in guanine base substitution mutations without elevation of the 8-OHdG level in Nrf2-deficient mice. These results demonstrated that the formation of 8-OHdG, which resulted from the oxidizing potential of KBrO3, was directly involved in the increase in deletion mutations, although factors related to oxidative stress other than 8-OHdG might be crucial for NFT-induced guanine base substitution mutations. The present study provides new insight into oxidative stress-related in vivo mutagenicity.
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NOXs are disturbed in diabetic nephropathy, ischemia, kidney tumors, hypoxia, and other conditions.
“NOXs have been found to be disturbed in diabetic nephropathy, ischemia, kidney tumors, hypoxia, and other conditions (Tsuchiya et al. 2018).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Tsuchiya et al. 2018
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Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works
Primary mutagenicity screening of food additives currently used in Japan
Ishidate, M., Sofuni, T., Yoshikawa, K., Hayashi, M., Nohmi, T., Sawada, M., & Matsuoka, A. (1984) · Food and Chemical Toxicology · doi:10.1016/0278-6915(84)90271-0 · Cited by 817 · see citing works
The role of oxidative stress in chemical carcinogenesis.
Klaunig, J. E., Xu, Y., Isenberg, J. S., Bachowski, S., Kolaja, K. L., Jiang, J., Stevenson, D. E., & Walborg, E. F. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106s1289 · Cited by 515 · see citing works
Nrf2 as a novel molecular target for chemoprevention
Lee, J., & Surh, Y. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.09.042 · Cited by 514 · see citing works
Regulation of genes encoding NAD(P)H:quinone oxidoreductases
Jaiswal, A. K. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00306-3 · Cited by 428 · see citing works
Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen.
Kurokawa, Y., Maekawa, A., Takahashi, M., & Hayashi, Y. (1990) · Environmental Health Perspectives · doi:10.1289/ehp.9087309 · Cited by 412 · see citing works
Correlation between Oxidative Stress, Nutrition, and Cancer Initiation
Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G., Dayem, A. A., & Cho, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071544 · Cited by 399 · see citing works
Kasai, H., Nishimura, S., Kurokawa, Y., & Hayashi, Y. (1987) · Carcinogenesis · doi:10.1093/carcin/8.12.1959 · Cited by 344 · see citing works
Urinary biomarkers of oxidative status
Il’yasova, D., Scarbrough, P. M., & Spasojević, I. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.06.012 · Cited by 252 · see citing works
Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals
Hayashi, M., Kishi, M., Sofuni, T., & Ishidate, M. (1988) · Food and Chemical Toxicology · doi:10.1016/0278-6915(88)90001-4 · Cited by 222 · see citing works
MutM, a protein that prevents G C→T A transversions, is formamidopyrimidine-DNA glycosylase
Michaels, M. L., Pham, L., Cruz, C., & Miller, J. H. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.13.3629 · Cited by 213 · see citing works
Recent advances in the protocols of transgenic mouse mutation assays
Nohmi, T., Suzuki, T., & Masumura, K. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00077-4 · Cited by 208 · see citing works
Nakabeppu, Y. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150712543 · Cited by 206 · see citing works
Minno, A. D., Turnu, L., Porro, B., Squellerio, I., Cavalca, V., Tremoli, E., & Minno, M. N. D. D. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6508 · Cited by 200 · see citing works
Bioactivation and Hepatotoxicity of Nitroaromatic Drugs
Boelsterli, U. A., Ho, H. K., Zhou, S.-F., & Leow, K. Y. (2006) · Current Drug Metabolism · doi:10.2174/138920006778520606 · Cited by 186 · see citing works
Molecular Mechanisms of Mouse Skin Tumor Promotion
Rundhaug, J. E., & Fischer, S. M. (2010) · Cancers · doi:10.3390/cancers2020436 · Cited by 136 · see citing works
Oxidative DNA damage induced by potassium bromate under cell-free conditions and in mammalian cells
Ballmaier, D., & Epe, B. (1995) · Carcinogenesis · doi:10.1093/carcin/16.2.335 · Cited by 133 · see citing works
Nohmi, T., Kim, S.-R., & Yamada, M. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.03.033 · Cited by 89 · see citing works
Umemura, T., Kuroiwa, Y., Kitamura, Y., Ishii, Y., Kanki, K., Kodama, Y., Itoh, K., Yamamoto, M. P., Nishikawa, A., & Hirose, M. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj076 · Cited by 81 · see citing works
Self-citationMurata, M., 番匠, ユ., Inoue, S., Ito, K., Ohnishi, S., Midorikawa, K., & Kawanishi, S. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000209q · Cited by 80 · see citing works
Ishidate, M., & Yoshikawa, K. (1980) · Archives of toxicology. Supplement · doi:10.1007/978-3-642-67729-8_8 · Cited by 76 · see citing works
Kitamura, Y., Umemura, T., Kanki, K., Kodama, Y., Kitamoto, S., Saito, K., Itoh, K., Yamamoto, M. P., Masegi, T., Nishikawa, A., et al. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00352.x · Cited by 70 · see citing works
Self-citationUmemura, T. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg053 · Cited by 62 · see citing works
Self-citationChung, M. C., Bosquesi, P. L., & dos Santos, J. L. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798194512 · Cited by 60 · see citing works
Umemura, T., Kanki, K., Kuroiwa, Y., et al. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00248.x · Cited by 56 · see citing works
Self-citationUmemura, T., Kitamura, Y., Kanki, K., et al. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03221.x · Cited by 55 · see citing works
Self-citationLi, N., & Zhan, X. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00690 · Cited by 50 · see citing works
Luan, Y., Suzuki, T., Palanisamy, R., et al. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.02.029 · Cited by 39 · see citing works
Effects of Nrf2 silencing on oxidative stress‐associated intestinal carcinogenesis in mice
Yokoo, Y., Kijima, A., Ishii, Y., Takasu, S., Tsuchiya, T., & Umemura, T. (2016) · Cancer Medicine · doi:10.1002/cam4.672 · Cited by 33 · see citing works
Self-citationOkazaki, K., Ishii, Y., Kitamura, Y., Maruyama, S., Umemura, T., Miyauchi, M., Yamagishi, M., Imazawa, T., Nishikawa, A., Yoshimura, Y., et al. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00162.x · Cited by 32 · see citing works
Self-citationA Possible Role of Nrf2 in Prevention of Renal Oxidative Damage by Ferric Nitrilotriacetate
Kanki, K., Umemura, T., Kitamura, Y., Ishii, Y., Kuroiwa, Y., Kodama, Y., Itoh, K., Yamamoto, M. P., Nishikawa, A., & Hirose, M. (2008) · Toxicologic Pathology · doi:10.1177/0192623307311401 · Cited by 29 · see citing works
Self-citationBartel, L. C., de Mecca, M. M., & Castro, J. A. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.09.069 · Cited by 27 · see citing works
A possible role for cell proliferation in potassium bromate (KBrO3) carcinogenesis
Umemura, T., Sai, K., Takagi, A., et al. (1993) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01215926 · Cited by 23 · see citing works
Self-citationTasaki, M., Kuroiwa, Y., Inoue, T., Hibi, D., Matsushita, K., Kijima, A., Maruyama, S., Nishikawa, A., & Umemura, T. (2013) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2013.07.003 · Cited by 21 · see citing works
Self-citationKijima, A., Ishii, Y., Takasu, S., et al. (2015) · Toxicology · doi:10.1016/j.tox.2015.03.003 · Cited by 18 · see citing works
Self-citationUmemura, T., Kodama, Y., Kurokawa, Y., et al. (2000) · Archives of Toxicology · doi:10.1007/s002040050652 · Cited by 17 · see citing works
Self-citationOxidative DNA Damage and Mammary Cell Proliferation by Alcohol-Derived Salsolinol
Murata, M., Midorikawa, K., & Kawanishi, S. (2013) · Chemical Research in Toxicology · doi:10.1021/tx400182n · Cited by 8 · see citing works
Matsushita, K., Ishii, Y., Takasu, S., et al. (2014) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2014.09.006 · Cited by 7 · see citing works
Self-citationFormation of 8-Hydroxydeoxyguanosine in DNA and Carcinogenesis
Kasai, H., Chung, M., Kiyosawa, H., et al. (1991) · Springer eBooks · doi:10.1007/978-1-4615-3850-9_22 · Cited by 7 · see citing works
Tsuchiya, T., Kijima, A., Ishii, Y., et al. (2018) · Journal of Toxicologic Pathology · doi:10.1293/tox.2018-0014 · Cited by 5 · see citing works
Self-citation
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Research works printed but not linked: 1
- [20]IARC Working Group on the Evaluation of the Carcinogenic Risk to Humans Nitrofurantoin. IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans, Vol. 50. Lyon. 211–231. 1990.
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
- Authors
- Tsuchiya, T., Kijima, A., Ishii, Y., Takasu, S., Yokoo, Y., Nishikawa, A., Yanai, T., & Umemura, T.
- Affiliations
- National Institute of Health Sciences (JP)
- Gifu University (JP)
- Yamazaki University of Animal Health Technology (JP)
- Corresponding author
- Umemura, Takashi
- Venue
- Journal of Toxicologic Pathology
- Published
- 2018
- Volume
- 31
- Issue
- 3
- Pages
- 179-188
- ISSN
- 0914-9198 (ISSN-L)
- 1881-915X
- PMC
- PMC6077160
- OpenAlex
- W2806142935
- Cited by
- 18
- References
- 41
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Toxicologic Pathology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- oxidative stress, in vivo mutagenicity, potassium bromate, nitrofurantoin, 8-hydroxy-2'-deoxyguanosine, Nrf2, renal carcinogenesis, deletion mutations, genotoxicity, chemical carcinogenesis, Nrf2-deficient mice
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